New amide alkaloids from Piper longum fruits

doi:10.1007/s13659-013-0073-0

应用天然产物 ›› 2013, Vol. 3 ›› Issue (6): 277-281.DOI: 10.1007/s13659-013-0073-0

• Regular Article • 上一篇下一篇

New amide alkaloids from Piper longum fruits

Jun YANG^a, Yao SU^a,b, Ji-Feng LUO^a, Wei GU^a, Hong-Mei NIU^a, Yan LI^c, Yue-Hu WANG^a, Chun-Lin LONG^a,d

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b College of Resources and Environmental Sciences, Hebei Agricultural University, Hebei 071000, China;
c State Key Laboratory of Phytochemisty and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
d College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China

收稿日期:2013-09-15 修回日期:2013-11-12 出版日期:2013-12-24 发布日期:2018-02-11
通讯作者: Yue-Hu WANG,E-mail:wangyuehu@mail.kib.ac.cn;Chun-Lin LONG,E-mail:long@mail.kib.ac.cn
基金资助:
This work was funded by the Natural Science Foundation of Yunnan Province, China (No. 2011FZ205), the National Natural Science Foundation of China (Nos. 31070288, 31161140345), the Ministry of Education of China through its 111 and 985 projects (Nos. B08044, MUC98506-01000101 & MUC985-9), and the Japan Society for the Promotion of Science (No. JSPS/AP/109080).

New amide alkaloids from Piper longum fruits

Jun YANG^a, Yao SU^a,b, Ji-Feng LUO^a, Wei GU^a, Hong-Mei NIU^a, Yan LI^c, Yue-Hu WANG^a, Chun-Lin LONG^a,d

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b College of Resources and Environmental Sciences, Hebei Agricultural University, Hebei 071000, China;
c State Key Laboratory of Phytochemisty and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
d College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China

Received:2013-09-15 Revised:2013-11-12 Online:2013-12-24 Published:2018-02-11
Supported by:
This work was funded by the Natural Science Foundation of Yunnan Province, China (No. 2011FZ205), the National Natural Science Foundation of China (Nos. 31070288, 31161140345), the Ministry of Education of China through its 111 and 985 projects (Nos. B08044, MUC98506-01000101 & MUC985-9), and the Japan Society for the Promotion of Science (No. JSPS/AP/109080).

摘要/Abstract

摘要： Three new amide alkaloids piperlongumamides A-C (1-3), together with 12 known ones (4-15), were isolated from the fruits of Piper longum. The structures of the new isolates were determined using spectroscopic data analyses. Cytotoxic activity of these amides against HL-60 (human leukemia), A-549 (human lung cancer), MCF-7 (human breast cancer), SMMC-7721 (human liver cancer) and SW480 (human rectal cancer) cell lines were evaluated. Piperchabamide B (11) exhibited weak inhibitory activity against HL-60 (IC₅₀=21.32 μM), A-549 (IC₅₀=23.82 μM) and MCF-7 (IC₅₀=16.58 μM) cell lines.

关键词: Piperaceae, Piper longum, amide alkaloids, piperlongumamides, piperchabamide B, cytotoxicity

Abstract: Three new amide alkaloids piperlongumamides A-C (1-3), together with 12 known ones (4-15), were isolated from the fruits of Piper longum. The structures of the new isolates were determined using spectroscopic data analyses. Cytotoxic activity of these amides against HL-60 (human leukemia), A-549 (human lung cancer), MCF-7 (human breast cancer), SMMC-7721 (human liver cancer) and SW480 (human rectal cancer) cell lines were evaluated. Piperchabamide B (11) exhibited weak inhibitory activity against HL-60 (IC₅₀=21.32 μM), A-549 (IC₅₀=23.82 μM) and MCF-7 (IC₅₀=16.58 μM) cell lines.

Key words: Piperaceae, Piper longum, amide alkaloids, piperlongumamides, piperchabamide B, cytotoxicity

Jun YANG, Yao SU, Ji-Feng LUO, Wei GU, Hong-Mei NIU, Yan LI, Yue-Hu WANG, Chun-Lin LONG. New amide alkaloids from Piper longum fruits[J]. 应用天然产物, 2013, 3(6): 277-281.

Jun YANG, Yao SU, Ji-Feng LUO, Wei GU, Hong-Mei NIU, Yan LI, Yue-Hu WANG, Chun-Lin LONG. New amide alkaloids from Piper longum fruits[J]. Natural Products and Bioprospecting, 2013, 3(6): 277-281.

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New amide alkaloids from Piper longum fruits

New amide alkaloids from Piper longum fruits

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