Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

doi:10.1007/s13659-017-0148-4

Natural Products and Bioprospecting ›› 2018, Vol. 8 ›› Issue (1): 47-56.DOI: 10.1007/s13659-017-0148-4

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Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Jin-Tang Cheng, Shi-Tao Chen, Cong Guo, Meng-Jiao Jiao, Wen-Jin Cui, Shu-Hui Wang, Zhe Deng, Chang Chen, Sha Chen, Jun Zhang, An Liu

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2017-10-31 Revised:2017-12-04 Online:2018-02-27 Published:2018-02-24
Contact: An Liu

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Jin-Tang Cheng, Shi-Tao Chen, Cong Guo, Meng-Jiao Jiao, Wen-Jin Cui, Shu-Hui Wang, Zhe Deng, Chang Chen, Sha Chen, Jun Zhang, An Liu

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

基金资助:
We gratefully acknowledge financial support from the independent topics supported by operational expenses for basic research of China Academy of Chinese Medical Sciences (ZXKT15032).

Abstract

Abstract: Six new triterpenoid saponins, aesculusosides A-F (1-6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23-25 exhibited inhibitory activities against MCF-7 with IC₅₀ values ranging from 7.1 to 31.3 μM.

Key words: Aesculus chinensis, Triterpenoid saponins, Chemical structures, Anti-tumor activity

摘要： Six new triterpenoid saponins, aesculusosides A-F (1-6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23-25 exhibited inhibitory activities against MCF-7 with IC₅₀ values ranging from 7.1 to 31.3 μM.

关键词: Aesculus chinensis, Triterpenoid saponins, Chemical structures, Anti-tumor activity

Jin-Tang Cheng, Shi-Tao Chen, Cong Guo, Meng-Jiao Jiao, Wen-Jin Cui, Shu-Hui Wang, Zhe Deng, Chang Chen, Sha Chen, Jun Zhang, An Liu. Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities[J]. Natural Products and Bioprospecting, 2018, 8(1): 47-56.

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Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

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