Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities

doi:10.1007/s13659-019-0207-0

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (3): 223-229.DOI: 10.1007/s13659-019-0207-0

• ORIGINAL ARTICLES • Previous Articles Next Articles

Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities

Xiao-Feng He^1,2,3, Chang-An Geng^1,2, Xiao-Yan Huang^1,2, Yun-Bao Ma^1,2, Xue-Mei Zhang^1,2, Ji-Jun Chen^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China;
3 University of Chinese Academy of Sciences, Beijing 100049, China

Received:2019-03-14 Revised:2019-04-17 Online:2019-06-05 Published:2019-06-24
Contact: Ji-Jun Chen
Supported by:
This work was supported by the CAS Hundred Talents Program, the Youth Innovation Promotion Association of the Chinese Academy of Sciences (CN), and Southeast Asia Biodiversity Research Institute, CAS (2017CASSEABRIQG003).

Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities

Xiao-Feng He^1,2,3, Chang-An Geng^1,2, Xiao-Yan Huang^1,2, Yun-Bao Ma^1,2, Xue-Mei Zhang^1,2, Ji-Jun Chen^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China;
3 University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Ji-Jun Chen
基金资助:
This work was supported by the CAS Hundred Talents Program, the Youth Innovation Promotion Association of the Chinese Academy of Sciences (CN), and Southeast Asia Biodiversity Research Institute, CAS (2017CASSEABRIQG003).

Abstract

Abstract: Mentha haplocalyx (Mentha canadensis) is widely used as a medicinal plant in traditional Chinese medicine, and the extracts of its aerial parts are found to significantly inhibit the activity of α-glucosidase with an IC₅₀ value of 21.0 μg/mL. Bioactivity-guided isolation of the extracts afforded two new compounds (1 and 2), together with 23 known ones (3-25). Their structures were established by extensive spectroscopic analyses (1D and 2D NMR, MS, IR and UV). Compounds 1-17 and 21-25 were evaluated for their α-glucosidase inhibitory activities. Compound 11 was the most active ones with an IC₅₀ values of 83.4 μM. These results verify the α-glucosidase inhibitory activity of M. haplocalyx (M. canadensis) and specify its active compounds for the first time.

Key words: Mentha haplocalyx Briq. (Mentha canadensis L.), Lamiaceae, α-Glucosidase inhibitor

摘要： Mentha haplocalyx (Mentha canadensis) is widely used as a medicinal plant in traditional Chinese medicine, and the extracts of its aerial parts are found to significantly inhibit the activity of α-glucosidase with an IC₅₀ value of 21.0 μg/mL. Bioactivity-guided isolation of the extracts afforded two new compounds (1 and 2), together with 23 known ones (3-25). Their structures were established by extensive spectroscopic analyses (1D and 2D NMR, MS, IR and UV). Compounds 1-17 and 21-25 were evaluated for their α-glucosidase inhibitory activities. Compound 11 was the most active ones with an IC₅₀ values of 83.4 μM. These results verify the α-glucosidase inhibitory activity of M. haplocalyx (M. canadensis) and specify its active compounds for the first time.

关键词: Mentha haplocalyx Briq. (Mentha canadensis L.), Lamiaceae, α-Glucosidase inhibitor

Xiao-Feng He, Chang-An Geng, Xiao-Yan Huang, Yun-Bao Ma, Xue-Mei Zhang, Ji-Jun Chen. Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities[J]. Natural Products and Bioprospecting, 2019, 9(3): 223-229.

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Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities

Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities

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