Synthesis of L-Ascorbic Acid Lactone Derivatives

doi:10.1007/s13659-014-0022-6

Natural Products and Bioprospecting ›› 2014, Vol. 4 ›› Issue (3): 181-188.DOI: 10.1007/s13659-014-0022-6

• Original article • Previous Articles Next Articles

Synthesis of L-Ascorbic Acid Lactone Derivatives

Li-Dong Shao^1,3, Ya-Nan Wu^1,3, Jun Xu^1,3, Juan He¹, Yu Zhao¹, Li-Yan Peng¹, Yan Li¹, Yu-Rong Yang¹, Cheng-Feng Xia¹, Qin-Shi Zhao²

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. Graduate School of the Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2014-04-13 Revised:2014-04-28 Online:2018-02-11 Published:2014-06-24
Supported by:
This work was financially supported by the National Natural Science Foundation of China(No. U0932602) and the National Basic Research Program of China(973 Program No. 2011CB915503). All authors do not have any financial/commercial conflicts of interest.

Synthesis of L-Ascorbic Acid Lactone Derivatives

Li-Dong Shao^1,3, Ya-Nan Wu^1,3, Jun Xu^1,3, Juan He¹, Yu Zhao¹, Li-Yan Peng¹, Yan Li¹, Yu-Rong Yang¹, Cheng-Feng Xia¹, Qin-Shi Zhao²

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. Graduate School of the Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Cheng-Feng Xia,e-mail:xiachengfeng@mail.kib.ac.cn;Qin-Shi Zhao,e-mail:qinshizhao@mail.kib.ac.cn
基金资助:
This work was financially supported by the National Natural Science Foundation of China(No. U0932602) and the National Basic Research Program of China(973 Program No. 2011CB915503). All authors do not have any financial/commercial conflicts of interest.

Abstract

Abstract: A small focused library which comprised of L-AA lactone derivatives was built with a facile method. This reported method was optimized by modifying the acidity of the solvent. As a result, 12 L-AA lactones were synthesized. Among these lactones, lactones 8-12 were new compounds. The cytotoxicity of these synthetic compounds were investigated.

Key words: L-Ascorbic acid lactone, Cytotoxicity, Focused library

摘要： A small focused library which comprised of L-AA lactone derivatives was built with a facile method. This reported method was optimized by modifying the acidity of the solvent. As a result, 12 L-AA lactones were synthesized. Among these lactones, lactones 8-12 were new compounds. The cytotoxicity of these synthetic compounds were investigated.

关键词: L-Ascorbic acid lactone, Cytotoxicity, Focused library

Li-Dong Shao, Ya-Nan Wu, Jun Xu, Juan He, Yu Zhao, Li-Yan Peng, Yan Li, Yu-Rong Yang, Cheng-Feng Xia, Qin-Shi Zhao. Synthesis of L-Ascorbic Acid Lactone Derivatives[J]. Natural Products and Bioprospecting, 2014, 4(3): 181-188.

Li-Dong Shao, Ya-Nan Wu, Jun Xu, Juan He, Yu Zhao, Li-Yan Peng, Yan Li, Yu-Rong Yang, Cheng-Feng Xia, Qin-Shi Zhao. Synthesis of L-Ascorbic Acid Lactone Derivatives[J]. 应用天然产物, 2014, 4(3): 181-188.

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Synthesis of L-Ascorbic Acid Lactone Derivatives

Synthesis of L-Ascorbic Acid Lactone Derivatives

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