Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

Wen-Xing LIU; Gui-Hua TANG; Hong-Ping HE; Yu ZHANG; Shun-Lin LI; Xiao-Jiang HAO

doi:10.1007/s13659-011-0030-8

Natural Products and Bioprospecting >

2012 , Vol. 2 >Issue 1: 29 - 34

DOI: https://doi.org/10.1007/s13659-011-0030-8

Regular Article

Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

Wen-Xing LIU ,
Gui-Hua TANG ,
Hong-Ping HE ,
Yu ZHANG ,
Shun-Lin LI ,
Xiao-Jiang HAO

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a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received date: 2011-11-09

Revised date: 2011-02-13

Online published: 2018-02-11

Supported by

This work was supported by grants from the Ministry of Science and Technology(2009CB522300 and 2009CB940900).

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Abstract

Four new limonoids, dysohainanins A-D(1-4), and two new triterpenoids, dysohainanins E and F(5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4, 16, 18-trihydroxy-8(14)-pomaren-15-one(13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC₅₀ values of 24.3, 28.1, 30.7, and 22.5 μM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive.

Key words： Dysoxylum hainanense; Meliaceae; limonoids; triterpenoids; cytotoxicity

Cite this article

Wen-Xing LIU , Gui-Hua TANG , Hong-Ping HE , Yu ZHANG , Shun-Lin LI , Xiao-Jiang HAO . Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense[J]. Natural Products and Bioprospecting, 2012 , 2(1) : 29 -34 . DOI: 10.1007/s13659-011-0030-8

References

[1] Duh, C. Y.; Wang, S. K.; Chen, I. S. J. Nat. Prod. 2000, 63, 1546-547.
[2] Chen, J. L.; Kernan, M. R.; Jolad, S. D.; Stoddart, C. A.; Bogan, M.; Cooper, R. J. Nat. Prod. 2007, 70, 312-315.
[3] Aladesanmi, A. J.; Ilesanmi, O. R. J. Nat. Prod. 1987, 50, 1041-1044.
[4] Kashiwada, Y.; Fujioka, T.; Chang, J. J.; Chen, I. S.; Mihashi, K. M.; Lee, K. H. J. Org. Chem. 1992, 57, 6946-6953.
[5] Versha, P.; Manoj, G.; Bajaj, B. K. Indian Perfumer 2003, 47, 183-187.
[6] Luo, X. D.; Wu, S. H.; Wu, D. G.; Ma, Y. B.; Qi, S. H. Tetrahedron 2002, 58, 7797-7804.
[7] He, X. F.; Wang, X. N.; Yin, S.; Dong, L.; Yue, J. M. Eur. J. Org. Chem. 2009, 2009, 4818-4824.
[8] Luo, X. D.; Wu, S. H.; Ma, Y. B.; Wu, D. G. Phytochemstry 2000, 54, 801-805.
[9] Luo, X. D.; Wu, S. H.; Ma, Y. B.; Wu, D. G. Phytochemstry 2001, 57, 131-134.
[10] Luo, X. D.; Wu, S. H.; Ma, Y. B.; Wu, D. G. Acta Bot. Yunnan. 2001, 23, 368-372.
[11] Luo, X. D.; Wu, S. H.; Yang, X. S.; Teng, R. W.; Ma, Y. B.; Wu, D. G.; Hao, X. J.; Lu, Y.; Liu, X. Y.; Zheng, Q. T. Heterocycles 2000, 53, 2225-2232.
[12] He, X. F.; Wang, X. N.; Gan, L. S.; Yin, S.; Dong, L.; Yue, J. M. Org. Lett. 2008, 10, 4327-4330.
[13] He, X. F.; Wang, X. N.; Yin, S.; Dong, L.; Yue, J. M. Bioorg. Med. Chem. Lett. 2011, 21, 125-129.
[14] Zhang, X. Y.; Zhang, R. T.; Cai, X. H.; Liu, Y. P.; Luo, X. D. Z. Naturforsch. B 2010, 65, 1161-1163.
[15] Pudhom, K.; Sommit, D.; Nuclear, P.; Ngamrojanavanich, N.; Petson, A. J. Nat. Prod. 2009, 72, 2188-2191.
[16] Singh, Y.; Aalbersberg, W. Phytochemstry 1992, 31, 4033-4035.
[17] Wang, X. N.; Fan, C. Q.; Yin, S.; Lin, L. P.; Ding, J.; Yue, J. M. Helv. Chim. Acta 2008, 91, 510-519.
[18] Monks, A.; Scudiero, D.; Skehan, P.; Shoemaker, R.; Paull, K.; Vistica, D.; Hose, C.; Langley, J.; Cronise, P.; Vaigro, W. J. Natl. Cancer Inst. 1991, 83, 757-766.
[19] Wang, Z. Q.; Zhou, H.; Han, J.; He, Y. Q.; Lu, L. P. Agrochemicals 2011, 50, 261-262, 275.

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