Cucurbitane triterpenoids from Hemsleya penxianensis

doi:10.1007/s13659-011-0044-2

应用天然产物 ›› 2012, Vol. 2 ›› Issue (4): 138-144.DOI: 10.1007/s13659-011-0044-2

• Regular Article • 下一篇

Cucurbitane triterpenoids from Hemsleya penxianensis

Jian-Chao CHEN^a, Lin ZHOU^a, Yun-Hua WANG^b, Ren-Rong TIAN^b, Yun-Xin YAN^a, Yin NIAN^a, Yun SUN^a, Yong-Tang ZHENG^b, Ming-Hua QIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

收稿日期:2011-12-03 修回日期:2012-05-09 出版日期:2012-08-24 发布日期:2018-02-11
通讯作者: Ming-Hua QIU,E-mail:mhchiu@mail.kib.ac.cn
基金资助:
This work was financially supported by the Natural Science Foundation of Yunnan Province(2008CD158), the Western Doctoral Foundation of Chinese Academy of Sciences(J. C. Chen), the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences(P2008ZZ23, P2010ZZ14), and the Cooperative Project of Guangdong Province and CAS(2009B091300135).

Cucurbitane triterpenoids from Hemsleya penxianensis

Jian-Chao CHEN^a, Lin ZHOU^a, Yun-Hua WANG^b, Ren-Rong TIAN^b, Yun-Xin YAN^a, Yin NIAN^a, Yun SUN^a, Yong-Tang ZHENG^b, Ming-Hua QIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

Received:2011-12-03 Revised:2012-05-09 Online:2012-08-24 Published:2018-02-11
Supported by:
This work was financially supported by the Natural Science Foundation of Yunnan Province(2008CD158), the Western Doctoral Foundation of Chinese Academy of Sciences(J. C. Chen), the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences(P2008ZZ23, P2010ZZ14), and the Cooperative Project of Guangdong Province and CAS(2009B091300135).

摘要/Abstract

摘要： Two new cucurbitacins, jinfushanencins A(1) and B(2), seven new cucurbitane glycosides, jinfushanosides E-K(3-9), along with nine known analogues, were obtained from the tubers of Hemsleya penxianensis. Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Selected isolates were tested their anti-HIV-1 activities, and compound 5 showed weak anti-HIV-1 in C8166 cell(EC₅₀=5.9 μg/mL) with a selectivity index of 13.5.

关键词: cucurbitane triterpenoid, jinfushanencin, jinfushanoside, Hemsleya penxianensis

Abstract: Two new cucurbitacins, jinfushanencins A(1) and B(2), seven new cucurbitane glycosides, jinfushanosides E-K(3-9), along with nine known analogues, were obtained from the tubers of Hemsleya penxianensis. Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Selected isolates were tested their anti-HIV-1 activities, and compound 5 showed weak anti-HIV-1 in C8166 cell(EC₅₀=5.9 μg/mL) with a selectivity index of 13.5.

Key words: cucurbitane triterpenoid, jinfushanencin, jinfushanoside, Hemsleya penxianensis

Jian-Chao CHEN, Lin ZHOU, Yun-Hua WANG, Ren-Rong TIAN, Yun-Xin YAN, Yin NIAN, Yun SUN, Yong-Tang ZHENG, Ming-Hua QIU. Cucurbitane triterpenoids from Hemsleya penxianensis[J]. 应用天然产物, 2012, 2(4): 138-144.

Cucurbitane triterpenoids from Hemsleya penxianensis

Cucurbitane triterpenoids from Hemsleya penxianensis

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