The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal

doi:10.1007/s13659-020-00271-z

摘要/Abstract

摘要： Polyphenols are a large family of more than 10,000 naturally occurring compounds, which exert countless pharmacological, biological and physiological benefits for human health including several chronic diseases such as cancer, diabetes, cardiovascular, and neurological diseases. Their role in traditional medicine, such as the use of a wide range of remedial herbs (thyme, oregano, rosemary, sage, mint, basil), has been well and long known for treating common respiratory problems and cold infections. This review reports on the most highlighted polyphenolic compounds present in up to date literature and their specific antiviral perceptive properties that might enhance the body immunity facing COVID-19, and other viral infectious diseases. In fact, several studies and clinical trials increasingly proved the role of polyphenols in controlling numerous human pathogens including SARS and MERS, which are quite similar to COVID-19 through the enhancement of host immune response against viral infections by different biological mechanisms. Thus, polyphenols ought to be considered as a potential and valuable source for designing new drugs that could be used effectively in the combat against COVID-19 and other rigorous diseases.

关键词: Polyphenols, Natural product, COVID-19, SARS, Respiratory tract, Infectious diseases

Abstract: Polyphenols are a large family of more than 10,000 naturally occurring compounds, which exert countless pharmacological, biological and physiological benefits for human health including several chronic diseases such as cancer, diabetes, cardiovascular, and neurological diseases. Their role in traditional medicine, such as the use of a wide range of remedial herbs (thyme, oregano, rosemary, sage, mint, basil), has been well and long known for treating common respiratory problems and cold infections. This review reports on the most highlighted polyphenolic compounds present in up to date literature and their specific antiviral perceptive properties that might enhance the body immunity facing COVID-19, and other viral infectious diseases. In fact, several studies and clinical trials increasingly proved the role of polyphenols in controlling numerous human pathogens including SARS and MERS, which are quite similar to COVID-19 through the enhancement of host immune response against viral infections by different biological mechanisms. Thus, polyphenols ought to be considered as a potential and valuable source for designing new drugs that could be used effectively in the combat against COVID-19 and other rigorous diseases.

Key words: Polyphenols, Natural product, COVID-19, SARS, Respiratory tract, Infectious diseases

Ayman Khalil, Diana Tazeddinova. The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal[J]. 应用天然产物, 2020, 10(6): 411-429.

Ayman Khalil, Diana Tazeddinova. The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal[J]. Natural Products and Bioprospecting, 2020, 10(6): 411-429.

参考文献

1. S. Perlman, J. Netland, Nat. Rev. Microbiol. 7, 439-450 (2009)
2. D. Wu, T. Wu, Q. Liu, Z. Yang, Int. J. Infect. Dis. e94, 44-48 (2020)
3. C. Huang, Y. Wang, X. Li, Lancet 395, 497-506 (2019)
4. M.Z. Tay, C.M. Poh, L. Rénia, P.A. MacAry, L.F.P. Ng, Nat. Rev. Immunol. 20, 363-374 (2020)
