Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans

doi:10.1007/s13659-026-00604-4

Natural Products and Bioprospecting ›› 2026, Vol. 16 ›› Issue (4): 56-56.DOI: 10.1007/s13659-026-00604-4

• ORIGINAL ARTICLES • Previous Articles Next Articles

Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans

Stéfano Romussi^1,2, Ailin Lacour^1,2, Diego Rayes^1,2, María José De Rosa^1,2

1. Laboratorio Neurobiología de Invertebrados, Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB) CCT UNS-CONICET, 8000, Camino La Carrindanga Km 7, Buenos Aires, 8000, Bahía Blanca, Argentina;
2. Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), 8000, San Juan 670, Buenos Aires, 8000, Bahía Blanca, Argentina

Received:2025-12-23 Accepted:2026-02-05 Online:2026-08-29 Published:2026-08-22
Contact: Diego Rayes,E-mail:drayes@criba.edu.ar;María José De Rosa,E-mail:mjderosa@criba.edu.ar
Supported by:
This work was supported by Grants from: 1) Universidad Nacional Del Sur to DR (PGI: 24/B291), MJDR (PGI: 24/B261) 2) Agencia Nacional de Promoción de la Ciencia y la Tecnología ANPCYT Argentina to DR (PICT 2019-0480 and PICT-2021-I-A-00052), MJDR (PICT 2020 1734) and Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina to DR and MJDR (PIPNo. 11220200101606CO).

Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans

Stéfano Romussi^1,2, Ailin Lacour^1,2, Diego Rayes^1,2, María José De Rosa^1,2

1. Laboratorio Neurobiología de Invertebrados, Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB) CCT UNS-CONICET, 8000, Camino La Carrindanga Km 7, Buenos Aires, 8000, Bahía Blanca, Argentina;
2. Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), 8000, San Juan 670, Buenos Aires, 8000, Bahía Blanca, Argentina

通讯作者: Diego Rayes,E-mail:drayes@criba.edu.ar;María José De Rosa,E-mail:mjderosa@criba.edu.ar
基金资助:
This work was supported by Grants from: 1) Universidad Nacional Del Sur to DR (PGI: 24/B291), MJDR (PGI: 24/B261) 2) Agencia Nacional de Promoción de la Ciencia y la Tecnología ANPCYT Argentina to DR (PICT 2019-0480 and PICT-2021-I-A-00052), MJDR (PICT 2020 1734) and Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina to DR and MJDR (PIPNo. 11220200101606CO).

Abstract

Abstract: Oxidative stress (OS) is a major contributor to aging and the pathogenesis of numerous conditions, including diabetes, neurodegenerative, cardiovascular, and autoimmune disorders. Consequently, therapeutic strategies aimed at enhancing endogenous cytoprotective pathways have gained significant interest. Plant-derived essential oils represent attractive sources for such interventions due to their natural origin and low toxicity; specifically, the monoterpenoid geraniol, a principal component of rose oil, has demonstrated promising antioxidant properties in vitro. In this study, we utilized Caenorhabditis elegans to investigate the in vivo efficacy and molecular mechanisms of geraniol effect. Our results show that geraniol significantly reduces intracellular reactive oxygen species and enhances resistance to acute OS induced by juglone. Mechanistic characterization using GFP-reporter strains revealed that geraniol activates the DAF-16/FOXO and SKN-1/Nrf2 transcription factors, while surprisingly causing a slight but consistent downregulation of the HSF-1-mediated heat-shock response. Crucially, genetic epistasis analysis using null/hypomorphic mutants demonstrated that only SKN-1 is strictly essential for geraniol-mediated protection against induced OS. In conclusion, this study underscores the utility of C. elegans as a robust and accessible platform for the pharmacological screening of natural products. Our findings establish geraniol, a key constituent of rose oil, as a multifunctional modulator of cellular defenses that orchestrates multiple cytoprotective pathways, identifying the SKN-1-dependent response as a critical driver of its antioxidant efficacy in C. elegans. By delineating this specific genetic requirement, these results provide a mechanistic foundation that supports the therapeutic potential of geraniol in mitigating aging and pathophysiology driven by OS.

