Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs

doi:10.1007/s13659-015-0060-8

Abstract

Abstract: This review provides a short account of carbohydrate derivatives of an important natural drug, morphine, along with their comparative efficacies as anesthetic agent. Sugar derivatives are found to have more prospect as anesthetic drug than morphine itself owing to their enhanced bioavailability. Synthetic schemes of these sugar derivatives and information on related patents are also included in this manuscript.

Key words: Morphine, Morphine glycosides, Synthesis, Bioavailability, Anesthetic agents, Related patents

摘要： This review provides a short account of carbohydrate derivatives of an important natural drug, morphine, along with their comparative efficacies as anesthetic agent. Sugar derivatives are found to have more prospect as anesthetic drug than morphine itself owing to their enhanced bioavailability. Synthetic schemes of these sugar derivatives and information on related patents are also included in this manuscript.

关键词: Morphine, Morphine glycosides, Synthesis, Bioavailability, Anesthetic agents, Related patents

Shyamal K. Jash, Dilip Gorai. Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs[J]. Natural Products and Bioprospecting, 2015, 5(3): 111-127.

Shyamal K. Jash, Dilip Gorai. Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs[J]. 应用天然产物, 2015, 5(3): 111-127.

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