5. F. Violi, D. Pastori, R. Cangemi, P. Pignatelli, L. Loffredo, Thromb Haemost. 120, 949-956 (2020)
6. T. Xu, X. Jiang, D. Denton, S. Kumar, Cell Death Differ. 27, 1-14 (2020)
7. Z. Xu, L. Shi, Y. Wang, J. Zhang, L. Huang, C. Zhang et al., Lancet Respir. Med. 8, 420-422 (2020)
8. M.L. DeDiego, J.L. Nieto-Torres, J.A. Regla-Nava et al., J. Virol. 88, 913-924 (2014)
9. T. Zhang, Y. He, W. Xu et al., Sci. China Life Sci. 63, 774-776 (2020)
10. R. Barazzoni et al., Clin. Nutr. 39(6), 1631-1638 (2020)
11. N. Zhu, D. Zhang, W. Wang, X. Li, B. Yang, J. Song et al., N. Engl. J. Med. 382, 727e33 (2020)
12. K.B. Pandey, S.I. Rizvi, Oxid. Med. Cell. Longev. 2, 270-278 (2009)
13. J. Spencer, M. Abd El Mohsen, A. Minihane, J. Mathers, Br. J. Nutr. 99, 12-22 (2008)
14. R.F.M. Silva, L. Pogačnik, Antioxidants (Basel). 9, 61 (2020)
15. J. Johari, A. Kianmehr, M.R. Mustafa, S. Abubakar, K. Zandi, Int. J. Mol. Sci. 13, 16785-16795 (2012)
16. Á. Vázquez-Calvo, N. Jiménez de Oya, M.A. Martín-Acebes, E. Garcia-Moruno, J.C. Saiz, Front. Microbiol. 8, 1314 (2017)
17. A. Roy, L. Lim, S. Srivastava, Y. Lu, J. Song, PLoS ONE 12, e0180632 (2017)
18. W. Dong et al., Sci. Rep. 4, 7237 (2014)
19. G.J. Kotwal, Vaccine 26, 3055-3058 (2008)
20. H. Rasouli, M.H. Farzaei, R. Khodarahmi, Int. J. Food Prop. 20, 1700-1741 (2017)
21. M.H. Castillo, E. Perkins, J.H. Campbell, R. Doerr, J.M. Hassett, C. Kandaswami, E. Middleton, Am. J. Sur. 158, 351-355 (1989)
22. M. Bouktaib, A. Atmani, C. Rolando Regio, Tetrahedron Lett. 43, 6263-6266 (2002)
23. B. Kinker, A.T. Comstock, U.S. Sajjan, J. Anc, Dis. Prev. Rem. 2, 111 (2014)
24. G. Williamson, C. Manach, Am. J. Clin. Nutr. 81, 243S-255S (2005)
25. Y. Li, J. Yao, C. Han et al., Nutrients 8, 167 (2016)
26. J.M. Davis, E.A. Murphy, M.D. Carmichael, Curr. Sports Med. Rep. 8, 206-213 (2009)
27. Y. Sakanashi et al., Life Sci. 83, 164-216 (2008)
28. T. Gusdinar, R. Herowati, R.E. Kartasasmita, I.K. Adnyana, JPT. 6, 182-188 (2011)
29. S. Chen, H. Jiang, X. Wu, J. Fang, Mediators Inflamm. 2016, 9340637 (2016)
30. J. Tang, P. Diao, X. Shu, L. Li, L. Xiong, Biomed. Res. Int. 2019, 7039802 (2019)
31. M.P.N. Nair, C. Kandaswami, S. Mahajan, K.C. Chadha, R. Chawda, H. Nair, N. Kumar, R.E. Nair, S.A. Schwartz, Biochim. Biophys Acta. 1593, 29-36 (2002)
32. E.A. Townsend, C.W. Sr. Emala, Am. J. Physiol. Lung Cell Mol. Physiol. 305, L396-L403 (2013)
33. L.C. Chiang, W. Chiang, M.C. Liu, C.C. Lin, J. Antimicrob. Chemother. 52, 194-198 (2003)
34. M.S. Hohmann, D.M. Habiel, A.L. Coelho, W.A. Verri, C.M. Hogaboam, Am. J. Respir. Cell Mol. Biol. 60, 28-40 (2019)
35. M. Milenković, N. Arsenović-Ranin, Z. Stojić-Vukanić, B. Bufan, D. Vučićević, I. Jančić, J. Pharm. Sci. 13, 311-319 (2010)
36. W. Wu, R. Li, X. Li et al., Viruses 8, 6 (2015)
37. K. Zandi, B. Teoh, S. Sam et al., Virol. J. 8, 560 (2011)
38. M. Farazuddin, R. Mishra, Y. Jing, V. Srivastava, A.T. Comstock, U.S. Sajjan, PLoS ONE 13, e0199612 (2018)
39. L. Chen, J. Li, C. Luo, H. Liu, W. Xu, G. Chen, Bioorg. Med. Chem. 14, 8295-8306 (2006)
40. S. Jo, H. Kim, S. Kim, D.H. Shin, M.-S. Kim, Chem. Biol. Drug Des. 94, 2023-2030 (2019)
41. S. Jo, S. Kim, D.H. Shin, M.-S. Kim, J. Enzyme Inhib. Med. Chem. 35, 145-151 (2020)
42. D. Xu, M.J. Hu, Y.Q. Wang, Y.L. Cui, Molecules 24, 1123 (2019)
43. F.Y. Fan, L.X. Sang, M. Jiang, Molecules 22, 484 (2017)
