应用天然产物 ›› 2012, Vol. 2 ›› Issue (6): 240-244.DOI: 10.1007/s13659-012-0058-4
Shuang WANGa,b, Ling ZHANGa, Liang-Yan LIUa,b, Ze-Jun DONGa, Zheng-Hui LIa, Ji-Kai LIUa
收稿日期:2012-07-17
修回日期:2012-10-08
出版日期:2012-12-24
发布日期:2018-02-11
通讯作者:
Ji-Kai LIU,E-mail:jkliu@mail.kib.ac.cn
基金资助:Shuang WANGa,b, Ling ZHANGa, Liang-Yan LIUa,b, Ze-Jun DONGa, Zheng-Hui LIa, Ji-Kai LIUa
Received:2012-07-17
Revised:2012-10-08
Online:2012-12-24
Published:2018-02-11
Supported by:摘要： Investigation of the culture of basidiomycete Polyporus ellisii led to the isolation of a novel compound 3β, 9α, 15α-trihydroxy-(22E, 24R)-10(5→4)-abeo-ergosta-6, 8(14), 22-trien-5-one(1) with a new 5/7/6/5 ring system of ergosterol skeleton. In addition, five new steroids, 5β, 6β-epoxy-3β, 7α, 9α-trihydroxy-(22E, 24R)-ergosta-8(14), 22-dien-15-one(2), 5β, 6β-epoxy-3β, 7α-dihydroxy-(22E, 24R)-ergosta-8(14), 22-dien-15-one(3), 5α, 6α-epoxy-3β, 9α, 15α-trihydroxy-(22E, 24R)-ergosta-8(14), 22-dien-7-one(4), 15α-acetoxy-(22E, 24R)-ergosta-4, 6, 8(14), 22-tetraen-3-one(5), 15β-methoxy-(22E, 24R)-ergosta-4, 6, 8(14), 22-tetraen-3-one(6), along with four known ergosterols(7-10), were obtained. All structures were elucidated based on 1D and 2D NMR spectral data. New compounds were evaluated for cytotoxicity against five human cancer cell lines, only compound 4 was found to exhibit a favorable cytotoxicity profile toward all tested tumor cell lines.
Shuang WANG, Ling ZHANG, Liang-Yan LIU, Ze-Jun DONG, Zheng-Hui LI, Ji-Kai LIU. Six novel steroids from culture of basidiomycete Polyporus ellisii[J]. 应用天然产物, 2012, 2(6): 240-244.
Shuang WANG, Ling ZHANG, Liang-Yan LIU, Ze-Jun DONG, Zheng-Hui LI, Ji-Kai LIU. Six novel steroids from culture of basidiomycete Polyporus ellisii[J]. Natural Products and Bioprospecting, 2012, 2(6): 240-244.
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