Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

doi:10.1007/s13659-011-0031-7

Natural Products and Bioprospecting ›› 2011, Vol. 1 ›› Issue (3): 116-120.DOI: 10.1007/s13659-011-0031-7

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Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Rui ZHAN^a,b, Xue DU^a, Jia SU^a, Xiao-Nian LI^a, Wei-Guang WANG^a, Cheng-Qin LIANG^a, Jian-Hong YANG^a, Yan LI^a, Jian-Xin PU^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received:2011-11-17 Revised:2011-12-07 Online:2018-02-11 Published:2011-06-24
Supported by:
This work was supported financially by the NSFC-Joint Foundation of Yunnan Province(No. U0832602 to H. D. Sun), the Major State Basic Research Development Program of China(No. 2009CB522300 and 2009CB940900), the Science and Technology Program of Yunnan Province(No. 2008IF010 and 2008CD162), the NSFC(No. 81172939 to J. X. Pu), and the Major Direction Projection Foundation of CAS Intellectual Innovation Project(No. 2010KIBA05 to J. X. Pu).

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Rui ZHAN^a,b, Xue DU^a, Jia SU^a, Xiao-Nian LI^a, Wei-Guang WANG^a, Cheng-Qin LIANG^a, Jian-Hong YANG^a, Yan LI^a, Jian-Xin PU^a, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Jian-Xin PU,E-mail:pujianxin@mail.kib.ac.cn;Han-Dong SUN,E-mail:hdsun@mail.kib.ac.cn
基金资助:
This work was supported financially by the NSFC-Joint Foundation of Yunnan Province(No. U0832602 to H. D. Sun), the Major State Basic Research Development Program of China(No. 2009CB522300 and 2009CB940900), the Science and Technology Program of Yunnan Province(No. 2008IF010 and 2008CD162), the NSFC(No. 81172939 to J. X. Pu), and the Major Direction Projection Foundation of CAS Intellectual Innovation Project(No. 2010KIBA05 to J. X. Pu).

Abstract

Abstract: Three new ent-kauranoids, isorosthornins A-C(1-3), and a new natural product, dihydroponicidin(4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines.

Key words: Isodon rosthornii, ent-kaurane diterpenoid, cytotoxicity

摘要： Three new ent-kauranoids, isorosthornins A-C(1-3), and a new natural product, dihydroponicidin(4), together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines.

关键词: Isodon rosthornii, ent-kaurane diterpenoid, cytotoxicity

Rui ZHAN, Xue DU, Jia SU, Xiao-Nian LI, Wei-Guang WANG, Cheng-Qin LIANG, Jian-Hong YANG, Yan LI, Jian-Xin PU, Han-Dong SUN. Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii[J]. Natural Products and Bioprospecting, 2011, 1(3): 116-120.

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Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii

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