44. M. Isemura, Molecules 24, 528 (2019)
45. P. Chaterjee, S. Chandra, P. Dey et al., J. Adv. Pharm. Technol. Res. 3, 136-138 (2012)
46. B.J. Newsome, M.C. Petriello, S.G. Han et al., J. Nutr. Biochem. 25, 126-135 (2014)
47. H.R. Kim, R. Rajaiah, Q.L. Wu, S.R. Satpute, M.T. Tan, J.E. Simon, B.M. Berman, K.D. Moudgil, J. Nutr. 138, 2111-2116 (2008)
48. W.C. Reygaert, Biomed. Res. Int. 2018, 9105261 (2018)
49. D. Furushima, K. Ide, H. Yamada, Molecules 23, 1795 (2018)
50. T. Noda, T. Ojima, S. Hayasaka, C. Murata, J. Epidemiol. 22, 45-49 (2012)
51. J.X. Ling, F. Wei, N. Li et al., Acta Pharmacol. Sin. 33, 1533- 1541 (2012)
52. C. Wu, Y. Liu, Y. Yang et al., Acta Pharmacol Sin. B 10, 766-788 (2020)
53. K. Kaihatsu, M. Yamabe, Y. Ebara, Molecules 23, 2475 (2018)
54. S. Hsu, Inflamm. Allergy Drug Targets. 14, 13-18 (2015)
55. H. Hosseinzadeh, M. Nassiri-Asl, J. Endocrinol. Invest. 37, 783-788 (2014)
56. T.M. Armelle, Q. Zhao, V. Kuete, Toxicological Survey of African Medicinal Plants (Chap. 20) (Elsevier, Amsterdam, 2014), pp. 577-609
57. A. Ganeshpurkar, A.K. Saluja, Saudi Pharm. J. 25, 149-164 (2017)
58. K.W. Choy, D. Murugan, X.F. Leong, R. Abas, A. Alias, M.R. Mustafa, Front. Pharmacol. 10, 1295 (2019)
59. P. Silveira, U. Vashist, A. Cabral, K.B. Amaral, G.L. Soares, M. Dagosto, Trop. Anim. Health Prod. 41, 1319-1323 (2009)
60. J. Tao, Q. Hu, J. Yang, R. Li, X. Li, C. Lu, C. Chen, L. Wang, R. Shattock, K. Ben, Antiviral Res. 75, 227-233 (2007)
61. A.K. Ibrahim, A.I. Youssef, A.S. Arafa, S.A. Ahmed, Nat. Prod. Res. 27, 2149-2153 (2013)
62. M. Bose, M. Kamra, R. Mullick et al., Sci. Rep. 7, 3965 (2017)
63. L. Fremont, Life Sci. 66, 663-673 (2000)
64. G. Risuleo, Resveratrol (Chap. 33) (Academic Press, New York, 2016), pp. 453-464
65. F. Hajizadeh-sharafabad, A. Sahebkar, BioFactors 2019, 1-15 (2019)
66. J.K. Kundu, Y.K. Shin, S.H. Kim, Y.J. Surh, Carcinogenesis 27, 1465-1474 (2006)
67. J.M. Pezzuto, Biomol. Ther. 27, 1-14 (2019)
68. P. Mastromarino et al., Antiviral Res. 123, 15-21 (2015)
69. A.M. Varricchio et al., Ital. J. Pediatr. 40, 93 (2014)
70. N. Zang, X. Xie, Y. Deng, S. Wu, L. Wang, C. Peng, S. Li, K. Ni, Y. Luo, E. Liu, J. Virol. 85, 13061-13068 (2011)
71. S.C. Lin, C.T. Ho, W.H. Chuo et al., Effective inhibition of MERS-CoV infection by resveratrol. BMC Infect. Dis. 13(17), 144 (2017)
72. Y.Q. Li, Z.L. Li, W.J. Zhao, R.X. Wen, Q.W. Meng, Y. Zeng, Eur. J. Med. Chem. 41, 1084-1089 (2006)
73. A.Y. Chen, Y.C. Chen, Food Chem. 138, 2099-2107 (2013)
74. J.M. Calderon-Montano, E. Burgos-Moron, C. Perez-Guerrero, M.A. Lopez-Lazaro, Mini Rev. Med. Chem. 11, 298 (2011)
75. M.S. Baliga, A. Saxena, K. Kaur, F. Kalekhan, A. Chacko, P. Venkatesh, R. Fayad, Academic Press, Chapter 50. pp. 655-663 (2014)
76. J. Zhu, H. Tang, Z. Zhang, Y. Zhang, C. Qiu, L. Zhang, P. Huang, F. Li, Int. Immunopharmacol. 43, 236-242 (2017)
77. H.J. Jeong, Y.B. Ryu, S.-J. Park, J.H. Kim, H.-J. Kwon, J.H. Kim, K.H. Park, M.-C. Rho, W.S. Lee, Bioorg. Med. Chem. 17, 6816-6823 (2009)
78. R. Zhang, X. Ai, Y. Duan et al., Biomed. Pharmacother. 89, 660-672 (2017)
79. S. Schwarz, D. Sauter, K. Wang, R. Zhang, B. Sun, A. Karioti, A.R. Bilia, T. Efferth, W. Schwarz, Planta Med. 80, 177-182 (2014)
80. B. Salehi, A. Venditti, M. Sharifi-Rad et al., Int. J. Mol. Sci. 20, 1305 (2019)
81. X. Yan, M. Qi, P. Li et al., Cell Biosci. 7, 50 (2017)
