整合生物学期刊网

应用天然产物 ›› 2014, Vol. 4 ›› Issue (2): 119-128.DOI: 10.1007/s13659-014-0015-5

• Original article • 上一篇    下一篇

Nine New Farnesylphenols from the Basidiomycete Albatrellus Caeruleoporus

Liang-Yan Liu1,2, Zheng-Hui Li1, Gang-Qiang Wang1, Kun Wei1, Ze-Jun Dong1, Tao Feng1, Gen-Tao Li1, Yan Li1, Ji-Kai Liu1   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
    2. University of the Chinese Academy of Sciences, Beijing 100049, China
  • 收稿日期:2014-03-16 修回日期:2014-03-16 出版日期:2014-04-24 发布日期:2018-02-11
  • 通讯作者: Ji-Kai Liu,e-mail:jkliu@mail.kib.ac.cn
  • 基金资助:
    This project was supported by the National Natural Sciences Foundation of China(U1132607).

Nine New Farnesylphenols from the Basidiomycete Albatrellus Caeruleoporus

Liang-Yan Liu1,2, Zheng-Hui Li1, Gang-Qiang Wang1, Kun Wei1, Ze-Jun Dong1, Tao Feng1, Gen-Tao Li1, Yan Li1, Ji-Kai Liu1   

  1. 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
    2. University of the Chinese Academy of Sciences, Beijing 100049, China
  • Received:2014-03-16 Revised:2014-03-16 Online:2014-04-24 Published:2018-02-11
  • Supported by:
    This project was supported by the National Natural Sciences Foundation of China(U1132607).

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摘要： Nine previously-unreported farnesylphenols, involving eight neogrifolin derivatives(1-8) and one grifolin analogue(9), together with three known compounds, were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus. Their structures were elucidated as(S)-17-hydroxy-18, 20-ene-neogrifolin(1),(S)-18, 19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10, 22-ene-neogrifolin(3),(9S, 10R)-6, 10-epoxy-9-hydroxyneo grifolin(4),(9S, 10R)-6, 9-epoxy-10-hydroxyneogrifolin(5),(-)-13, 14-dihydroxyneogrifolin(6), albatrelin G(7), albatrelin H(8), and one grifolin analogue,(S)-10-hydroxygrifolin(9), grifolin(10), neogrifolin(11), and albatrellin(12) by extensive spectroscopic analyses and chemical methods. Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.

关键词: Albatrellus caeruleoporus, Mushroom, Polyporaceae, Farnesylphenols

Abstract: Nine previously-unreported farnesylphenols, involving eight neogrifolin derivatives(1-8) and one grifolin analogue(9), together with three known compounds, were isolated from the fruiting bodies of the mushroom Albatrellus caeruleoporus. Their structures were elucidated as(S)-17-hydroxy-18, 20-ene-neogrifolin(1),(S)-18, 19-dihydroxyneogrifolin(2),(S)-9-hydroxy-10, 22-ene-neogrifolin(3),(9S, 10R)-6, 10-epoxy-9-hydroxyneo grifolin(4),(9S, 10R)-6, 9-epoxy-10-hydroxyneogrifolin(5),(-)-13, 14-dihydroxyneogrifolin(6), albatrelin G(7), albatrelin H(8), and one grifolin analogue,(S)-10-hydroxygrifolin(9), grifolin(10), neogrifolin(11), and albatrellin(12) by extensive spectroscopic analyses and chemical methods. Compounds 7 and 8 showed weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.

Key words: Albatrellus caeruleoporus, Mushroom, Polyporaceae, Farnesylphenols

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