Key words: Caenorhabditis elegans, Antioxidant, Essential oil, Cytoprotective mechanism, Oxidative stress

摘要： Oxidative stress (OS) is a major contributor to aging and the pathogenesis of numerous conditions, including diabetes, neurodegenerative, cardiovascular, and autoimmune disorders. Consequently, therapeutic strategies aimed at enhancing endogenous cytoprotective pathways have gained significant interest. Plant-derived essential oils represent attractive sources for such interventions due to their natural origin and low toxicity; specifically, the monoterpenoid geraniol, a principal component of rose oil, has demonstrated promising antioxidant properties in vitro. In this study, we utilized Caenorhabditis elegans to investigate the in vivo efficacy and molecular mechanisms of geraniol effect. Our results show that geraniol significantly reduces intracellular reactive oxygen species and enhances resistance to acute OS induced by juglone. Mechanistic characterization using GFP-reporter strains revealed that geraniol activates the DAF-16/FOXO and SKN-1/Nrf2 transcription factors, while surprisingly causing a slight but consistent downregulation of the HSF-1-mediated heat-shock response. Crucially, genetic epistasis analysis using null/hypomorphic mutants demonstrated that only SKN-1 is strictly essential for geraniol-mediated protection against induced OS. In conclusion, this study underscores the utility of C. elegans as a robust and accessible platform for the pharmacological screening of natural products. Our findings establish geraniol, a key constituent of rose oil, as a multifunctional modulator of cellular defenses that orchestrates multiple cytoprotective pathways, identifying the SKN-1-dependent response as a critical driver of its antioxidant efficacy in C. elegans. By delineating this specific genetic requirement, these results provide a mechanistic foundation that supports the therapeutic potential of geraniol in mitigating aging and pathophysiology driven by OS.

关键词: Caenorhabditis elegans, Antioxidant, Essential oil, Cytoprotective mechanism, Oxidative stress

Stéfano Romussi, Ailin Lacour, Diego Rayes, María José De Rosa. Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans[J]. Natural Products and Bioprospecting, 2026, 16(4): 56-56.