82. F.R. Ali, F. Naz, S. Jyoti, Y.H. Siddique, Int. J. Food Prop. 20, 1197-1238 (2017)
83. A.L. Liu, B. Liu, H.L. Qin et al., Planta Med. 74, 847-851 (2008)
84. H. Zakaryan, E. Arabyan, A. Oo et al., Arch. Virol. 162, 2539-2551 (2017)
85. K.C. Li, Y.L. Ho, W.T. Hsieh, S.S. Huang, Y.S. Chang, G.J. Huang, Int. J. Mol. Sci. 16, 1736-1754 (2015)
86. S.F. Nabavi, N. Braidy, O. Gortzi, E. Sobarzo-Sanchez, M. Daglia, K. Skalicka-Woźniak, S.M. Nabavi, Brain Res. Bull. A 119, 1-11 (2015)
87. L. Bai, Y. Nong, Y. Shi et al., Mol. Pharm. 13, 568-577 (2015)
88. C.Y. Chen, W.H. Peng, K.D. Tsai, S.L. Hsu, Life Sci. 81, 1602-1614 (2007)
89. Y.C. Li, C.H. Yeh, M.L. Yang, Y.H. Kuan, Alternat. Med. 2012, 383608 (2012)
90. J. Lee, Y. Li, H. Chen et al., Acta Pharmacol. Sin. 31, 831-838 (2010)
91. C.C. Wu, C.Y. Fang, H.Y. Hsu, Y.J. Chen, S.P. Chou, S.Y. Huang, Y.J. Cheng, S.F. Lin, Y. Chang, C.H. Tsai, J.Y. Chen, Antiviral. Res. 132, 99-110 (2016)
92. C.-Y. Chen, W.-H. Peng, L.-C. Wu, C.-C. Wu, S.-L. Hsu, J. Agric. Food Chem. 58, 11653-11661 (2010)
93. M. Das, A. Ram, B. Ghosh, Inflamm. Res. 52, 101-106 (2003)
94. L. Yi, Z. Li, K. Yuan, X. Qu, J. Chen, G. Wang et al., J. Virol. 78, 11334-11339 (2004)
95. B.-S. Wang, L.-J. Juang, J.-J. Yang, L.-Y. Chen, H.-M. Tai, M.-H. Huang, Altern. Med. 2012, 431081 (2012)
96. K. Polkowski, A.P. Mazurek, Acta Pol. Pharm. 57, 135-155 (2000)
97. A. Andres, S.M. Donovan, M.S. Kuhlenschmidt, J. Nutr. Biochem. 20, 563-569 (2009)
98. B. Wei, S.-Y. Cha, M. Kang, Y.-J. Kim, C.-W. Cho et al., J. Ethn. Foods. 2, 47-51 (2015)
99. D. Sauter, S. Schwarz, K. Wang, R. Zhang, B. Sun, W. Schwarz, Planta Med. 80, 682-687 (2014)
100. H. Huang, D. Liao, L. Liang et al., Arch. Virol. 160, 1421-1433 (2015)
101. C. Bime, C.Y. Wei, J. Holbrook, L.J. Smith, R.A. Wise, Prim. Care Respir. J 21, 398-404 (2012)
102. E. Arabyan, A. Hakobyan, A. Kotsinyan et al., Antiviral Res. 156, 128-137 (2018)
103. A.A. Kolokoltsov, S. Adhikary, J. Garver et al., Arch. Virol. 157, 121-127 (2012)
104. B. Salehi, P.V.T. Fokou, M. Sharifi-Rad et al., Pharmaceuticals (Basel) 12, 11 (2019)
105. E. Ramos-Tovar, P. Muriel, Academic Press, Chapter 9. Pp. 101-121 (2019)
106. M. Bacanlı, A. Başaran, N. Başaran, Academic Press, Chapter 4. Pp. 37-44 (2018)
107. A.H.D. Cataneo, D. Kuczera, A.C. Koishi et al., Sci. Rep. 9, 16348 (2019)
108. S. Frabasile, A.C. Koishi, D. Kuczera et al., Sci. Rep. 7, 41864 (2017)
109. L. Pohjala, A. Utt, M. Varjak, A. Lulla, A. Merits, T. Ahola, P. Tammela, PLoS ONE 6, e28923 (2011)
110. A.A. Fouad, W.H. Albuali, I. Jresat, Pharmacology 97, 224-232 (2016)
111. D.H. Yu, C.H. Ma, Z.Q. Yue, X. Yao, C.M. Mao, Inflammation 38, 195-204 (2015)
112. N. Kahkeshani, F. Farzaei, M. Fotouhi et al., Iran J. Basic Med. Sci. 22, 225-237 (2019)
113. M. Govea-Salas, A.M. Rivas-Estilla, R. Rodríguez-Herrera et al., Exp. Ther. Med. 11, 619-624 (2016)
114. J.M. Kratz, C.R. Andrighetti-Fröhner, D.J. Kolling, P.C. Leal, C.C. Cirne-Santos, R.A. Yunes, R.J. Nunes, E. Trybala et al., Mem. Inst. Oswaldo. Cruz. 103, 437-442 (2008)
115. H.J. Choi, J.H. Song, K.S. Park, S.H. Baek, Lett. Appl. Microbiol. 50, 438-440 (2010)
116. J.H. Lee, M. Oh, J.H. Seok, S. Kim, D.B. Lee, G. Bae, K.H. Kim, Viruses 8, 157 (2016)
117. H.L. You, C.C. Huang, C.J. Chen, C.C. Chang, P.L. Liao, S.T. Huang, J. Chin Med. Assoc. 81, 458-468 (2018)
