Application of Metabolomics in the Study of Natural Products

doi:10.1007/s13659-018-0175-9

Natural Products and Bioprospecting ›› 2018, Vol. 8 ›› Issue (4): 321-334.DOI: 10.1007/s13659-018-0175-9

• ORIGINAL ARTICLES • Previous Articles

Application of Metabolomics in the Study of Natural Products

Qi Zhao^1,2, Jia-Le Zhang³, Fei Li¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Lanzhou University of Technology, Lanzhou 730050, People's Republic of China

Received:2018-05-01 Revised:2018-06-25 Online:2018-08-28 Published:2018-08-24
Contact: Fei Li,lifeib@mail.kib.ac.cn
Supported by:
This work was supported by the Thousand Young Talents Program of China, the National Key Research and Development Program of China (2017YFC1700906, 2017YFC0906903), CAS "Light of West China" Program (Y72E8211W1), Kunming Institute of Botany (Y76E1211K1, Y4662211K1), and State Key Laboratory of Phytochemistry and Plant Resources in West China (52Y67A9211Z1).

Application of Metabolomics in the Study of Natural Products

Qi Zhao^1,2, Jia-Le Zhang³, Fei Li¹

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Lanzhou University of Technology, Lanzhou 730050, People's Republic of China

通讯作者: Fei Li,lifeib@mail.kib.ac.cn
基金资助:
This work was supported by the Thousand Young Talents Program of China, the National Key Research and Development Program of China (2017YFC1700906, 2017YFC0906903), CAS "Light of West China" Program (Y72E8211W1), Kunming Institute of Botany (Y76E1211K1, Y4662211K1), and State Key Laboratory of Phytochemistry and Plant Resources in West China (52Y67A9211Z1).

Abstract

Abstract: LC-MS-based metabolomics could have a major impact in the study of natural products, especially in its metabolism, toxicity and activity. This review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products, and the understanding of their effects on various diseases. Metabolomics has been employed to study the in vitro and in vivo metabolism of natural compounds, such as osthole, dehydrodiisoeugenol, and myrislignan. The pharmacological effects of natural compounds and extracts were determined using metabolomics technology combined with diseases models in animal, including osthole and nutmeg extracts. It has been demonstrated that metabolomics is a powerful technology for the investigation of xenobiotics-induced toxicity. The metabolism of triptolide and its hepatotoxicity were discussed. LC-MS-based metabolomics has a great potential in the druggability of natural products. The application of metabolomics should be broadened in the field of natural products in the future.

Key words: Metabolomics, Natural products, Metabolism, Bioactivity, Toxicity

摘要： LC-MS-based metabolomics could have a major impact in the study of natural products, especially in its metabolism, toxicity and activity. This review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products, and the understanding of their effects on various diseases. Metabolomics has been employed to study the in vitro and in vivo metabolism of natural compounds, such as osthole, dehydrodiisoeugenol, and myrislignan. The pharmacological effects of natural compounds and extracts were determined using metabolomics technology combined with diseases models in animal, including osthole and nutmeg extracts. It has been demonstrated that metabolomics is a powerful technology for the investigation of xenobiotics-induced toxicity. The metabolism of triptolide and its hepatotoxicity were discussed. LC-MS-based metabolomics has a great potential in the druggability of natural products. The application of metabolomics should be broadened in the field of natural products in the future.

关键词: Metabolomics, Natural products, Metabolism, Bioactivity, Toxicity

Qi Zhao, Jia-Le Zhang, Fei Li. Application of Metabolomics in the Study of Natural Products[J]. Natural Products and Bioprospecting, 2018, 8(4): 321-334.

Qi Zhao, Jia-Le Zhang, Fei Li. Application of Metabolomics in the Study of Natural Products[J]. 应用天然产物, 2018, 8(4): 321-334.

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Application of Metabolomics in the Study of Natural Products

Application of Metabolomics in the Study of Natural Products

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