Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023)

doi:10.1007/s13659-024-00493-5

Natural Products and Bioprospecting ›› 2025, Vol. 15 ›› Issue (2): 13-13.DOI: 10.1007/s13659-024-00493-5

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Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023)

Hesham R. El-Seedi^1,2,3,4, Mohamed S. Refaey⁵, Nizar Elias⁶, Mohamed F. El-Mallah⁴, Faisal M. K. Albaqami⁷, Ismail Dergaa⁸, Ming Du⁹, Mohamed F. Salem¹⁰, Haroon Elrasheid Tahir¹¹, Maria Dagliaa^2,12, Nermeen Yosri^13,14, Hongcheng Zhang¹⁵, Awg H. El-Seedi¹⁶, Zhiming Guo¹³, Shaden A. M. Khalifa^2,17

1. Department of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia;
2. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China;
3. International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu Education Department, Jiangsu University, Nanjing, 210024, China;
4. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt;
5. Department of Pharmacognosy, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt;
6. Department of Laboratory Medicine, Faculty of Medicine, University of Kalamoon, P. O. Box 222, Dayr Atiyah, Syria;
7. Biology Department, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia;
8. Primary Health Care Corporation (PHCC), Doha, Qatar;
9. School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian, 116034, China;
10. Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, GEBRI, University of Sadat City, P. O. Box:79, Sadat City, Egypt;
11. Agricultural Product Processing and Storage Lab, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, Jiangsu, China;
12. Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131, Naples, NA, Italy;
13. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China;
14. Chemistry Department of Medicinal and Aromatic Plants, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef, 62514, Egypt;
15. State Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, 100093, China;
16. International IT College of Sweden Stockholm, Arena Academy, H?lsobrunnsgatan 6, 11361, Stockholm, Sweden;
17. Psychiatry and Neurology Department, Capio Saint G?ran's Hospital, Sankt G?ransplan 1, 112 19, Stockholm, Sweden

Received:2024-05-18 Accepted:2024-12-16 Online:2025-05-17 Published:2025-04-25
Contact: Hesham R. El-Seedi, E-mail:elseedi_99@yahoo.com;Faisal M. K. Albaqami, E-mail:falbaqami@iu.edu.sa;Shaden A. M. Khalifa, E-mail:shaden.khalifa@regionstockholm.se

Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023)

1. Department of Chemistry, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia;
2. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China;
3. International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu Education Department, Jiangsu University, Nanjing, 210024, China;
4. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt;
5. Department of Pharmacognosy, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Egypt;
6. Department of Laboratory Medicine, Faculty of Medicine, University of Kalamoon, P. O. Box 222, Dayr Atiyah, Syria;
7. Biology Department, Faculty of Science, Islamic University of Madinah, 42351, Madinah, Saudi Arabia;
8. Primary Health Care Corporation (PHCC), Doha, Qatar;
9. School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian, 116034, China;
10. Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, GEBRI, University of Sadat City, P. O. Box:79, Sadat City, Egypt;
11. Agricultural Product Processing and Storage Lab, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, Jiangsu, China;
12. Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131, Naples, NA, Italy;
13. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China;
14. Chemistry Department of Medicinal and Aromatic Plants, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef, 62514, Egypt;
15. State Key Laboratory of Resource Insects, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, 100093, China;
16. International IT College of Sweden Stockholm, Arena Academy, H?lsobrunnsgatan 6, 11361, Stockholm, Sweden;
17. Psychiatry and Neurology Department, Capio Saint G?ran's Hospital, Sankt G?ransplan 1, 112 19, Stockholm, Sweden

通讯作者: Hesham R. El-Seedi, E-mail:elseedi_99@yahoo.com;Faisal M. K. Albaqami, E-mail:falbaqami@iu.edu.sa;Shaden A. M. Khalifa, E-mail:shaden.khalifa@regionstockholm.se

Abstract

Abstract: Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances made in the discovery and development of marine-derived anticancer drugs between 2019 and 2023. With a focus on recent research findings, the review explores the rich biodiversity of marine organisms, including sponges, corals, algae, and microorganisms, which have yielded numerous compounds exhibiting promising anticancer properties. Emphasizing the multifaceted mechanisms of action, the review discusses the molecular targets and pathways targeted by these compounds, such as cell cycle regulation, apoptosis induction, angiogenesis inhibition, and modulation of signaling pathways. Additionally, the review highlights the innovative strategies employed in the isolation, structural elucidation, and chemical modification of marine natural products to enhance their potency, selectivity, and pharmacological properties. Furthermore, it addresses the challenges and opportunities associated with the development of marine-derived anticancer drugs, including issues related to supply, sustainability, synthesis, and clinical translation. Finally, the review underscores the immense potential of marine natural products as a valuable reservoir of novel anticancer agents and advocates for continued exploration and exploitation of the marine environment to address the unmet medical needs in cancer therapy

Key words: Marine natural products, Microorganism, Anticancer, Clinical trials, Drugs

摘要： Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. This review provides an updated overview of the significant advances made in the discovery and development of marine-derived anticancer drugs between 2019 and 2023. With a focus on recent research findings, the review explores the rich biodiversity of marine organisms, including sponges, corals, algae, and microorganisms, which have yielded numerous compounds exhibiting promising anticancer properties. Emphasizing the multifaceted mechanisms of action, the review discusses the molecular targets and pathways targeted by these compounds, such as cell cycle regulation, apoptosis induction, angiogenesis inhibition, and modulation of signaling pathways. Additionally, the review highlights the innovative strategies employed in the isolation, structural elucidation, and chemical modification of marine natural products to enhance their potency, selectivity, and pharmacological properties. Furthermore, it addresses the challenges and opportunities associated with the development of marine-derived anticancer drugs, including issues related to supply, sustainability, synthesis, and clinical translation. Finally, the review underscores the immense potential of marine natural products as a valuable reservoir of novel anticancer agents and advocates for continued exploration and exploitation of the marine environment to address the unmet medical needs in cancer therapy

关键词: Marine natural products, Microorganism, Anticancer, Clinical trials, Drugs

Hesham R. El-Seedi, Mohamed S. Refaey, Nizar Elias, Mohamed F. El-Mallah, Faisal M. K. Albaqami, Ismail Dergaa, Ming Du, Mohamed F. Salem, Haroon Elrasheid Tahir, Maria Dagliaa, Nermeen Yosri, Hongcheng Zhang, Awg H. El-Seedi, Zhiming Guo, Shaden A. M. Khalifa. Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023)[J]. Natural Products and Bioprospecting, 2025, 15(2): 13-13.

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Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023)

Marine natural products as a source of novel anticancer drugs: an updated review (2019-2023)

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