Five new mexicanolide type limonoids from Heynea trijuga

doi:10.1007/s13659-012-0040-1

应用天然产物 ›› 2012, Vol. 2 ›› Issue (4): 145-149.DOI: 10.1007/s13659-012-0040-1

• Regular Article • 上一篇下一篇

Five new mexicanolide type limonoids from Heynea trijuga

Wei YANG^a,b, Ling-Mei KONG^a,b, Shi-Fei LI^a,b, Yan LI^a, Yu ZHANG^a, Hong-Ping HE^a, Xiao-Jiang HAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

收稿日期:2012-05-24 修回日期:2012-06-04 出版日期:2012-08-24 发布日期:2018-02-11
通讯作者: Yu ZHANG,E-mail:zhangyu@mail.kib.ac.cn;Hong-Ping HE,E-mail:hehongping@mail.kib.ac.cn
基金资助:
This work was financially supported by grants from the National Basic Research Program of China(973 Program, 2009CB522300 and 2009CB940900), National Natural Science Funding of China(31170332), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).

Five new mexicanolide type limonoids from Heynea trijuga

Wei YANG^a,b, Ling-Mei KONG^a,b, Shi-Fei LI^a,b, Yan LI^a, Yu ZHANG^a, Hong-Ping HE^a, Xiao-Jiang HAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2012-05-24 Revised:2012-06-04 Online:2012-08-24 Published:2018-02-11
Supported by:
This work was financially supported by grants from the National Basic Research Program of China(973 Program, 2009CB522300 and 2009CB940900), National Natural Science Funding of China(31170332), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province(2010CI047).

摘要/Abstract

摘要： Five new mexicanolide-type limonoids, heytrijunolides A-E(1-5) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compound 3 showed weak cytotoxicity against HL-60, SMMC-7721 and A-549 human tumor cell lines with the IC₅₀ values of 21.88, 20.66 and 12.70 μM, respectively.

关键词: Heynea trijuga, Meliaceae, limonoids, mexicanolide-type, heytrijunolide

Abstract: Five new mexicanolide-type limonoids, heytrijunolides A-E(1-5) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compound 3 showed weak cytotoxicity against HL-60, SMMC-7721 and A-549 human tumor cell lines with the IC₅₀ values of 21.88, 20.66 and 12.70 μM, respectively.

Key words: Heynea trijuga, Meliaceae, limonoids, mexicanolide-type, heytrijunolide

Wei YANG, Ling-Mei KONG, Shi-Fei LI, Yan LI, Yu ZHANG, Hong-Ping HE, Xiao-Jiang HAO. Five new mexicanolide type limonoids from Heynea trijuga[J]. 应用天然产物, 2012, 2(4): 145-149.

Wei YANG, Ling-Mei KONG, Shi-Fei LI, Yan LI, Yu ZHANG, Hong-Ping HE, Xiao-Jiang HAO. Five new mexicanolide type limonoids from Heynea trijuga[J]. Natural Products and Bioprospecting, 2012, 2(4): 145-149.

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Five new mexicanolide type limonoids from Heynea trijuga

Five new mexicanolide type limonoids from Heynea trijuga

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