Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

doi:10.1007/s13659-018-0168-8

应用天然产物 ›› 2018, Vol. 8 ›› Issue (5): 355-360.DOI: 10.1007/s13659-018-0168-8

• ORIGINAL ARTICLES • 上一篇下一篇

Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

Li Liu^1,2, Jun-Jie Han^1,2, Tian-Shun Xu³, Rui-Xing Liu^1,2, Li Bao¹, Hong-Wei Liu^1,2

1 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
2 Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 College of Life Sciences, Hebei University, Baoding 071002, China

收稿日期:2018-03-25 修回日期:2018-05-15 出版日期:2018-10-24 发布日期:2018-09-19
通讯作者: Hong-Wei Liu
基金资助:
This work was financially supported by the National Natural Science Foundation of China (21472233 and 81673334).

Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

Li Liu^1,2, Jun-Jie Han^1,2, Tian-Shun Xu³, Rui-Xing Liu^1,2, Li Bao¹, Hong-Wei Liu^1,2

1 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China;
2 Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 College of Life Sciences, Hebei University, Baoding 071002, China

Received:2018-03-25 Revised:2018-05-15 Online:2018-10-24 Published:2018-09-19
Contact: Hong-Wei Liu
Supported by:
This work was financially supported by the National Natural Science Foundation of China (21472233 and 81673334).

摘要/Abstract

摘要： Three new heptelidic acid derivatives (1-3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1-5 was postulated. Compounds 1-5 exhibited no antibacterial activity against Staphylococcus aureus and Escherichia coli at the dose of 100 μM.

关键词: Lentinellus ursinus, Heptelidic acid derivatives, Biosynthetic pathway

Abstract: Three new heptelidic acid derivatives (1-3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1-5 was postulated. Compounds 1-5 exhibited no antibacterial activity against Staphylococcus aureus and Escherichia coli at the dose of 100 μM.

Key words: Lentinellus ursinus, Heptelidic acid derivatives, Biosynthetic pathway

Li Liu, Jun-Jie Han, Tian-Shun Xu, Rui-Xing Liu, Li Bao, Hong-Wei Liu. Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus[J]. 应用天然产物, 2018, 8(5): 355-360.

Li Liu, Jun-Jie Han, Tian-Shun Xu, Rui-Xing Liu, Li Bao, Hong-Wei Liu. Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus[J]. Natural Products and Bioprospecting, 2018, 8(5): 355-360.

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Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

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