Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

doi:10.1007/s13659-015-0059-1

应用天然产物 ›› 2015, Vol. 5 ›› Issue (2): 105-109.DOI: 10.1007/s13659-015-0059-1

• Original article • 上一篇

Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

Da-Song Yang¹, Shuang-Mei Wang¹, Wei-Bing Peng², Yong-Ping Yang¹, Ke-Chun Liu², Xiao-Li Li¹, Wei-Lie Xiao³

1. Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. Biology Institute of Shandong Academy of Sciences, Jinan 250014, People's Republic of China;
3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

收稿日期:2015-01-27 修回日期:2015-03-31 出版日期:2015-04-24 发布日期:2018-02-11
基金资助:
This work was financially supported by National Natural Science Foundation of China(31300293 and 81422046), General Project of Applied Foundation Research, Yunnan Province(2013FB067), Basic Research Project of Ministry of Science and Technology of China(2012FY110300), Major State Basic Research Development Program(2010CB951704).

Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

Da-Song Yang¹, Shuang-Mei Wang¹, Wei-Bing Peng², Yong-Ping Yang¹, Ke-Chun Liu², Xiao-Li Li¹, Wei-Lie Xiao³

1. Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. Biology Institute of Shandong Academy of Sciences, Jinan 250014, People's Republic of China;
3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

Received:2015-01-27 Revised:2015-03-31 Online:2015-04-24 Published:2018-02-11
Supported by:
This work was financially supported by National Natural Science Foundation of China(31300293 and 81422046), General Project of Applied Foundation Research, Yunnan Province(2013FB067), Basic Research Project of Ministry of Science and Technology of China(2012FY110300), Major State Basic Research Development Program(2010CB951704).

摘要/Abstract

摘要： Three new minor prenylated flavonoids, named macadenanthins A-C(1-3), together with three known ones(4-6), were isolated from the twigs of Macaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds 1-3 were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines(MCF-7, Hep G2, Hela and P388) and showed IC₅₀ values in the range of 13.76-22.27 μM.

关键词: Macaranga adenantha, Prenylated Flavonoids, Macadenanthins A–C, Cytotoxicity

Abstract: Three new minor prenylated flavonoids, named macadenanthins A-C(1-3), together with three known ones(4-6), were isolated from the twigs of Macaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds 1-3 were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines(MCF-7, Hep G2, Hela and P388) and showed IC₅₀ values in the range of 13.76-22.27 μM.

Key words: Macaranga adenantha, Prenylated Flavonoids, Macadenanthins A–C, Cytotoxicity

Da-Song Yang, Shuang-Mei Wang, Wei-Bing Peng, Yong-Ping Yang, Ke-Chun Liu, Xiao-Li Li, Wei-Lie Xiao. Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity[J]. 应用天然产物, 2015, 5(2): 105-109.

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Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

Minor Prenylated Flavonoids from the Twigs of Macaranga adenantha and Their Cytotoxic Activity

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