Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside

doi:10.1007/s13659-025-00550-7

Natural Products and Bioprospecting ›› 2025, Vol. 15 ›› Issue (6): 69-69.DOI: 10.1007/s13659-025-00550-7

Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside

Fatemeh Najafi¹, Negar Farrokhzad², Amirhossein Ghaemi³, Dorsa Azizi Khezri⁴, Mohammadali Hajiabbas⁵, Amirhossein Khanizadeh³, Nasim Kaveh Farsani⁶, Mahsa Khoramipour⁷, Niloofar Fatemipayam⁸, Elham Seyyedi Zadeh³, Arash Goodarzi⁹, Behnoosh Khodadadi¹⁰, Fatemeh Moradbeygi^11,12, Ahmad Reza Farmani⁹, Mohammad Tavakkoli Yaraki¹³, Martin Federico Desimone^14,15

1. Department of Chemical Engineering, Pennsylvania State University, University Park, PA, 16802-1503, USA;
2. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK;
3. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran;
4. School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran;
5. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran;
6. Department of Chemical Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran;
7. Department of Biology, Faculty of Sciences, Arak University, Arak, Iran;
8. Chemical Engineering Department, Oklahoma State University, Stillwater, OK, USA;
9. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, 74615-168, Iran;
10. Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Tehran, Iran;
11. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran;
12. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran;
13. School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, 2109, Australia;
14. Universidade Federal Do Rio Grande (FURG), Instituto de Ciências Biológicas (ICB), Programa de Pós-Graduação Em Ciências Fisiológicas (PPGCF), Rio Grande, RS, Brazil;
15. Universidad de Buenos Aires (UBA), CONICET, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

Received:2025-04-04 Online:2026-01-12
Contact: Ahmad Reza Farmani Email:E-mail:ahmadrezafarmani66@gmail.com
Supported by:
Authors would like to thank Fasa University of Medical Sciences, Fasa, Iran for the project number 403289.

Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside

1. Department of Chemical Engineering, Pennsylvania State University, University Park, PA, 16802-1503, USA;
2. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK;
3. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran;
4. School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran;
5. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran;
6. Department of Chemical Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran;
7. Department of Biology, Faculty of Sciences, Arak University, Arak, Iran;
8. Chemical Engineering Department, Oklahoma State University, Stillwater, OK, USA;
9. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, 74615-168, Iran;
10. Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Tehran, Iran;
11. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran;
12. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran;
13. School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, 2109, Australia;
14. Universidade Federal Do Rio Grande (FURG), Instituto de Ciências Biológicas (ICB), Programa de Pós-Graduação Em Ciências Fisiológicas (PPGCF), Rio Grande, RS, Brazil;
15. Universidad de Buenos Aires (UBA), CONICET, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

通讯作者: Ahmad Reza Farmani Email:E-mail:ahmadrezafarmani66@gmail.com
作者简介:Mohammad Tavakkoli Yaraki Email:E-mail:mty206@yahoo.com;Martin Federico Desimone Email:E-mail:desimone@ffyb.uba.ar
基金资助:
Authors would like to thank Fasa University of Medical Sciences, Fasa, Iran for the project number 403289.

Abstract

Abstract: The resurgence of interest in traditional herbal remedies stems from an increasing appreciation for their complex phytochemical profiles and potential for synergistic therapeutic effects. However, the therapeutic potential of plant extracts is often limited by poor absorption and potential toxicity related to conventional delivery methods. This review explores the application of nanocarrier-mediated delivery systems, such as nanoparticles (NPs), liposomes, and nanoemulsions, to address these challenges. These biocompatible carriers offer enhanced stability and targeted delivery of herbal compounds, improving their efficacy and reducing unwanted side effects. By enabling precise distribution, nanotechnology optimizes the potency of herbal medicine across diverse applications, including regenerative medicine, wound healing, anticancer, and infection treatment. This review provides a systematic description of successful applications of nano-delivery technologies, nanoparticles, liposomes, nanoemulsions, and hybrid carriers, for the targeted delivery of some well-characterized herbal bioactives (curcumin, allicin, berberine, resveratrol etc.) and the enhanced therapeutic performance of herbal bioactives across a variety of preclinical models.

Key words: Nano-delivery systems, Herbal compounds, Wound healing, Tissue engineering, Bioavailability

摘要： The resurgence of interest in traditional herbal remedies stems from an increasing appreciation for their complex phytochemical profiles and potential for synergistic therapeutic effects. However, the therapeutic potential of plant extracts is often limited by poor absorption and potential toxicity related to conventional delivery methods. This review explores the application of nanocarrier-mediated delivery systems, such as nanoparticles (NPs), liposomes, and nanoemulsions, to address these challenges. These biocompatible carriers offer enhanced stability and targeted delivery of herbal compounds, improving their efficacy and reducing unwanted side effects. By enabling precise distribution, nanotechnology optimizes the potency of herbal medicine across diverse applications, including regenerative medicine, wound healing, anticancer, and infection treatment. This review provides a systematic description of successful applications of nano-delivery technologies, nanoparticles, liposomes, nanoemulsions, and hybrid carriers, for the targeted delivery of some well-characterized herbal bioactives (curcumin, allicin, berberine, resveratrol etc.) and the enhanced therapeutic performance of herbal bioactives across a variety of preclinical models.

关键词: Nano-delivery systems, Herbal compounds, Wound healing, Tissue engineering, Bioavailability

Fatemeh Najafi, Negar Farrokhzad, Amirhossein Ghaemi, Dorsa Azizi Khezri, Mohammadali Hajiabbas, Amirhossein Khanizadeh, Nasim Kaveh Farsani, Mahsa Khoramipour, Niloofar Fatemipayam, Elham Seyyedi Zadeh, Arash Goodarzi, Behnoosh Khodadadi, Fatemeh Moradbeygi, Ahmad Reza Farmani, Mohammad Tavakkoli Yaraki, Martin Federico Desimone. Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside[J]. Natural Products and Bioprospecting, 2025, 15(6): 69-69.

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Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside

Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside

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[2]	Shyamal K. Jash, Dilip Gorai. Sugar Derivatives of Morphine: A New Window for the Development of Potent Anesthetic Drugs [J]. Natural Products and Bioprospecting, 2015, 5(3): 111-127.