References

[1] Bordoni M, Scarian E, Rey F, Gagliardi S, Carelli S, Pansarasa O, et al. Biomaterials in neurodegenerative disorders: a promising therapeutic approach. Int J Mol Sci. 2020. https://doi.org/10.3390/ijms21093243.
[2] Espinós C, Galindo MI, García-Gimeno MA, Ibáñez-Cabellos JS, Martínez-Rubio D, Millán JM, et al. Oxidative stress, a crossroad between rare diseases and neurodegeneration. Antioxidants. 2020. https://doi.org/10.3390/antiox9040313.
[3] Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809):239-47. https://doi.org/10.1038/35041687.
[4] Ewald CY, Hourihan JM, Bland MS, Obieglo C, Katic I, Moronetti Mazzeo LE, et al. NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans. Elife. 2017. https://doi.org/10.7554/eLife.19493.
[5] Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB. Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 2014;20(7):1126-67. https://doi.org/10.1089/ars.2012.5149.
[6] Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-72. https://doi.org/10.2147/CIA.S158513.
[7] Baptista-Silva S, Borges S, Ramos OL, Pintado M, Sarmento B. The progress of essential oils as potential therapeutic agents: a review. J Essent Oil Res. 2020;32(4):279-95. https://doi.org/10.1080/10412905.2020.1746698.
[8] Mancianti F, Ebani VV. Biological activity of essential oils. Molecules. 2020. https://doi.org/10.3390/molecules25030678.
[9] Banu F, Dawood N, Lakshmi YSL, Sivaraman G, Brinda V. Antioxidant activity of geraniol on N-nitrosodiethylamine-induced hepatocarcinogenesis in wistar albino rats. Ind J Oncol Radiat Biol. 2014;2:4-9.
[10] Mączka W, Wińska K, Grabarczyk M. One hundred faces of geraniol. Molecules. 2020;25:3303. https://doi.org/10.3390/molecules25143303.
[11] De Fazio L, Spisni E, Cavazza E, Strillacci A, Candela M, Centanni M, et al. Dietary geraniol by oral or enema administration strongly reduces dysbiosis and systemic inflammation in dextran sulfate sodium-treated mice. Front Pharmacol. 2016;7:38. https://doi.org/10.3389/fphar.2016.00038.
[12] Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366(6454):461-4. https://doi.org/10.1038/366461a0.
[13] Samuelson AV, Carr CE, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007;21(22):2976-94. https://doi.org/10.1101/gad.1588907.
[14] Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC. Green fluorescent protein as a marker for gene expression. Science. 1994;263(5148):802-5. https://doi.org/10.1126/science.263.5148.802.
[15] Kerr RA, Schafer WR. Intracellular Ca²⁺ imaging in C. elegans. In: Strange K, editor. C. elegans. Methods in Molecular Biology. Totowa (NJ): Humana Press; 2006. pp. 253-264. https://doi.org/10.1385/1-59745-151-7:253.
[16] Kenyon CJ. The genetics of ageing. Nature. 2010;464(7288):504-12. https://doi.org/10.1038/nature08980.
[17] Fontana L, Partridge L, Longo VD. Extending healthy life span--from yeast to humans. Science. 2010;328(5976):321-6. https://doi.org/10.1126/science.1172539.
[18] Cohen E, Dillin A. The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci. 2008;9(10):759-67. https://doi.org/10.1038/nrn2474.
[19] Hsu AL, KENYy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 2003;300(5622):1142-5. https://doi.org/10.1126/science.1083701.
[20] Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science. 2006;313(5793):1604-10. https://doi.org/10.1126/science.1124646.
[21] Anckar J, Sistonen L. Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem. 2011;80:1089-115. https://doi.org/10.1146/annurev-biochem-060809-095203.
[22] Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, et al. Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. Elife. 2015;4:e07836. https://doi.org/10.7554/eLife.07836.
[23] Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaca JL, Dias N, et al. Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet. 2011;20(15):2996-3009. https://doi.org/10.1093/hmg/ddr203.
[24] Andersen N, Veuthey T, Blanco MG, Silbestri GF, Rayes D, De Rosa MJ. 1-mesityl-3-(3-sulfonatopropyl) imidazolium protects against oxidative stress and delays proteotoxicity in C. elegans. Front Pharmacol. 2022;13:908696. https://doi.org/10.3389/fphar.2022.908696.