118. H.J. Choi, J.H. Song, L.R. Bhatt, S.H. Baek, Phytother. Res. 24, 1292-1296 (2010)
119. J.-R. Weng, C.-S. Lin, H.-C. Lai, Y.-P. Lin, C.-Y. Wang, Y.-C. Tsai, K.-C. Wu, S.-H. Huang, Virus Res. 273, 197767 (2019)
120. P. Pietta, M. Minoggio, L. Bramati, Studies in Natural Products Chemistry (Elsevier, Amsterdam, 2003), pp. 257-312
121. K.M.M. Espíndola, R.G. Ferreira, L.E.M. Narvaez et al., Front. Oncol. 9, 541 (2019)
122. M.F. Tolba, H.A. Omar, S.S. Azab, A.E. Khalifa, A.B. AbdelNaim, S.Z. Abdel-Rahman, Crit. Rev. Food Sci. Nutr. 56, 2183-2190 (2016)
123. M. Ogawa, Y. Shirasago, S. Ando, M. Shimojima, M. Saijo, M. Fukasawa, J. Infect. Chemother. 24, 597-601 (2018)
124. P.C. Wang, D.C. Chiu, J.T. Jan, W.I. Huang, Y.C. Tseng, T.T. Li, T.J. Cheng, K.C. Tsai, J.M. Fang, Eur. J. Med. Chem. 10, 224-234 (2018)
125. Y. Xie, B. Huang, K. Yu et al., Bioorg. Med. Chem. Lett. 23, 3556-3560 (2013)
126. J. Langland, B. Jacobs, C.E. Wagner, G. Ruiz, T.M. Cahill, Antiviral Res. 160, 143-150 (2018)
127. E.M. Aldred, C. Buck, K. Vall, Churchill Livingstone Chapter 38. pp 299-306 (2009)
128. J. Liggins, J.C.L. Bluck, S. Runswick, C. Atkinson, W.A. Coward, S.A. Bingham, J. Nutr. Biochem. 11, 326-331 (2000)
129. M. Ritchie, J. Cummings, M. Morton, C. Steel, C. Bolton-Smith, Br. J. Nutr. 95, 204-213 (2006)
130. S. Li, L. Yuan, Y. Chen, W. Zhou, X. Wang, Molecules 22, 2183 (2017)
131. R. Zhang, Y. Li, W. Wang, Nutr. Cancer. 29, 24-28 (1997)
132. G. Feng, B. Sun, T.Z. Li, Int. Immunopharmacol. 26, 392-400 (2015)
133. S. Soumyakrishnan, T. Divya, S. Kalayarasan, N. Sriram, G. Sudhandiran, Biochimie 103, 23-36 (2014)
134. Y. Horio, R. Sogabe, M. Shichiri et al., J. Clin. Biochem. Nutr. 66, 36-42 (2020)
135. S.-T. Chung, Y.-T. Huang, H.-Y. Hsiung, W.-H. Huang, C.-W. Yao, A.-R. Lee, Chem. Biodivers. 12, 685-696 (2015)
136. R. Mani, V. Natesan, Phytochemistry 145, 187-196 (2018)
137. S. Samarghandian, T. Farkhondeh, M. Azimi-Nezhad, DoseResponse. 23, 1559325817711782 (2017)
138. Q. Du, X. Gu, J. Cai, M. Huang, M. Su, Mol. Med. Rep. 6, 100-104 (2012)
139. J.W. Critchfield, S.T. Butera, T.M. Folks, A.I.D.S. Res, Hum. Retroviruses. 12, 39 (1996)
140. J. Wang, T. Zhang, J. Du, S. Cui, F. Yang, Q. Jin, PLoS ONE 9, 89668 (2014)
141. C. Wu, Y. Liu, Y. Yang et al., Acta Pharm. Sin B. 10, 766-788 (2020)
142. K. Zduńska, A. Dana, A. Kolodziejczak, H. Rotsztejn, Pharmacol. Physiol. 31, 332-336 (2018)
143. N. Kumar, V. Pruthi, Biotechnol. Rep (Amst). 4, 86-93 (2014)
144. L. Paiva, R. Goldbeck, W.D. Santos, F.M. Squina, Braz. J. Pharm. Sci. 49, 395-411 (2013)
145. X. Yuan, Y. Wang, D. Du et al., Inflammation. 35, 1161-1168 (2012)
146. Y. Zhu, Y. Shao, X. Qu, J. Guo, J. Yang, Z. Zhou, S. Wang, Biochem. Biophys. Res. Commun. 512, 793-798 (2019)
147. M. Hariono, N. Abdullah, K. Damodaran et al., Sci. Rep. 6, 38692 (2016)
148. A.A. Zanwar, S.L. Badole, P.S. Shende, M.V. Hegde, S.L. Bodhankar, Academic Press, Chapter 76. pp. 989-992 (2014)
149. S. Kara, B. Gencer, T. Karaca et al., Sci. World J. 2014, 797824 (2014)
150. M. Camps-Bossacoma, À. Franch, F.J. Pérez-Cano, M. Castell, Nutrients 9, 580 (2017)
151. H. Parhiz, A. Roohbakhsh, F. Soltani, R. Rezaee, M. Iranshahi, Phytother. Res. 29, 323-331 (2015)
152. J. Kim, M.B. Wie, M. Ahn, A. Tanaka, H. Matsuda, T. Shin, Anat. Cell Biol. 52, 369-377 (2019)
153. H.W. Meng, H.M. You, Y. Yang, Y.L. Zhang, X.M. Meng, T.T. Ma, C. Huang, J. Li, Toxicology 421, 9-21 (2019)
