Chemical constituents from Munronia sinica and their bioactivities

doi:10.1007/s13659-012-0001-8

应用天然产物 ›› 2012, Vol. 2 ›› Issue (2): 76-80.DOI: 10.1007/s13659-012-0001-8

• Regular Article • 上一篇下一篇

Chemical constituents from Munronia sinica and their bioactivities

Xiao-Li LI^a,b, Qiu-Xia HE^c, Feng-Lei ZHANG^d, Yan-Li ZHAO^a,b, Ke-Chun LIU^c, Si-Ping JIANG^,e

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b State Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
c Biology Institute of Shandong Academy of Sciences, Jinan 250014, China;
d Kunming City Institute of Materia Medica, Kunming 650051, China;
e Plateau Institute of Biology, Lhasa 850000, China

收稿日期:2012-01-01 修回日期:2012-03-16 出版日期:2012-04-24 发布日期:2018-02-11
通讯作者: Xiao-Li LI,E-mail:li_xiaoli11@mail.kib.ac.cn
基金资助:
This project was supported financially by the Bureau of Science and Technology of Kunming City.

Chemical constituents from Munronia sinica and their bioactivities

Xiao-Li LI^a,b, Qiu-Xia HE^c, Feng-Lei ZHANG^d, Yan-Li ZHAO^a,b, Ke-Chun LIU^c, Si-Ping JIANG^,e

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b State Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
c Biology Institute of Shandong Academy of Sciences, Jinan 250014, China;
d Kunming City Institute of Materia Medica, Kunming 650051, China;
e Plateau Institute of Biology, Lhasa 850000, China

Received:2012-01-01 Revised:2012-03-16 Online:2012-04-24 Published:2018-02-11
Supported by:
This project was supported financially by the Bureau of Science and Technology of Kunming City.

摘要/Abstract

摘要： Two new minor constituents, musinisins A(1) and B(2), together with five known compounds(3-7), were isolated from the aerial parts of Munronia sinica. Their structures were established by means of spectroscopic methods and the absolute stereochemistry of 1 was determined by single crystal X-ray experiment. Compound 4 showed antiangiogenic activity evaluated by a zebrafish model and apoptosis-inducing effect on A549 lung cancer cells.

关键词: Munronia sinica, chemical constituent, musinisin, antiangiogenic activity

Abstract: Two new minor constituents, musinisins A(1) and B(2), together with five known compounds(3-7), were isolated from the aerial parts of Munronia sinica. Their structures were established by means of spectroscopic methods and the absolute stereochemistry of 1 was determined by single crystal X-ray experiment. Compound 4 showed antiangiogenic activity evaluated by a zebrafish model and apoptosis-inducing effect on A549 lung cancer cells.

Key words: Munronia sinica, chemical constituent, musinisin, antiangiogenic activity

Xiao-Li LI, Qiu-Xia HE, Feng-Lei ZHANG, Yan-Li ZHAO, Ke-Chun LIU, Si-Ping JIANG. Chemical constituents from Munronia sinica and their bioactivities[J]. 应用天然产物, 2012, 2(2): 76-80.

Xiao-Li LI, Qiu-Xia HE, Feng-Lei ZHANG, Yan-Li ZHAO, Ke-Chun LIU, Si-Ping JIANG. Chemical constituents from Munronia sinica and their bioactivities[J]. Natural Products and Bioprospecting, 2012, 2(2): 76-80.

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Chemical constituents from Munronia sinica and their bioactivities

Chemical constituents from Munronia sinica and their bioactivities

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