Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

doi:10.1007/s13659-011-0009-5

应用天然产物 ›› 2011, Vol. 1 ›› Issue (1): 48-51.DOI: 10.1007/s13659-011-0009-5

• Regular Article • 上一篇下一篇

Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

Kang HE^a,b, Yun-Bao MA^a, Chang-An GENG^a, Xue-Mei ZHANG^a, Tuan-Wu CAO^a,b, Fu-Qiang JIANG^a,b, Ji-Jun CHEN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China

收稿日期:2011-07-08 修回日期:2011-08-08 出版日期:2011-01-29 发布日期:2017-11-10
通讯作者: Ji-Jun CHEN,E-mail:chenjj@mail.kib.ac.cn
基金资助:
This work was financially supported by the National Natural Sciences Foundation of China for Distinguished Young Scholar(No. 81025023). The authors are grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for the measurements of all spectra.

Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

Kang HE^a,b, Yun-Bao MA^a, Chang-An GENG^a, Xue-Mei ZHANG^a, Tuan-Wu CAO^a,b, Fu-Qiang JIANG^a,b, Ji-Jun CHEN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100039, China

Received:2011-07-08 Revised:2011-08-08 Online:2011-01-29 Published:2017-11-10
Supported by:
This work was financially supported by the National Natural Sciences Foundation of China for Distinguished Young Scholar(No. 81025023). The authors are grateful to the staff of the analytical group of the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for the measurements of all spectra.

摘要/Abstract

摘要： Three new secoiridoids, swertiakoulactone(1) and swertiakosides A and B(2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus(HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion(IC₅₀=1.10 mM, SI=4.39) and HBV DNA replication(IC₅₀=1.16 mM, SI=4.12).

关键词: Swertia kouitchensis, anti-HBV activity, swertiakoulactone, swertiakoside A, swertiakoside B

Abstract: Three new secoiridoids, swertiakoulactone(1) and swertiakosides A and B(2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus(HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion(IC₅₀=1.10 mM, SI=4.39) and HBV DNA replication(IC₅₀=1.16 mM, SI=4.12).

Key words: Swertia kouitchensis, anti-HBV activity, swertiakoulactone, swertiakoside A, swertiakoside B

Kang HE, Yun-Bao MA, Chang-An GENG, Xue-Mei ZHANG, Tuan-Wu CAO, Fu-Qiang JIANG, Ji-Jun CHEN. Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis[J]. 应用天然产物, 2011, 1(1): 48-51.

Kang HE, Yun-Bao MA, Chang-An GENG, Xue-Mei ZHANG, Tuan-Wu CAO, Fu-Qiang JIANG, Ji-Jun CHEN. Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis[J]. Natural Products and Bioprospecting, 2011, 1(1): 48-51.

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[3]	Chang-An GENG, Xue-Mei ZHANG, Yun-Bao MA, Xiao-Yan HUANG, Ji-Jun CHEN. Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis[J]. 应用天然产物, 2013, 3(5): 243-249.

Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

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