The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient

doi:10.1007/s13659-024-00431-5

Abstract

Abstract: Reacting to the challenges presented by the evolving nexus of environmental change, defossilization, and diversified natural product bioprospecting is vitally important for advancing global healthcare and placing patient benefit as the most important consideration. This overview emphasizes the importance of natural and synthetic medicines security and proposes areas for global research action to enhance the quality, safety, and effectiveness of sustainable natural medicines. Following a discussion of some contemporary factors influencing natural products, a rethinking of the paradigms in natural products research is presented in the interwoven contexts of the Fourth and Fifth Industrial Revolutions and based on the optimization of the valuable assets of Earth. Following COP28, bioprospecting is necessary to seek new classes of bioactive metabolites and enzymes for chemoenzymatic synthesis. Focus is placed on those performance and practice modifications which, in a sustainable manner, establish the patient, and the maintenance of their prophylactic and treatment needs, as the priority. Forty initiatives for natural products in healthcare are offered for the patient and the practitioner promoting global action to address issues of sustainability, environmental change, defossilization, quality control, product consistency, and neglected diseases to assure that quality natural medicinal agents will be accessible for future generations.

Key words: Medicines security, Traditional medicine, Optimizing resources, Sustainability, Defossilization, Action initiatives

摘要： Reacting to the challenges presented by the evolving nexus of environmental change, defossilization, and diversified natural product bioprospecting is vitally important for advancing global healthcare and placing patient benefit as the most important consideration. This overview emphasizes the importance of natural and synthetic medicines security and proposes areas for global research action to enhance the quality, safety, and effectiveness of sustainable natural medicines. Following a discussion of some contemporary factors influencing natural products, a rethinking of the paradigms in natural products research is presented in the interwoven contexts of the Fourth and Fifth Industrial Revolutions and based on the optimization of the valuable assets of Earth. Following COP28, bioprospecting is necessary to seek new classes of bioactive metabolites and enzymes for chemoenzymatic synthesis. Focus is placed on those performance and practice modifications which, in a sustainable manner, establish the patient, and the maintenance of their prophylactic and treatment needs, as the priority. Forty initiatives for natural products in healthcare are offered for the patient and the practitioner promoting global action to address issues of sustainability, environmental change, defossilization, quality control, product consistency, and neglected diseases to assure that quality natural medicinal agents will be accessible for future generations.

关键词: Medicines security, Traditional medicine, Optimizing resources, Sustainability, Defossilization, Action initiatives

Geoffrey A. Cordell. The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient[J]. Natural Products and Bioprospecting, 2024, 14(2): 1-1.

Geoffrey A. Cordell. The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient[J]. 应用天然产物, 2024, 14(2): 1-1.

