Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis

doi:10.1007/s13659-017-0121-2

应用天然产物 ›› 2017, Vol. 7 ›› Issue (2): 201-206.DOI: 10.1007/s13659-017-0121-2

• Original article • 上一篇下一篇

Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis

Li-Xia Wang, Hai-Rong Zheng, Fu-Cai Ren, Tian-Ge Chen, Xiang-Mei Li, Xian-Jun Jiang, Fei Wang

BioBioPha Co., Ltd., Kunming 650201, People's Republic of China

收稿日期:2016-12-15 修回日期:2017-01-10 出版日期:2017-04-24 发布日期:2018-02-06
通讯作者: Fei Wang,e-mail:f.wang@mail.biobiopha.com
基金资助:
This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China.

Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis

Li-Xia Wang, Hai-Rong Zheng, Fu-Cai Ren, Tian-Ge Chen, Xiang-Mei Li, Xian-Jun Jiang, Fei Wang

BioBioPha Co., Ltd., Kunming 650201, People's Republic of China

Received:2016-12-15 Revised:2017-01-10 Online:2017-04-24 Published:2018-02-06
Supported by:
This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China.

摘要/Abstract

摘要： Four hitherto unknown polysubstituted isoflavonoids, including three isoflavans:7,4'-dihydroxy-8,2',3'-trimethoxyisoflavan (1), 7,2',4'-trihydroxy-8,3'-dimethoxyisoflavan (2), and 7,2',4'-trihydroxy-5-methoxyisoflavan (3), and one prenylated isoflavone cudraisoflavone M (4) were isolated from the ethanol extracts of Spatholobus suberectus (for 1 and 2), Flemingia macrophylla (for 3), and Cudrania cochinchinensis (for 4), respectively. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1 and 4 exhibited weak cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480).

关键词: Spatholobus suberectus, Flemingia macrophylla, Cudrania cochinchinensis, Isoflavan, Isoflavone, Cytotoxicity

Abstract: Four hitherto unknown polysubstituted isoflavonoids, including three isoflavans:7,4'-dihydroxy-8,2',3'-trimethoxyisoflavan (1), 7,2',4'-trihydroxy-8,3'-dimethoxyisoflavan (2), and 7,2',4'-trihydroxy-5-methoxyisoflavan (3), and one prenylated isoflavone cudraisoflavone M (4) were isolated from the ethanol extracts of Spatholobus suberectus (for 1 and 2), Flemingia macrophylla (for 3), and Cudrania cochinchinensis (for 4), respectively. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1 and 4 exhibited weak cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480).

Key words: Spatholobus suberectus, Flemingia macrophylla, Cudrania cochinchinensis, Isoflavan, Isoflavone, Cytotoxicity

Li-Xia Wang, Hai-Rong Zheng, Fu-Cai Ren, Tian-Ge Chen, Xiang-Mei Li, Xian-Jun Jiang, Fei Wang. Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis[J]. 应用天然产物, 2017, 7(2): 201-206.

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Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis

Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis

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