New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity

doi:10.1007/s13659-015-0055-5

Natural Products and Bioprospecting ›› 2015, Vol. 5 ›› Issue (2): 69-75.DOI: 10.1007/s13659-015-0055-5

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New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity

Yang Wang^1,2, Ling Zhang¹, Fang Wang^1,2, Zheng-Hui Li¹, Ze-Jun Dong¹, Ji-Kai Liu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2015-01-06 Revised:2015-01-31 Online:2018-02-11 Published:2015-04-24
Supported by:
This work was financially supported by the National Science&Technology Pillar Program of China(2012BAD23B0305 and 2013BAI11B02), the National Natural Sciences Foundation of China(U1132607, 21302194).

New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity

Yang Wang^1,2, Ling Zhang¹, Fang Wang^1,2, Zheng-Hui Li¹, Ze-Jun Dong¹, Ji-Kai Liu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China

基金资助:
This work was financially supported by the National Science&Technology Pillar Program of China(2012BAD23B0305 and 2013BAI11B02), the National Natural Sciences Foundation of China(U1132607, 21302194).

Abstract

Abstract: One new cleistanthane-type diterpene named engleromycenolic acid A(1), one new rosane-type diterpene named engleromycenolic acid B(2) and one new natural rosane-type diterpene, engleromycenol(3), along with three known rosanetype diterpenes, rosololactone(4), rosenonolactone(5) and 7-deoxyrosenonolactone(6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their cholesterol ester transfer protein(CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.

Key words: Engleromyces goetzii, Engleromycenolic acid A, Engleromycenolic acid B, Engleromycenol, CETP

摘要： One new cleistanthane-type diterpene named engleromycenolic acid A(1), one new rosane-type diterpene named engleromycenolic acid B(2) and one new natural rosane-type diterpene, engleromycenol(3), along with three known rosanetype diterpenes, rosololactone(4), rosenonolactone(5) and 7-deoxyrosenonolactone(6) were isolated from cultures of the fungus Engleromyces goetzii, where it naturally grows on Alpine bamboo culms. The new compounds were elucidated based on their spectroscopic data. In addition, compounds 1-6 were evaluated for their cholesterol ester transfer protein(CETP) inhibition activity. This paper reports the isolation, structural elucidation, and CETP inhibition activity of these compounds.

关键词: Engleromyces goetzii, Engleromycenolic acid A, Engleromycenolic acid B, Engleromycenol, CETP

Yang Wang, Ling Zhang, Fang Wang, Zheng-Hui Li, Ze-Jun Dong, Ji-Kai Liu. New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity[J]. Natural Products and Bioprospecting, 2015, 5(2): 69-75.

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New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity

New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity

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