The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

doi:10.1007/s13659-017-0134-x

Natural Products and Bioprospecting ›› 2017, Vol. 7 ›› Issue (6): 421-431.DOI: 10.1007/s13659-017-0134-x

• ORIGINAL ARTICLES • Next Articles

The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

Pei-Feng Zhu^1,2,3, Zhi Dai^2,4, Bei Wang^1,2,3, Xin Wei^1,2,3, Hao-Fei Yu^1,2,3, Zi-Ru Yan^1,2,3, Xu-Dong Zhao⁴, Ya-Ping Liu^1,3, Xiao-Dong Luo^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
4 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China

Received:2017-04-07 Revised:2017-05-15 Online:2017-12-09 Published:2017-12-24
Contact: Ya-Ping Liu, Xiao-Dong Luo

The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

Pei-Feng Zhu^1,2,3, Zhi Dai^2,4, Bei Wang^1,2,3, Xin Wei^1,2,3, Hao-Fei Yu^1,2,3, Zi-Ru Yan^1,2,3, Xu-Dong Zhao⁴, Ya-Ping Liu^1,3, Xiao-Dong Luo^1,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
4 Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China

通讯作者: Ya-Ping Liu, Xiao-Dong Luo

Abstract

Abstract: Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides were identified from the stem of Lycium barbarum. The structures of the new compounds were determined by spectroscopic methods. All compounds were evaluated for their anti-cancer activities against human glioma stem cell lines.

Key words: Phenolic amides, Anticancer activities, Glioma stem cell

摘要： Four new phenolic amides, 4-O-methylgrossamide (1), (E)-2-(4,5-dihydroxy-2-{3-[(4-hydroxyphenethyl)amino]-3-oxopropyl}-phenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)acryl-amide (2), (Z)-lyciumamide C (3), (Z)-thoreliamide B (4), together with thirteen known phenolic amides were identified from the stem of Lycium barbarum. The structures of the new compounds were determined by spectroscopic methods. All compounds were evaluated for their anti-cancer activities against human glioma stem cell lines.

关键词: Phenolic amides, Anticancer activities, Glioma stem cell

Pei-Feng Zhu, Zhi Dai, Bei Wang, Xin Wei, Hao-Fei Yu, Zi-Ru Yan, Xu-Dong Zhao, Ya-Ping Liu, Xiao-Dong Luo. The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum[J]. Natural Products and Bioprospecting, 2017, 7(6): 421-431.

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The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

The Anticancer Activities Phenolic Amides from the Stem of Lycium barbarum

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