整合生物学期刊网

应用天然产物 ›› 2011, Vol. 1 ›› Issue (1): 52-56.DOI: 10.1007/s13659-011-0013-9

• Regular Article • 上一篇    下一篇

Cyclopeptides from Amanita exitialis

Jing-Hua XUE, Ping WU, Yu-Lang CHI, Liang-Xiong XU, Xiao-Yi WEI   

  1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China
  • 收稿日期:2011-08-30 修回日期:2011-09-04 出版日期:2011-01-29 发布日期:2017-11-10
  • 通讯作者: Xiao-Yi WEI,E-mail:wxy@scbg.ac.cn
  • 基金资助:
    This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(No. KSCX2-YW-N-036).

Cyclopeptides from Amanita exitialis

Jing-Hua XUE, Ping WU, Yu-Lang CHI, Liang-Xiong XU, Xiao-Yi WEI   

  1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, China
  • Received:2011-08-30 Revised:2011-09-04 Online:2011-01-29 Published:2017-11-10
  • Supported by:
    This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(No. KSCX2-YW-N-036).

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摘要： A new cyclic nonapeptide, amanexitide(1), along with the known cyclopeptides, α-and β-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides.

关键词: Amanita, Amanita exitialis, cyclopeptides, amanexitide

Abstract: A new cyclic nonapeptide, amanexitide(1), along with the known cyclopeptides, α-and β-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides.

Key words: Amanita, Amanita exitialis, cyclopeptides, amanexitide

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