Current Perspective in the Discovery of Anti-aging Agents from Natural Products

doi:10.1007/s13659-017-0135-9

Natural Products and Bioprospecting ›› 2017, Vol. 7 ›› Issue (5): 335-404.DOI: 10.1007/s13659-017-0135-9

Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Ai-Jun Ding^1,2, Shan-Qing Zheng^1,2, Xiao-Bing Huang^1,2, Ti-Kun Xing^1,2, Gui-Sheng Wu^1,3, Hua-Ying Sun¹, Shu-Hua Qi⁴, Huai-Rong Luo^1,3,5

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
2. University of Chinese Academy of Sciences, Beijing 100039, China;
3. Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China;
4. Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, Guangdong, China;
5. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, 134 Lanhei Road, Kunming 650201, Yunnan, China

Received:2017-04-16 Revised:2017-05-16 Online:2018-02-06 Published:2017-10-24
Supported by:
This work was supported by the Natural Science Foundation of China (81671405 and 81370453), Natural Science Foundation of Yunnan province (2013FA045 and 2015FB172), and Open Funds of Guangdong Key Laboratory of Marine Materia Medica.

Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Ai-Jun Ding^1,2, Shan-Qing Zheng^1,2, Xiao-Bing Huang^1,2, Ti-Kun Xing^1,2, Gui-Sheng Wu^1,3, Hua-Ying Sun¹, Shu-Hua Qi⁴, Huai-Rong Luo^1,3,5

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
2. University of Chinese Academy of Sciences, Beijing 100039, China;
3. Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China;
4. Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, Guangdong, China;
5. Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, 134 Lanhei Road, Kunming 650201, Yunnan, China

通讯作者: Huai-Rong Luo,e-mail:luohuairong@mail.kib.ac.cn
基金资助:
This work was supported by the Natural Science Foundation of China (81671405 and 81370453), Natural Science Foundation of Yunnan province (2013FA045 and 2015FB172), and Open Funds of Guangdong Key Laboratory of Marine Materia Medica.

Abstract

Abstract: Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing antiaging medicine from natural products.

Key words: Aging, Natural products, Anti-aging, Drug screening

摘要： Aging is a process characterized by accumulating degenerative damages, resulting in the death of an organism ultimately. The main goal of aging research is to develop therapies that delay age-related diseases in human. Since signaling pathways in aging of Caenorhabditis elegans (C. elegans), fruit flies and mice are evolutionarily conserved, compounds extending lifespan of them by intervening pathways of aging may be useful in treating age-related diseases in human. Natural products have special resource advantage and with few side effect. Recently, many compounds or extracts from natural products slowing aging and extending lifespan have been reported. Here we summarized these compounds or extracts and their mechanisms in increasing longevity of C. elegans or other species, and the prospect in developing antiaging medicine from natural products.

关键词: Aging, Natural products, Anti-aging, Drug screening

Ai-Jun Ding, Shan-Qing Zheng, Xiao-Bing Huang, Ti-Kun Xing, Gui-Sheng Wu, Hua-Ying Sun, Shu-Hua Qi, Huai-Rong Luo. Current Perspective in the Discovery of Anti-aging Agents from Natural Products[J]. Natural Products and Bioprospecting, 2017, 7(5): 335-404.

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Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Current Perspective in the Discovery of Anti-aging Agents from Natural Products

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