Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz

doi:10.1007/s13659-021-00302-3

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (4): 421-429.DOI: 10.1007/s13659-021-00302-3

• ORIGINAL ARTICLES • Previous Articles Next Articles

Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz

Na Zhang^1,2, Fan Xia¹, Song-Yu Li^1,2, Yin Nian¹, Li-Xin Wei³, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Key Laboratory of Tibetan Medicine Research and Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, China

Received:2021-03-08 Accepted:2021-03-31 Online:2021-07-30 Published:2021-08-24
Contact: Gang Xu
Supported by:
The work was financially supported by the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), State Key Laboratory of Phytochemistry and Plant Resources in West China (P2017-KF02 and P2019-ZZ05), and the Natural Sciences Foundation of Yunnan Province (2019FA003).

Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz

Na Zhang^1,2, Fan Xia¹, Song-Yu Li^1,2, Yin Nian¹, Li-Xin Wei³, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Key Laboratory of Tibetan Medicine Research and Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, China

通讯作者: Gang Xu
基金资助:
The work was financially supported by the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), State Key Laboratory of Phytochemistry and Plant Resources in West China (P2017-KF02 and P2019-ZZ05), and the Natural Sciences Foundation of Yunnan Province (2019FA003).

Abstract

Abstract: Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids (5 and 9-13), seven 7,17-seco-aconitine-type alkaloids (1-4, 6-8), two napelline-type alkaloids (14 and 15) as well as one veatchine-type alkaloid (16), were isolated from the aerial parts of Aconitum fl avum Hand.-Mazz. In which, flavumolines A-D (1-4) were four new ones, and flavumoline E (5) was reported as natural compound for the first time. Their chemical structures were elucidated by the analysis of extensive spectroscopic data. The inhibitory activities of these isolates on Ca_v3.1 low voltage-gated Ca²⁺ channel, NO production in LPS-activated RAW264.7cells, five human tumor cell lines, as well as acetylcholinesterase (AChE) were tested.

Key words: Bioactivity, Aconitum fl avum Hand.-Mazz, Diterpenoid alkaloids

摘要： Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids (5 and 9-13), seven 7,17-seco-aconitine-type alkaloids (1-4, 6-8), two napelline-type alkaloids (14 and 15) as well as one veatchine-type alkaloid (16), were isolated from the aerial parts of Aconitum fl avum Hand.-Mazz. In which, flavumolines A-D (1-4) were four new ones, and flavumoline E (5) was reported as natural compound for the first time. Their chemical structures were elucidated by the analysis of extensive spectroscopic data. The inhibitory activities of these isolates on Ca_v3.1 low voltage-gated Ca²⁺ channel, NO production in LPS-activated RAW264.7cells, five human tumor cell lines, as well as acetylcholinesterase (AChE) were tested.

关键词: Aconitum fl avum Hand.-Mazz, Diterpenoid alkaloids, Bioactivity

Na Zhang, Fan Xia, Song-Yu Li, Yin Nian, Li-Xin Wei, Gang Xu. Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz[J]. Natural Products and Bioprospecting, 2021, 11(4): 421-429.

Na Zhang, Fan Xia, Song-Yu Li, Yin Nian, Li-Xin Wei, Gang Xu. Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz[J]. 应用天然产物, 2021, 11(4): 421-429.

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Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz

Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand. -Mazz

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