Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

doi:10.1007/s13659-011-0031-7

应用天然产物 ›› 2011, Vol. 1 ›› Issue (3): 116-120.DOI: 10.1007/s13659-011-0031-7

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Rui ZHAN^a,b, Xue DU^a, Jia SU^a, Xiao-Nian LI^a, Wei-Guang WANG^a, Cheng-Qin LIANG^a, Jian-Hong YANG^a, Yan LI^a, Jian-Xin PU^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

收稿日期:2011-11-17 修回日期:2011-12-07 出版日期:2011-06-24 发布日期:2018-02-11
通讯作者: Jian-Xin PU,E-mail:pujianxin@mail.kib.ac.cn;Han-Dong SUN,E-mail:hdsun@mail.kib.ac.cn
基金资助:
This work was supported financially by the NSFC-Joint Foundation of Yunnan Province(No. U0832602 to H. D. Sun), the Major State Basic Research Development Program of China(No. 2009CB522300 and 2009CB940900), the Science and Technology Program of Yunnan Province(No. 2008IF010 and 2008CD162), the NSFC(No. 81172939 to J. X. Pu), and the Major Direction Projection Foundation of CAS Intellectual Innovation Project(No. 2010KIBA05 to J. X. Pu).

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Rui ZHAN^a,b, Xue DU^a, Jia SU^a, Xiao-Nian LI^a, Wei-Guang WANG^a, Cheng-Qin LIANG^a, Jian-Hong YANG^a, Yan LI^a, Jian-Xin PU^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2011-11-17 Revised:2011-12-07 Online:2011-06-24 Published:2018-02-11
Supported by:
This work was supported financially by the NSFC-Joint Foundation of Yunnan Province(No. U0832602 to H. D. Sun), the Major State Basic Research Development Program of China(No. 2009CB522300 and 2009CB940900), the Science and Technology Program of Yunnan Province(No. 2008IF010 and 2008CD162), the NSFC(No. 81172939 to J. X. Pu), and the Major Direction Projection Foundation of CAS Intellectual Innovation Project(No. 2010KIBA05 to J. X. Pu).

摘要/Abstract

摘要： Three new ent-kauranoids, isorosthornins A-C(1-3), and a new natural product, dihydroponicidin(4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines.

关键词: Isodon rosthornii, ent-kaurane diterpenoid, cytotoxicity

Abstract: Three new ent-kauranoids, isorosthornins A-C(1-3), and a new natural product, dihydroponicidin(4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines.

Key words: Isodon rosthornii, ent-kaurane diterpenoid, cytotoxicity

Rui ZHAN, Xue DU, Jia SU, Xiao-Nian LI, Wei-Guang WANG, Cheng-Qin LIANG, Jian-Hong YANG, Yan LI, Jian-Xin PU, Han-Dong SUN. Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii[J]. 应用天然产物, 2011, 1(3): 116-120.