154. Y. Zhang, Y. Zheng, W. Shi et al., Molecules 24, 3663 (2019)
155. N. Wang, C. Geng, H. Sun, X. Wang, F. Li, X. Liu, Arch. Pharm. Res. 42, 1063-1070 (2019)
156. E. Seyedrezazadeh, S. Kolahia, A.A. Shahbazfar, K. Ansarin, P.M. Moghaddam, M. Sakhinia, E. Sakhinia, M. Vafa, Phytother Res. 29, 591-598 (2015)
157. H.W. Wang, L. Shi, Y.P. Xu, X.Y. Qin, Q.Z. Wang, Exp. Ther. Med. 14, 3713-3719 (2017)
158. H.M.R. Piva, J.M. Sá, A.S. Miranda et al., Int. J. Mol. Sci. 21, 2241 (2020)
159. C.W. Lin, F.J. Tsai, C.H. Tsai et al., Antiviral Res. 68, 36-42 (2005)
160. F. Huang, Y. Li, E.L. Leung et al., Pharmacol. Res. 158, 104929 (2020)
161. M.C. Gálvez, C.G. Barroso, J.A. Pérez-Bustamante, Z. Lebensm Unters Forch. 199, 29-31 (1994)
162. M. Gitzinger, C. Kemmer, D.A. Fluri, M.D. El-Baba, W. Weber, M. Fussenegger, Nucleic Acids Res. 40, e37 (2012)
163. S. Sethupathy, S. Ananthi, A. Selvaraj et al., Sci. Rep. 7, 16328 (2017)
164. V.P. Mahendra, D.J. Haware, R. Kumar, J. Funct. Foods. 56, 110-118 (2019)
165. L.C. Chiang, L.T. Ng, W. Chiang, M.Y. Chang, C.C. Lin, Planta Med. 69, 600-604 (2003)
166. A. Itoh, K. Isoda, M. Kondoh, M. Kawase, M. Kobayashi, M. Tamesada, K. Yagi, Biol. Pharm. Bull. 32, 1215-1219 (2009)
167. C. Calixto-Campos, T.T. Carvalho, M.S. Hohmann, F.A. PinhoRibeiro, V. Fattori et al., J. Nat. Prod. 78, 1799-1808 (2015)
168. S.J. Kim, M.C. Kim, J.Y. Um, S.H. Hong, Molecules 15, 7208 (2010)
169. Y. Sun, X. Gong, J.Y. Tan et al., Front. Pharmacol. 7, 308 (2016)
170. Y. Kong, Z. Feng, A. Chen, Q. Qi, M. Han, S. Wang, Y. Zhang, X. Zhang, N. Yang, J. Wang et al., Front. Oncol. 9, 942 (2019)
171. M. Bacanlı, A.A. Başaran, N. Başaran, Academic Press, Chapter 34. Pp. 433-438 (2018)
172. D. Fang, Z. Xiong, J.J. Xu, L.R. Yin, Biomed. Pharmacother. 109, 2054-2061 (2019)
173. M.Y. Heo, S.J. Sohn, W.W. Au, Mutat. Res. 488, 135-150 (2001)
174. X. Wang, G. Gong, W. Yang, Y. Li, M. Jiang, L. Li, Environ. Toxicol. Pharmacol. 36, 288-295 (2013)
175. Y.N. Liu, W.J. Zha, Y. Ma et al., Sci. Rep. 5, 11758 (2015)
176. W.J. Zha et al., Evid. Based Complement. Alternat. Med. 2013, 767689 (2013)
177. Y. Shu, W. Tao, Q. Miao et al., Inflammation. 37, 1661-1668 (2014)
178. L.J.K. Henry, M.K. Ramar, S. Palanisamy, S. Natesan, R. Kandasamy, Biochem. Biophys. Res. Commun. 526, 833-840 (2020)
179. J.J. Meyer, A.J. Afolayan, M.B. Taylor, D. Erasmus, J. Ethnopharmacol. 56, 165-169 (1997)
180. M. Kheiry, M. Dianat, M. Badavi, S.A. Mard, V. Bayati, Avicenna J. Phytomed. 10, 50-57 (2020)
181. H. Boz, Int. J. Food Sci. Technol. 50, 2323-2328 (2015)
182. K. Pei, J. Ou, J. Huang, S. Ou, J. Sci. Food Agric. 96, 2952-2962 (2016)
183. J.J. Chen, J.S. Deng, C.C. Huang, P.Y. Li, Y.C. Liang, C.Y. Chou, G.J. Huang, Am. J. Chin. Med. 47, 1483-1506 (2019)
184. R. Amber, M. Adnan, A. Tariq, S. Mussarat, J. Pharm. Pharmacol. 69, 109-122 (2017)
185. P. Schnitzler, A. Neuner, S. Nolkemper, Phytother. Res. 24, 20-28 (2010)
186. A.A. Elfiky, J. Biomol. Struct. Dyn. 2020, 1-10 (2020)
187. J.F. Barquero, Reprint. (2020). https://doi.org/10.1101/20200323002881
188. T. Dimitrios, O. Vassiliki, Academic Press, Chapter 16. pp. 263-284 (2019)
189. C.C.-Y. Oliver, J.B. Blumberg, Academic Press, Chapter 85. pp. 831-841 (2009)
190. J.K. Lee, Arch. Pharm. Res. 34, 671-679 (2011)
