Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

doi:10.1007/s13659-014-0013-7

应用天然产物 ›› 2014, Vol. 4 ›› Issue (2): 113-118.DOI: 10.1007/s13659-014-0013-7

• Original article • 上一篇下一篇

Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

Elmar Breuer¹, Thomas Efferth²

1. Veterinary Clinic for Pets, Müllheim/Baden, Germany;
2. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

收稿日期:2014-02-25 修回日期:2014-04-01 出版日期:2014-04-24 发布日期:2018-02-11
通讯作者: Thomas Efferth,e-mail:efferth@uni-mainz.de
基金资助:
The technical assistance of Mrs. Doris Rohr and the secretarial assistance of Mrs. Ilona Zirbs are gratefully acknowledged. We are indebted to Karen Duffy(Cornell University, Ithaca, NY, USA) for critically reading the manuscript.

Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

Elmar Breuer¹, Thomas Efferth²

1. Veterinary Clinic for Pets, Müllheim/Baden, Germany;
2. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

Received:2014-02-25 Revised:2014-04-01 Online:2014-04-24 Published:2018-02-11
Supported by:
The technical assistance of Mrs. Doris Rohr and the secretarial assistance of Mrs. Ilona Zirbs are gratefully acknowledged. We are indebted to Karen Duffy(Cornell University, Ithaca, NY, USA) for critically reading the manuscript.

摘要/Abstract

摘要： Artemisinin, a constituent of Artemisia annua L. , is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo. Herbal extracts of A. annua inhibit the growth of cancer cell lines. Here, we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A. annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without tumor relapse. Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months, respectively. A. annua was well tolerated without noticeable side effects. These four cases indicate that A. annua may be a promising herbal drug for cancer therapy.

关键词: Artemisinin, Asteraceae, Scopoletin, Veterinary cancer, Comparative oncology

Abstract: Artemisinin, a constituent of Artemisia annua L. , is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo. Herbal extracts of A. annua inhibit the growth of cancer cell lines. Here, we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A. annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without tumor relapse. Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months, respectively. A. annua was well tolerated without noticeable side effects. These four cases indicate that A. annua may be a promising herbal drug for cancer therapy.

Key words: Artemisinin, Asteraceae, Scopoletin, Veterinary cancer, Comparative oncology

Elmar Breuer, Thomas Efferth. Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua[J]. 应用天然产物, 2014, 4(2): 113-118.

Elmar Breuer, Thomas Efferth. Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua[J]. Natural Products and Bioprospecting, 2014, 4(2): 113-118.

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Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua

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