[25] Giunti S, Andersen N, Rayes D, De Rosa MJ. Drug discovery: insights from the invertebrate Caenorhabditis elegans. Pharmacol Res Perspect. 2021;9(2):e00721. https://doi.org/10.1002/prp2.721.
[26] Lakso M, Vartiainen S, Moilanen AM, Sirvio J, Thomas JH, Nass R, et al. Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein. J Neurochem. 2003;86(1):165-72. https://doi.org/10.1046/j.1471-4159.2003.01809.x.
[27] Simonetta SH, Golombek DA. An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies application. J Neurosci Methods. 2007;161(2):273-80. https://doi.org/10.1016/j.jneumeth.2006.11.015.
[28] Knoefler D, Thamsen M, Koniczek M, Niemuth NJ, Diederich AK, Jakob U. Quantitative in vivo redox sensors uncover oxidative stress as an early event in life. Mol Cell. 2012;47(5):767-76. https://doi.org/10.1016/j.molcel.2012.06.016.
[29] Back P, Matthijssens F, Vanfleteren JR, Braeckman BP. A simplified hydroethidine method for fast and accurate detection of superoxide production in isolated mitochondria. Anal Biochem. 2012;423(1):147-51. https://doi.org/10.1016/j.ab.2012.01.008.
[30] Swindell WR. Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev. 2012;11(2):254-70. https://doi.org/10.1016/j.arr.2011.12.006.
[31] Ching TT, Hsu AL. The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans. J Biomed Sci. 2025;32(1):91. https://doi.org/10.1186/s12929-025-01188-w.
[32] Murphy CT, Hu PJ. Insulin/insulin-like growth factor signaling in C. elegans. In: WormBook, editor. WormBook. [Place unknown]: WormBook; 2013. pp. 1-43. https://doi.org/10.1895/wormbook.1.164.1
[33] Altintas O, Park S, Lee SJ. The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster. BMB Rep. 2016;49(2):81-92.
[34] Kumsta C, Chang JT, Schmalz J, Hansen M. Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans. Nat Commun. 2017;8:14337. https://doi.org/10.1038/ncomms14337.
[35] De Rosa MJ, Veuthey T, Florman J, Grant J, Blanco MG, Andersen N, et al. The flight response impairs cytoprotective mechanisms by activating the insulin pathway. Nature. 2019;573(7772):135-8. https://doi.org/10.1038/s41586-019-1524-5.
[36] Veuthey T, Florman JT, Giunti S, Romussi S, De Rosa MJ, Alkema MJ, et al. The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response. PLoS Biol. 2025;23(1):e3002997. https://doi.org/10.1371/journal.pbio.3002997.
[37] Kovacs D, Biro JB, Ahmed S, Kovacs M, Sigmond T, Hotzi B, et al. Age-dependent heat shock hormesis to HSF-1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegans. Aging Cell. 2024;23(10):e14246. https://doi.org/10.1111/acel.14246.
[38] Chen W, Viljoen A. Geraniol—a review of a commercially important fragrance material. S Afr J Bot. 2010;76:643-51. https://doi.org/10.1016/j.sajb.2010.05.008.
[39] de Cássia da Silveira e Sá R, Andrade LN, de Sousa DP. A review on anti-inflammatory activity of monoterpenes. Molecules. 2013;18(1):1227-54. https://doi.org/10.3390/molecules18011227.
[40] Sato K, Krist S, Buchbauer G. Antimicrobial effect of vapours of geraniol, (R)-(-)-linalool, terpineol, γ-terpinene and 1,8-cineole on airborne microbes using an airwasher. Flavour Fragr J. 2007;22(5):435-7. https://doi.org/10.1002/ffj.1818.
[41] Papachristos DP, Karamanoli KI, Stamopoulos DC, Menkissoglu-Spiroudi U. The relationship between the chemical composition of three essential oils and their insecticidal activity against Acanthoscelides obtectus (Say). Pest Manag Sci. 2004;60(5):514-20. https://doi.org/10.1002/ps.798.
[42] Morales-Serna FN, Martínez-Brown JM, Avalos-Soriano A, Sarmiento-Vázquez S, Hernández-Inda ZL, Medina-Guerrero RM, et al. The efficacy of geraniol and β-citronellol against freshwater and marine monogeneans. J Aquat Anim Health. 2020;32(3):127-32. https://doi.org/10.1002/aah.10109.
[43] Galle M, Crespo R, Kladniew BR, Villegas SM, Polo M, de Bravo MG. Suppression by geraniol of the growth of A549 human lung adenocarcinoma cells and inhibition of the mevalonate pathway in vitro and in vivo: potential use in cancer chemotherapy. Nutr Cancer. 2014;66(5):888-95. https://doi.org/10.1080/01635581.2014.916320.
[44] Manful CF, Fordjour E, Subramaniam D, Sey AA, Abbey L, Thomas R. Antioxidants and reactive oxygen species: shaping human health and disease outcomes. Int J Mol Sci. 2025;26(15):7520. https://doi.org/10.3390/ijms26157520.
