Diverse Polyphenols from Hypericum faberi

doi:10.1007/s13659-019-0206-1

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (3): 215-221.DOI: 10.1007/s13659-019-0206-1

• ORIGINAL ARTICLES • Previous Articles Next Articles

Diverse Polyphenols from Hypericum faberi

Xin-Wen Zhang^1,2, Yan-Song Ye^1,2, Fan Xia¹, Xing-Wei Yang¹, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2019-04-01 Revised:2019-04-11 Online:2019-06-05 Published:2019-06-24
Contact: Xin-Wen Zhang
Supported by:
The work was financially supported by the foundations from Kunming Institute of Botany (KIB2017001), Southeast Asia Biodiversity Research Institute (2017CASSEABRIQG003), CAS, and Yunnan Key Laboratory of Natural Medicinal Chemistry (S2017-ZZ11 and 2015-ZZ07).

Diverse Polyphenols from Hypericum faberi

Xin-Wen Zhang^1,2, Yan-Song Ye^1,2, Fan Xia¹, Xing-Wei Yang¹, Gang Xu¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

通讯作者: Xin-Wen Zhang
基金资助:
The work was financially supported by the foundations from Kunming Institute of Botany (KIB2017001), Southeast Asia Biodiversity Research Institute (2017CASSEABRIQG003), CAS, and Yunnan Key Laboratory of Natural Medicinal Chemistry (S2017-ZZ11 and 2015-ZZ07).

Abstract

Abstract: Six new polyphenols with different isoprenylated xanthones, isoprenylated acylphloroglucinols, and chromone architectures, hyperfaberols A-F (1-6), were isolated from the whole plants of Hypericum faberi along with seven other related known compounds. In which hyperfaberols A/B (1/2) and 12-13 were isoprenylated xanthones, hyperfaberols C-E (3-5) and 8-11 were seven isoprenylated acylphloroglucinol derivatives, while 6-7 were two chromones. Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data. Compounds 1 and 11 showed cytotoxities against the human esophageal cancer cell line (ECA-109) and the pancreatic tumor cell line (PANC-1) in vitro, respectively.

Key words: Hypericum faberi, Isoprenylated xanthone, Isoprenylated acylphloroglucinol, Chromone, Cytotoxicitiy

摘要： Six new polyphenols with different isoprenylated xanthones, isoprenylated acylphloroglucinols, and chromone architectures, hyperfaberols A-F (1-6), were isolated from the whole plants of Hypericum faberi along with seven other related known compounds. In which hyperfaberols A/B (1/2) and 12-13 were isoprenylated xanthones, hyperfaberols C-E (3-5) and 8-11 were seven isoprenylated acylphloroglucinol derivatives, while 6-7 were two chromones. Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data. Compounds 1 and 11 showed cytotoxities against the human esophageal cancer cell line (ECA-109) and the pancreatic tumor cell line (PANC-1) in vitro, respectively.

关键词: Hypericum faberi, Isoprenylated xanthone, Isoprenylated acylphloroglucinol, Chromone, Cytotoxicitiy

Xin-Wen Zhang, Yan-Song Ye, Fan Xia, Xing-Wei Yang, Gang Xu. Diverse Polyphenols from Hypericum faberi[J]. Natural Products and Bioprospecting, 2019, 9(3): 215-221.

Xin-Wen Zhang, Yan-Song Ye, Fan Xia, Xing-Wei Yang, Gang Xu. Diverse Polyphenols from Hypericum faberi[J]. 应用天然产物, 2019, 9(3): 215-221.

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Diverse Polyphenols from Hypericum faberi

Diverse Polyphenols from Hypericum faberi

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