[1]	Pengkun Li, Qin Li, Aimin Fu, Yang Xiao, Chunmei Chen, Hucheng Zhu, Changxing Qi, Wei Wei, Yuan Zhou, Yonghui Zhang. Emestrin-type epipolythiodioxopiperazines from Aspergillus nidulans with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways[J]. 应用天然产物, 2025, 15(2): 17-17.
[2]	Dong-Yang Wang, Ming-Xing Li, Yan-Chao Xu, Peng Fu, Wei-Ming Zhu, Li-Ping Wang. Dibohemamines I-O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.[J]. 应用天然产物, 2025, 15(1): 9-9.
[3]	Yue-Mei Chen, Nan-Kai Cao, Si-Si Zhu, Meng Ding, Hai-Zhen Liang, Ming-Bo Zhao, Ke-Wu Zeng, Peng-Fei Tu, Yong Jiang. Euchrestifolines A-O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from Murraya euchrestifolia[J]. 应用天然产物, 2025, 15(1): 5-5.
[4]	Alica Fischle, Mika Lutsch, Florian Hübner, Linda Sch?ker-Hübner, Lina Schürmann, Finn K. Hansen, Svetlana A. Kalinina. Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family[J]. 应用天然产物, 2024, 14(6): 51-51.
[5]	Qi-Xiu Hai, Kun Hu, Su-Ping Chen, Yang-Yang Fu, Xiao-Nian Li, Han-Dong Sun, Hong-Ping He, Pema-Tenzin Puno. Silvaticusins A-D: ent-kaurane diterpenoids and a cyclobutane-containing ent-kaurane dimer from Isodon silvaticus[J]. 应用天然产物, 2024, 14(5): 45-45.
[6]	Shuyuan Mo, Ziming Zhao, Zi Ye, Zhihong Huang, Yaxin Zhang, Wanqi Yang, Jianping Wang, Zhengxi Hu, Yonghui Zhang. New secondary metabolites with cytotoxicity from fungus Penicillium roqueforti[J]. 应用天然产物, 2023, 13(3): 17-17.
[7]	Li Hou, Cui-Xuan Mei, Chun-Mao Yuan, Gui-Hua Tang, Duo-Zhi Chen, Qing Zhao, Hong-Ping He, Ming-Ming Cao, Xiao-Jiang Hao. Five new limonoids isolated from Walsura robusta[J]. 应用天然产物, 2023, 13(2): 7-7.
[8]	Ya-Li Hu, Xing-Ren Li, Gang Xu. Carascynol A, a hybrid of caryophyllane-type terpenoid and a C₆ unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron[J]. 应用天然产物, 2022, 12(6): 38-38.
[9]	Xin Zhang, Yun-Bao Ma, Xiao-Feng He, Tian-Ze Li, Chang-An Geng, Li-Hua Su, Shuang Tang, Zhen Gao, Ji-Jun Chen. Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha[J]. 应用天然产物, 2022, 12(3): 16-16.
[10]	Natividad Herrera Cano, Sebastian A. Andujar, Cristina Theoduloz, Daniel A. Wunderlin, Ana N. Santiago, Guillermo Schmeda-Hirschmann, Ricardo D. Enriz, Gabriela E. Feresin. Arylated analogues of cypronazole: fungicidal effect and activity on human fibroblasts. Docking analysis and molecular dynamics simulations[J]. 应用天然产物, 2022, 12(2): 9-9.
[11]	Ruo-Song Zhang, Yang-Yang Liu, Pei-Feng Zhu, Qiong Jin, Zhi Dai, Xiao-Dong Luo. Furostanol Saponins from Asparagus cochinchinensis and Their Cytotoxicity[J]. 应用天然产物, 2021, 11(6): 651-658.
[12]	Patrick O. Sakyi, Richard K. Amewu, Robert N. O. A. Devine, Emahi Ismaila, Whelton A. Miller, Samuel K. Kwofie. The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade[J]. 应用天然产物, 2021, 11(5): 489-544.
[13]	Chen Shi, Yue-Ling Peng, Juan He, Zheng-Hui Li, Ji-Kai Liu, Tao Feng. Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum[J]. 应用天然产物, 2021, 11(2): 235-241.
[14]	Yi Chen, Song-Wei Li, Fang-Zhou Yin, Min Yang, Xia-Juan Huan, Ze-Hong Miao, Xiao-Ming Wang, Yue-Wei Guo. Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus[J]. 应用天然产物, 2021, 11(1): 73-79.
[15]	Mohammad Sanad Abu-Darwish, Célia Cabral, Zulfigar Ali, Mei Wang, Shabana I. Khan, Melissa R. Jacob, Surendra K. Jain, Babu L. Tekwani, Fazila Zulfiqar, Ikhlas A. Khan, Hatem Taifour, Lígia Salgueiro, Thomas Efferth. Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities[J]. 应用天然产物, 2020, 10(5): 307-316.

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价