Strophioglandins A-C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.04,13]tridecane core from Strophioblachia glandulosa var. cordifolia

doi:10.1007/s13659-025-00548-1

Natural Products and Bioprospecting ›› 2025, Vol. 15 ›› Issue (6): 65-65.DOI: 10.1007/s13659-025-00548-1

• Original Article • Previous Articles Next Articles

Strophioglandins A-C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.0^4,13]tridecane core from Strophioblachia glandulosa var. cordifolia

Jian-Kai Xia¹, Lei-Ming Wu¹, Wei-Ye Wu¹, Dong Huang¹, Fang-Yu Yuan¹, Lei Li¹, Shu-Qi Wu¹, Yan-Jiang Zhang¹, Tao Yuan², Xin Chen³, Gui-Hua Tang¹, Jia-Luo Huang¹, Sheng Yin¹

1. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China;
2. The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China;
3. School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, 430023, China

Received:2025-06-15 Online:2026-01-12
Contact: Jia-Luo Huang Email:E-mail:huangjluo3@mail.sysu.edu.cn
Supported by:
This work was funded by the National Natural Science Foundation of China (Nos. 82273804, 82304322, 82404454, and 22407144), the Science and Technology Program of Guangzhou, China (No. 2024B03J1322), the Science and Technology Planning Project of Guangdong Province, China (No. 2023A1111120025), the Postdoctoral Fellowship Program of CPSF (No. GZC20242113), the China Postdoctoral Science Foundation (No. 2024M753800), and Jiangxi “Double Thousand Plan” (No. JXSQ2023102240).

Strophioglandins A-C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.0^4,13]tridecane core from Strophioblachia glandulosa var. cordifolia

Jian-Kai Xia¹, Lei-Ming Wu¹, Wei-Ye Wu¹, Dong Huang¹, Fang-Yu Yuan¹, Lei Li¹, Shu-Qi Wu¹, Yan-Jiang Zhang¹, Tao Yuan², Xin Chen³, Gui-Hua Tang¹, Jia-Luo Huang¹, Sheng Yin¹

1. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China;
2. The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China;
3. School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, 430023, China

通讯作者: Jia-Luo Huang Email:E-mail:huangjluo3@mail.sysu.edu.cn
作者简介:Sheng Yin Email:E-mail:yinsh2@mail.sysu.edu.cn
基金资助:
This work was funded by the National Natural Science Foundation of China (Nos. 82273804, 82304322, 82404454, and 22407144), the Science and Technology Program of Guangzhou, China (No. 2024B03J1322), the Science and Technology Planning Project of Guangdong Province, China (No. 2023A1111120025), the Postdoctoral Fellowship Program of CPSF (No. GZC20242113), the China Postdoctoral Science Foundation (No. 2024M753800), and Jiangxi “Double Thousand Plan” (No. JXSQ2023102240).

Abstract

Abstract: Strophioglandins A-C (1-3), three highly rearranged norditerpenoids featuring an unusual tricyclo[6.4.1.0^4,13]tridecane core, were isolated from Strophioblachia glandulosa var. cordifolia. Integrated spectroscopic analyses, X-ray crystallography, and ECD calculations synergistically determined their molecular architectures. Remarkably, all compounds manifested potent anti-inflammatory effects in LPS-activated RAW264.7 cells with IC₅₀ values ranging from 7.83 ± 1.11 to 15.09 ± 1.21 μM. Mechanism study revealed that strophioglandin A (1), the most potent compound, could suppress the expression of multiple inflammatory factors by inhibiting the P38 and Erk1/2 MAPK signaling pathways.

Key words: Strophioblachia glandulosa var. cordifolia, Rearranged norditerpenoids, Anti-inflammatory effects, MAPK signaling pathways

摘要： Strophioglandins A-C (1-3), three highly rearranged norditerpenoids featuring an unusual tricyclo[6.4.1.0^4,13]tridecane core, were isolated from Strophioblachia glandulosa var. cordifolia. Integrated spectroscopic analyses, X-ray crystallography, and ECD calculations synergistically determined their molecular architectures. Remarkably, all compounds manifested potent anti-inflammatory effects in LPS-activated RAW264.7 cells with IC₅₀ values ranging from 7.83 ± 1.11 to 15.09 ± 1.21 μM. Mechanism study revealed that strophioglandin A (1), the most potent compound, could suppress the expression of multiple inflammatory factors by inhibiting the P38 and Erk1/2 MAPK signaling pathways.

关键词: Strophioblachia glandulosa var. cordifolia, Rearranged norditerpenoids, Anti-inflammatory effects, MAPK signaling pathways

Jian-Kai Xia, Lei-Ming Wu, Wei-Ye Wu, Dong Huang, Fang-Yu Yuan, Lei Li, Shu-Qi Wu, Yan-Jiang Zhang, Tao Yuan, Xin Chen, Gui-Hua Tang, Jia-Luo Huang, Sheng Yin. Strophioglandins A-C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.0^4,13]tridecane core from Strophioblachia glandulosa var. cordifolia[J]. Natural Products and Bioprospecting, 2025, 15(6): 65-65.

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Strophioglandins A-C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.0^4,13]tridecane core from Strophioblachia glandulosa var. cordifolia

Strophioglandins A-C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.0^4,13]tridecane core from Strophioblachia glandulosa var. cordifolia

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