Synthesis and Cytotoxicities of Royleanone Derivatives

doi:10.1007/s13659-018-0173-y

Natural Products and Bioprospecting ›› 2018, Vol. 8 ›› Issue (6): 453-456.DOI: 10.1007/s13659-018-0173-y

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Synthesis and Cytotoxicities of Royleanone Derivatives

Cheng-Ji Li^1,3, Fan Xia^1,3, Rong Wu², Hong-Sheng Tan², Hong-Xi Xu², Gang Xu¹, Hong-Bo Qin¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2018-05-13 Revised:2018-06-08 Online:2018-11-21 Published:2018-12-24
Contact: Hong-Xi Xu, Gang Xu, Hong-Bo Qin
Supported by:
The work was financially supported by the foundations from NSFC (81373291) to Dr. G. Xu, NSFC (21372229) to Dr. H. B. Qin, and from Foundation of Kunming Institute of Botany (KIB2017007) to Dr. G. Xu.

Synthesis and Cytotoxicities of Royleanone Derivatives

Cheng-Ji Li^1,3, Fan Xia^1,3, Rong Wu², Hong-Sheng Tan², Hong-Xi Xu², Gang Xu¹, Hong-Bo Qin¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

通讯作者: Hong-Xi Xu, Gang Xu, Hong-Bo Qin
基金资助:
The work was financially supported by the foundations from NSFC (81373291) to Dr. G. Xu, NSFC (21372229) to Dr. H. B. Qin, and from Foundation of Kunming Institute of Botany (KIB2017007) to Dr. G. Xu.

Abstract

Abstract: Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.

Key words: Royleanones, Cytotoxicity, para benzoquinone

摘要： Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.

关键词: Royleanones, Cytotoxicity, para benzoquinone

Cheng-Ji Li, Fan Xia, Rong Wu, Hong-Sheng Tan, Hong-Xi Xu, Gang Xu, Hong-Bo Qin. Synthesis and Cytotoxicities of Royleanone Derivatives[J]. Natural Products and Bioprospecting, 2018, 8(6): 453-456.

Cheng-Ji Li, Fan Xia, Rong Wu, Hong-Sheng Tan, Hong-Xi Xu, Gang Xu, Hong-Bo Qin. Synthesis and Cytotoxicities of Royleanone Derivatives[J]. 应用天然产物, 2018, 8(6): 453-456.

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Synthesis and Cytotoxicities of Royleanone Derivatives

Synthesis and Cytotoxicities of Royleanone Derivatives

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