[45] Wei Y, Jia S, Ding Y, Xia S, Giunta S. Balanced basal-levels of ROS (redox-biology), and very-low-levels of pro-inflammatory cytokines (cold-inflammaging), as signaling molecules can prevent or slow-down overt-inflammaging, and the aging-associated decline of adaptive-homeostasis. Exp Gerontol. 2023;172:112067. https://doi.org/10.1016/j.exger.2022.112067.
[46] Avery L. The genetics of feeding in Caenorhabditis elegans. Genetics. 1993;133(4):897-917. https://doi.org/10.1093/genetics/133.4.897.
[47] Wang FY, Ching TT. Oil red o staining for lipid content in Caenorhabditis elegans. Bio Protoc. 2021;11(16):e4124. https://doi.org/10.21769/BioProtoc.4124.
[48] Park SK, Tedesco PM, Johnson TE. Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell. 2009;8(3):258-69. https://doi.org/10.1111/j.1474-9726.2009.00473.x.
[49] Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet. 2006;38(2):251-7. https://doi.org/10.1038/ng1723.
[50] Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 2015;519(7541):97-101. https://doi.org/10.1038/nature14021.
[51] Klotz LO, Steinbrenner H. Cellular adaptation to xenobiotics: interplay between xenosensors, reactive oxygen species and FOXO transcription factors. Redox Biol. 2017;13:646-54. https://doi.org/10.1016/j.redox.2017.07.015.
[52] Gille A, Turkistani A, Tsitsipatis D, Hou X, Tauber S, Hamann I, et al. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 2019;20:19-27. https://doi.org/10.1016/j.redox.2018.09.010.
[53] An JH, Blackwell TK. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 2003;17(15):1882-93. https://doi.org/10.1101/gad.1107803.
[54] Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 2002;62(18):5196-203. https://doi.org/10.1158/0008-5472.CAN-02-1943.
[55] Hayes JD, McMahon M. Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett. 2001;174(2):103-13. https://doi.org/10.1016/S0304-3835(01)00695-4.
[56] Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997;236(2):313-22. https://doi.org/10.1006/bbrc.1997.6943.
[57] Chan K, Kan YW. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci U S A. 1999;96(22):12731-6. https://doi.org/10.1073/pnas.96.22.12731.
[58] Chan K, Han XD, Kan YW. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci U S A. 2001;98(8):4611-6. https://doi.org/10.1073/pnas.081082098.
[59] Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001;98(6):3410-5. https://doi.org/10.1073/pnas.051618798.
[60] Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci U S A. 2002;99(11):7610-5. https://doi.org/10.1073/pnas.112203099.
[61] Perić M, Bou Dib P, Dennerlein S, Musa M, Rudan M, Lovrić A, et al. Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan. Sci Rep. 2016;6:28751. https://doi.org/10.1038/srep28751.
[62] Deng J, Dai Y, Tang H, Pang S. SKN-1 is a negative regulator of DAF-16 and somatic stress resistance in Caenorhabditis elegans. G3 Genes|Genomes|Genetics. 2020;10(5):1707-12. https://doi.org/10.1534/g3.120.401203.
[63] Nakae J, Park BC, Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a wortmannin-sensitive pathway. J Biol Chem. 1999;274(23):15982-5. https://doi.org/10.1074/jbc.274.23.15982.
[64] Brenner S. The genetics of Caenorhabditis elegans. Genetics. 1974;77(1):71-94.
[65] Stiernagle T. Maintenance of C. elegans. In: WormBook, editor. WormBook. [Place unknown]: WormBook; 2006. pp. 1-11. https://doi.org/10.1895/wormbook.1.101.1.
[66] Blanco MG, Vela Gurovic MS, Silbestri GF, Garelli A, Giunti S, Rayes D, et al. Diisopropylphenyl-imidazole (DII): a new compound that exerts anthelmintic activity through novel molecular mechanisms. PLoS Negl Trop Dis. 2018;12(12):e0007021. https://doi.org/10.1371/journal.pntd.0007021.
[67] AlOkda A, Van Raamsdonk JM. Effect of DMSO on lifespan and physiology in C. elegans: implications for use of DMSO as a solvent for compound delivery. MicroPubl Biol. 2022;2022. https://doi.org/10.17912/micropub.biology.000634.
[68] Back P, De Vos WH, Depuydt GG, Matthijssens F, Vanfleteren JR, Braeckman BP. Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans. Free Radic Biol Med. 2012;52(5):850-9. https://doi.org/10.1016/j.freeradbiomed.2011.11.037.
[69] Daina A, Michielin O, Zoete V. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep. 2017;7:42717. https://doi.org/10.1038/srep42717.

Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans

Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Nosiba A. Alsarayrah, Rafeezul Mohamed, Eshaifol A. Omar. Stingless bee propolis: a comprehensive review of chemical constituents and health efficacy [J]. Natural Products and Bioprospecting, 2025, 15(6): 61-61.
[2]	Patricia Quintero-Rincón, Karina Caballero-Gallardo, Jesus Olivero-Verbel. Natural anticancer agents: prospection of medicinal and aromatic plants in modern chemoprevention and chemotherapy [J]. Natural Products and Bioprospecting, 2025, 15(3): 25-25.
[3]	Mukul Shyam, Evan Prince Sabina. Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications [J]. Natural Products and Bioprospecting, 2024, 14(6): 49-49.
[4]	Liz E. Lescano, Mario O. Salazar, Ricardo L. E. Furlan. Chemically engineered essential oils prepared through thiocyanation under solvent-free conditions: chemical and bioactivity alteration [J]. Natural Products and Bioprospecting, 2024, 14(5): 35-35.
[5]	Rudra Narayan Subudhi, Neelam Poonia, Dilpreet Singh, Vimal Arora. Natural approaches for the management of ulcerative colitis: evidence of preclinical and clinical investigations [J]. Natural Products and Bioprospecting, 2024, 14(5): 42-42.
[6]	Hai-Hui Guo, Lei Wu, Dan Mi, Xing-Yu Zhang, Fu-Mei He, Ting Lei, Fu-Sheng Wang. Polysaccharide fraction from Triplostegia glandulifera Wall and its renoprotective effect in streptozotocin-induced diabetic mice by attenuating oxidative stress [J]. Natural Products and Bioprospecting, 2024, 14(5): 47-47.
[7]	Srijan Banerjee, Gustavo Cabrera-Barjas, Jaime Tapia, João Paulo Fabi, Cedric Delattre, Aparna Banerjee. Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive [J]. Natural Products and Bioprospecting, 2024, 14(2): 3-3.
[8]	Heloísa H. S. Almeida, Pedro J. L. Crugeira, Joana S. Amaral, Alírio E. Rodrigues, Maria-Filomena Barreiro. Disclosing the potential of Cupressus leylandii A.B. Jacks & Dallim, Eucalyptus globulus Labill., Aloysia citrodora Paláu, and Melissa officinalis L. hydrosols as eco-friendly antimicrobial agents [J]. Natural Products and Bioprospecting, 2024, 14(1): 1-1.
[9]	Li Wu, Ning Yang, Meng Guo, Didi Zhang, Reza A. Ghiladi, Hasan Bayram, Jun Wang. The role of sound stimulation in production of plant secondary metabolites [J]. Natural Products and Bioprospecting, 2023, 13(6): 40-40.
[10]	Lingli Ding, Zhao Gao, Siluo Wu, Chen Chen, Yamei Liu, Min Wang, Yage Zhang, Ling Li, Hong Zou, Guoping Zhao, Shengnan Qin, Liangliang Xu. Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress [J]. Natural Products and Bioprospecting, 2023, 13(6): 49-49.
[11]	Tian Lan, Wen Wang, De-Lian Huang, Xi-Xi Zeng, Xiao-Xiao Wang, Jian Wang, Yu-Hua Tong, Zhu-Jun Mao, Si-Wei Wang. Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response [J]. Natural Products and Bioprospecting, 2023, 13(5): 36-36.
[12]	Teresa S. Catalá, Linn G. Speidel, Arlette Wenzel-Storjohann, Thorsten Dittmar, Deniz Tasdemir. Bioactivity profile of dissolved organic matter and its relation to molecular composition [J]. Natural Products and Bioprospecting, 2023, 13(5): 32-32.
[13]	Cintia Cristina Santi Martignago, Beatriz Soares-Silva, Julia Risso Parisi, Lais Caroline Souza e Silva, Renata Neves Granito, Alessandra Mussi Ribeiro, Ana Cláudia Muniz Renno, Lorena Ramos Freitas de Sousa, Anna Caroline Campos Aguiar. Terpenes extracted from marine sponges with antioxidant activity: a systematic review [J]. Natural Products and Bioprospecting, 2023, 13(4): 23-23.
[14]	Ding-kang Chen, Hui-yan Shao, Liu Yang, Jiang-miao Hu. The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3 [J]. Natural Products and Bioprospecting, 2022, 12(1): 1-11.
[15]	Soad Z. El-Emam. Sesamol Alleviates the Cytotoxic Effect of Cyclophosphamide on Normal Human Lung WI-38 Cells via Suppressing RAGE/NF-κB/Autophagy Signaling [J]. Natural Products and Bioprospecting, 2021, 11(3): 333-344.