Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers

doi:10.1007/s13659-022-00324-5

摘要/Abstract

摘要： Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala. The biological properties such as glycosidase inhibitors, anti-virus, and anti-HIV activities, makes it interesting target for synthetical studies. This review reports different approaches and methodologies to the synthesis of alexine, and its stereoisomers as the target compounds in numerous studies.

关键词: Polyhydroxylated pyrrolizidine alkaloids, Alexine, Natural products, Alexa leiopetala

Abstract: Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala. The biological properties such as glycosidase inhibitors, anti-virus, and anti-HIV activities, makes it interesting target for synthetical studies. This review reports different approaches and methodologies to the synthesis of alexine, and its stereoisomers as the target compounds in numerous studies.

Key words: Polyhydroxylated pyrrolizidine alkaloids, Alexine, Natural products, Alexa leiopetala

Ghodsi Mohammadi Ziarani, Negar Jamasbi, Fatemeh Mohajer. Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers[J]. 应用天然产物, 2022, 12(1): 1-15.

Ghodsi Mohammadi Ziarani, Negar Jamasbi, Fatemeh Mohajer. Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers[J]. Natural Products and Bioprospecting, 2022, 12(1): 1-15.

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