Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich' in Native Americans

doi:10.1007/s13659-012-0013-4

应用天然产物 ›› 2012, Vol. 2 ›› Issue (1): 35-40.DOI: 10.1007/s13659-012-0013-4

Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich' in Native Americans

Katharina DEEG^a, Tolga EICHHORN^b, Gladys ALEXIE^c, Nadine KRETSCHMER^d, Kai ANDERSCH^e, Rudolf BAUER^d, Thomas EFFERTH^b

a Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
b Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
c Fort McPerson, Northwest Territories, Canada
d Institute of Pharmaceutical Sciences, Department Pharmacognosy, Karl-Franzens University, Graz, Austria
e Wilderness International, Dresden(Germany) and Stony Plain(Alberta, Canada

收稿日期:2012-02-12 修回日期:2012-02-16 出版日期:2012-02-24 发布日期:2018-02-11
通讯作者: Thomas EFFERTH,E-mail:efferth@uni-mainz.de

Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich' in Native Americans

Katharina DEEG^a, Tolga EICHHORN^b, Gladys ALEXIE^c, Nadine KRETSCHMER^d, Kai ANDERSCH^e, Rudolf BAUER^d, Thomas EFFERTH^b

a Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
b Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
c Fort McPerson, Northwest Territories, Canada
d Institute of Pharmaceutical Sciences, Department Pharmacognosy, Karl-Franzens University, Graz, Austria
e Wilderness International, Dresden(Germany) and Stony Plain(Alberta, Canada

Received:2012-02-12 Revised:2012-02-16 Online:2012-02-24 Published:2018-02-11

摘要/Abstract

摘要： The Gwich' in, which belong to the Athapaskan language group of Native Americans live in the borderland between Alaska and Canada. We analyzed 29 medicinal plants of this tribe for their growth inhibitory activity against CCRF-CEM T-cell acute lymphoblastic leukemia(T-ALL) cells. The anti-leukemic activity of these plants has not been investigated as yet. Considering the poor cure rates of some ALL forms, there might be a great potential for medicinal plants as resource for natural products to treat T-ALL. We found that the hexane extracts of three plants revealed considerable growth inhibition on CCRF-CEM cells. The 50% inhibition concentrations(IC₅₀) were 6.63±0.03 μg/ml for Cladina mitis, 8.65±0.38 μg/ml for Picea mariana(needles), and 9.67 ±1.36 μg/ml for Artemisia frigida. Further investigations are required to isolate the active constituents of these plants.

关键词: cytotoxicity, herbs, leukemia, medicinal plants, pharmacognosy

Abstract: The Gwich' in, which belong to the Athapaskan language group of Native Americans live in the borderland between Alaska and Canada. We analyzed 29 medicinal plants of this tribe for their growth inhibitory activity against CCRF-CEM T-cell acute lymphoblastic leukemia(T-ALL) cells. The anti-leukemic activity of these plants has not been investigated as yet. Considering the poor cure rates of some ALL forms, there might be a great potential for medicinal plants as resource for natural products to treat T-ALL. We found that the hexane extracts of three plants revealed considerable growth inhibition on CCRF-CEM cells. The 50% inhibition concentrations(IC₅₀) were 6.63±0.03 μg/ml for Cladina mitis, 8.65±0.38 μg/ml for Picea mariana(needles), and 9.67 ±1.36 μg/ml for Artemisia frigida. Further investigations are required to isolate the active constituents of these plants.

Key words: cytotoxicity, herbs, leukemia, medicinal plants, pharmacognosy

Katharina DEEG, Tolga EICHHORN, Gladys ALEXIE, Nadine KRETSCHMER, Kai ANDERSCH, Rudolf BAUER, Thomas EFFERTH. Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich' in Native Americans[J]. 应用天然产物, 2012, 2(1): 35-40.

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Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich' in Native Americans

Growth inhibition of human acute lymphoblastic CCRF-CEM leukemia cells by medicinal plants of the West-Canadian Gwich' in Native Americans

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