191. W.-Y. Zhang, J.-J. Lee, Y. Kim et al., J. Agric. Food Chem. 60, 7652-7658 (2012)
192. W. Li, Q. Du, X. Li et al., Front. Pharmacol 11, 114 (2016)
193. I. Mokdad-Bzeouich, N. Mustapha, A. Sassi et al., Cell Stress Chaperon. 21, 773-781 (2016)
194. G.F. Zhu, H.J. Guo, Y. Huang, C.T. Wu, X.F. Zhang, Exp. Ther. Med. 10, 2259-2266 (2015)
195. J.P. Ley, G. Krammer, G. Reinders, I.L. Gatfield, H.J. Bertram, J. Agric. Food Chem. 53, 6061-6066 (2005)
196. M.T. Ul Qamar, S.M. Alqahtani, M.A. Alamri, L.L. Chen, J. Pharm. Anal. 3, 9 (2020)
197. M. Smith, J.C. Smith, Reprint. https://doi.org/10.26434/chemrxiv11871402v4 (2020)
198. B. Arumugam, K. Balagangadharan, N. Selvamurugan, J. Cell Commun. Signal. 12, 561-573 (2018)
199. K.H. Kim, R. Tsao, R. Yang, S.W. Cui, Food Chem. 95, 466-473 (2005)
200. S. Cheemanapalli, R. Mopuri, R. Golla, C.M. Anuradha, S.K. Chitta, Biomed. Pharmacother. 108, 547-557 (2018)
201. L.A. Figueroa, L.B. Navarro, M. Patino, L.P. Vera, Int. J. Pharm. Pharm. Sci. 6, 497-502 (2014)
202. Y. Li, L. Zhang, X. Wang, W. Wu, R. Qin, Drug Dev. Res. 80, 253-261 (2019)
203. C.H. Lin, T.T. Chang, M.F. Sun, H.Y. Chen, F.J. Tsai, K.L. Chang, M. Fisher, C.Y. Chen, J. Biomol. Struct. Dyn. 28, 471-482 (2011)
204. W. Peng, R. Qin, X. Li, H. Zhou, Bot. J. Ethnopharmacol. 148, 729-745 (2013)
205. W. Liu, P. Chen, J. Deng, J. Lv, J. Liu, Ann. NY. Acad. Sci. 1403, 82-91 (2017)
206. Q.H. Du, C. Peng, H. Zhang, Pharm. Biol. 51, 1347-1354 (2013)
207. R. Li, J. Li, Y. Huang et al., Int. J Biol. Sci. 14, 1411-1425 (2018)
208. G. Ravagnan, A. De Filippis, M. Carteni, S. De Maria, M. Cozza, V. Petrazzuolo, M.A. Tufano, G. Donnarumma, Inflammation 36, 26-34 (2013)
209. S.Y. Guan, K. Zhang, X.S. Wang et al., Model Mol. Pain 16, 1744806919900717 (2020)
210. T. Li, Y. Liu, W. Xu et al., Lab. Invest. 99, 819-829 (2019)
211. J. Tang, Y. Li, J. Wang, Q. Wu, H. Yan, J. Cell Biochem. 120, 10137-10144 (2019)
212. H. Zeng, Y. Wang, Y. Gu, J. Wang, H. Zhang, H. Gao, Q. Jin, L. Zhao, Life Sci. 218, 25-30 (2019)
213. Q. Jiang, M. Yi, Q. Guo, C. Wang, H. Wang, S. Meng, C. Liu, Y. Fu, H. Ji, T. Chen, Immunopharmacology 29, 370-376 (2015)
214. X.D. Yan, Q.M. Wang, C. Tie et al., Sci. Rep. 7, 40030 (2017)
215. Q. Miao, X.P. Shi, M.X. Ye et al., Int. J. Mol. Sci. 13, 7776-7787 (2012)
216. C.J. Lin, H.J. Lin, T.H. Chen, Y.A. Hsu, C.S. Liu, G.Y. Hwang, L. Wan, PLoS ONE 10, e0117602 (2015)
217. S. Adem, V. Eyupoglu, I. Sarfraz, A. Rasul, M. Ali, Preprints 2020030333 (2020)
218. E. Szliszka, D. Skaba, Z.P. Czuba, W. Krol, Molecules 16, 3701-712 (2011)
219. L. Zhou, J. Tang, X. Yang et al., Front. Pharmacol. 10, 1589 (2020)
220. M. Shi, J. Zhang, C. Liu et al., Molecules 24, 1699 (2019)
221. D.W. Kim, K.H. Seo, M.J. Curtis-Long, K.Y. Oh, J.-W. Oh, J.K. Cho, K.H. Park, J. Enzyme Inhib. Med. Chem. 29, 59-63 (2014)
222. Y.J. Kim, W.I. Choi, H. Ko, Y. So, K.S. Kang, I. Kim, K. Kim, H.G. Yoon, T.J. Kim, K.C. Choi, Life Sci. 95, 101-107 (2014)
223. A.E. Nkengfack, T.W. Vouffo, Z.T. Fomum, M. Meyer, O. Bergendorff, O. Sterner, Phytochemistry 36, 1047-1051 (1994)
224. J.S. Mani, J.B. Johnson, J.C. Steel, D.A. Broszczak, P.M. Neilsen, K.B. Walsh, M. Naiker, Virus Res. 284, 197989 (2020)

[1]	Haoqi Dong, Xinni Yang, Peiying Wang, Weiya Huang, Liang Zhang, Song Song, Jiangxin Liu. Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A[J]. 应用天然产物, 2025, 15(3): 21-21.
[2]	Hesham R. El-Seedi, Mohamed S. Refaey, Nizar Elias, Mohamed F. El-Mallah, Faisal M. K. Albaqami, Ismail Dergaa, Ming Du, Mohamed F. Salem, Haroon Elrasheid Tahir, Maria Dagliaa, Nermeen Yosri, Hongcheng Zhang, Awg H. El-Seedi, Zhiming Guo, Shaden A. M. Khalifa. Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023)[J]. 应用天然产物, 2025, 15(2): 13-13.
[3]	Xiaoxia Gu, Xiaotian Zhang, Xueke Zhang, Xinyu Wang, Weiguang Sun, Yonghui Zhang, Zhengxi Hu. Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations[J]. 应用天然产物, 2025, 15(1): 3-3.
[4]	María I. Osella, Mario O. Salazar, Carlos M. Solís, Ricardo L. E. Furlan. New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract[J]. 应用天然产物, 2025, 15(1): 4-4.
[5]	Ahmed H. Elbanna, Xinhui Kou, Dilip V. Prajapati, Surasree Rakshit, Rebecca A. Butcher. Discovery of a parallel family of euglenatide analogs in Euglena gracilis[J]. 应用天然产物, 2025, 15(1): 10-10.
[6]	Qiantong Liu, Yanyun Liu, Tingting Liu, Jinbao Fan, Zanxian Xia, Yingjun Zhou, Xu Deng. Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments[J]. 应用天然产物, 2024, 14(6): 55-55.
[7]	Song-Yu Hou, Bing-Chao Yan, Han-Dong Sun, Pema-Tenzin Puno. Recent advances in the application of [2+2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products[J]. 应用天然产物, 2024, 14(5): 37-37.
[8]	Felaine Anne Sumang, Alan Ward, Jeff Errington, Yousef Dashti. Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2[J]. 应用天然产物, 2024, 14(5): 40-40.
[9]	Chunsong Hu. Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease[J]. 应用天然产物, 2024, 14(2): 2-2.
[10]	Shohreh Ariaeenejad, Javad Gharechahi, Mehdi Foroozandeh Shahraki, Fereshteh Fallah Atanaki, Jian-Lin Han, Xue-Zhi Ding, Falk Hildebrand, Mohammad Bahram, Kaveh Kavousi, Ghasem Hosseini Salekdeh. Precision enzyme discovery through targeted mining of metagenomic data[J]. 应用天然产物, 2024, 14(1): 7-7.
[11]	Daniel W. Armstrong, Alain Berthod. Occurrence of D-amino acids in natural products[J]. 应用天然产物, 2023, 13(6): 47-47.
[12]	Xinxin Li, Runlu Shi, Lingchen Yan, Weiwei Chu, Ruishuang Sun, Binkai Zheng, Shuai Wang, Hui Tan, Xusheng Wang, Ying Gao. Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression[J]. 应用天然产物, 2023, 13(6): 54-54.
[13]	Dalila Carbone, Carmela Gallo, Genoveffa Nuzzo, Giusi Barra, Mario Dell'Isola, Mario Affuso, Olimpia Follero, Federica Albiani, Clementina Sansone, Emiliano Manzo, Giuliana d'Ippolito, Angelo Fontana. Marine natural product lepadin A as a novel inducer of immunogenic cell death via CD91-dependent pathway[J]. 应用天然产物, 2023, 13(5): 34-34.
[14]	Phanankosi Moyo, Luke Invernizzi, Sephora M. Mianda, Wiehan Rudolph, Warren A. Andayi, Mingxun Wang, Neil R. Crouch, Vinesh J. Maharaj. Leveraging off higher plant phylogenetic insights for antiplasmodial drug discovery[J]. 应用天然产物, 2023, 13(5): 35-35.
[15]	Phanankosi Moyo, Luke Invernizzi, Sephora M. Mianda, Wiehan Rudolph, Andrew W. Andayi, Mingxun Wang, Neil R. Crouch, Vinesh J. Maharaj. Prioritised identification of structural classes of natural products from higher plants in the expedition of antimalarial drug discovery[J]. 应用天然产物, 2023, 13(5): 37-37.