References

[1] Cordell GA. Not for us-but for our descendants. Thai J Pharm Sci. 1992;16:1-3.
[2] Clark JL. Thus spoke Chief Seattle: the story of an undocumented speech. Prolog Mag. 1985;1985(18):58-65.
[3] Maddocks F. Hildegard of Bingen: the woman of her age. New York: Doubleday; 2001.
[4] Sivaraska S. The wisdom of sustainability. Buddhist economics for the 21st century. Kihei: Koa Books; 2009.
[5] Lovelock JE. Gaia. A new look at life on Earth. Oxford: Oxford University Press; 1979.
[6] Tyrrell T. On Gaia: a critical investigation of the relationship between life and Earth. Princeton: Princeton University Press; 2013.
[7] Anonymous. 1854. Chief Seattle’s letter to all. Available at http://www.csun.edu/~vcpsy00h/seattle.htm. Accessed 28 December 2023.
[8] Cordell GA, Colvard MD. Natural products and traditional medicine - turning on a paradigm. J Nat Prod. 2012;75:514-25.
[9] The Nature Conservancy. The latest IPCC report: what is it and why does it matter? 2023. https://www.nature.org/en-us/what-we-do/our-insights/perspectives/ipcc-report-climate-change/. Accessed 28 December 2023.
[10] Wilson EO. Half Earth Our planet’s fight for life. New York: Liveright Publishing Co.; 2016.
[11] Van der Linden S, Leiserowitz A, Rosenthal S, Maibach E. Inoculating the public against misinformation about climate change. Global Chall. 2017;1:1600008.
[12] Ripple WJ, Wolf C, Newsome TM, Galetti M, Alamgir M, Crist E, 15,364 scientist signatories from 184 countries, et al. World scientists? warning to humanity: a second notice. Bioscience. 2017;2017(67):1026-8.
[13] Crutzen PJ, Stoermer EF. The anthropocene. Glob Change Newslett. 2000;41:17-8.
[14] Premanandh J. Factors affecting food security and contribution of modern technologies in food sustainability. J Sci Food Agric. 2011;91:2707-14.
[15] Buddle BM, Denis M, Attwood GT, Altermann E, Janssen PH, Ronimus RS, et al. Strategies to reduce methane emissions from farmed ruminants grazing on pasture. Vet J. 2011;188:11-7.
[16] Chynoweth DP, Owens JM, Legrand R. Renewable methane from anaerobic digestion of biomass. Renew Energy. 2001;22:1-8.
[17] Supit I, Van Diepen CA, De Wit AJW, Wolf J, Kabat P, Baruth B, et al. Assessing climate change effects on European crop yields using the Crop Growth Monitoring System and a weather generator. Agric Forest Meteorol. 2012;164:96-111.
[18] Coronese M, Lamperti F, Keller K, Chiaromonte F, Roventini A. Evidence for sharp increase in the economic damages of extreme natural disasters. Proc Natl Acad Sci. 2019;116:21450-5.
[19] Ripple WJ, Wolf C, Gregg JW, Levin K, Rockström J, Newsome TM, et al. World scientists’ warning of a climate emergency 2022. Bioscience. 2022;72:1149-55.
[20] Hallegatte S, Green C, Nicholls RJ, Corfee-Morlot J. Future flood losses in major coastal cities. Nat Clim Change. 2013;3:802-6.
[21] Kulp SA, Strauss BH. New elevation data triple estimates of global vulnerability to sea-level rise and coastal flooding. Nat Commun. 2019;10:1-12.
[22] Tapu IF. Finding fonua: disappearing Pacific Island nations, sea level rise, and cultural rights. Ariz Law Rev. 2020;62:785.
[23] McCubbin S, Smit B, Pearce T. Where does climate fit? Vulnerability to climate change in the context of multiple stressors in Funafuti, Tuvalu. Glob Environ Change. 2015;30:43-55.
[24] Cauchi JP, Correa-Velez I, Bambrick H. Climate change, food security and health in Kiribati: a narrative review of the literature. Glob Health Action. 2019;12:1603683.
[25] Weatherill CK. Sinking paradise? Climate change vulnerability and Pacific Island extinction narratives. Geoforum. 2023;145: 103566.
[26] Sayers P, Moss C, Carr S, Garcia AP. Responding to climate change around England’s coast: the scale of the transformational challenge. Ocean Coast Manage. 2022;225: 106187.
[27] Clark JA, Farrell WE, Peltier WR. Global changes in postglacial sea level: a numerical calculation. Quat Res. 1978;9:265-87.
[28] Gornitz V. Global coastal hazards from future sea level rise. Palaeogeogr Palaeocl Palaeoecol. 1991;89:379-98.
[29] Nicholls RJ, Cazenave A. Sea-level rise and its impact on coastal zones. Science. 2010;328:1517-20.
[30] Schuerch M, Spencer T, Temmerman S, Kirwan ML, Wolff C, Lincke D, et al. Future response of global coastal wetlands to sea-level rise. Nature. 2018;561:231-4.
[31] Burnham JP. Climate change and antibiotic resistance: a deadly combination. Ther Adv Infect Dis. 2021;8:1-7.
[32] Pant P, Pandey S, Dall’Acqua S. The influence of environmental conditions on secondary metabolites in medicinal plants: a literature review. Chem Biodivers. 2021;18: e2100345.
[33] Haider MZ, Ashraf MA, Rasheed R, Hussain I, Riaz M, Qureshi FF, et al. Impact of salinity stress on medicinal plants. In: Husen A, Iqbal M, editors, et al., Medicinal plants: their response to abiotic stress. Singapore: Springer Nature; 2023. p. 199-239.
[34] Sengupta S, Thuy TL. Rice gets reimagined, from the Mississippi to the Mekong. NY Times, May 23, 2023. https://www.nytimes.com/interactive/2023/05/20/climate/rice-farming-climate-change.html?action=click&module=Well&pgtype=Homepage&section=Climate%20and%20Environment. Accessed 28 Dec 2023.
[35] Union of Concerned Scientists. World Scientists? Warning to Humanity. Cambridge, UK, Union of Concerned Scientists, 1992. https://www.ucsusa.org/about/1992-world-scientists.html#.XD5D4ml7ncs. Accessed 28 Dec 2023.
[36] Applequist WL, Brinckmann JA, Cunningham AB, Hart RE, Heinrich M, Katerere DR, et al. Scientists? warning on climate change and medicinal plants. Planta Med. 2020;86:10-8.
[37] United Nations Framework Convention on Climate Change. The Paris Agreement. What is the Paris Agreement? 2023. https://unfccc.int/process-and-meetings/the-paris-agreement. Accessed 28 Dec 2023.
[38] Liu PR, Raftery AE. Country-based rate of emissions reductions should increase by 80% beyond nationally determined contributions to meet the 2℃ target. Commun Earth Environ. 2021;2:29.
[39] United Nations Environment Programme Copenhagen Climate Centre. World is off track to meet Paris Agreement climate targets. September 16 2021. https://unepccc.org/world-is-off-track-to-meet-paris-agreement-climate-targets/. Accessed 28 Dec 2023.
[40] Kühne K, Bartsch N, Tate RD, Higson J, Habet A. “Carbon bombs”: mapping key fossil fuel projects. Energy Policy. 2022;166: 112950.
[41] Intergovernmental Panel on Climate Change. Climate change: a threat to human well-being and health of the planet. Taking action now can secure our future. February 2022. https://www.ipcc.ch/2022/02/28/pr-wgii-ar6/. Accessed 28 Dec 2023.
[42] Copernicus Climate Change Service. Record warm November consolidates 2023 as the warmest year. https://climate.copernicus.eu/ Accessed 23 Dec 2023.
[43] van Kleunen M, Xu X, Yang Q, Maurel N, Zhang Z, Dawson W, et al. Economic use of plants is key to their naturalization success. Nat Commun. 2020;11:3201.
[44] Heywood VH, Stuart SN. Species extinctions in tropical forests. In: Whitmore TC, Sayer JA, editors. Tropical deforestation and species extinction. London: Chapman & Hall; 1992. p. 91-117.
[45] Antonelli A. and collaborators. State of the World’s Plants and Fungi 2020. Richmond: Royal Botanic Gardens Kew. https://doi.org/10.34885/172.
[46] Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). 2022. What is CITES? https://cites.org/eng/disc/what.php. Accessed on 28 Dec 2023.
[47] Cordell GA, Daley S-K. Cyberecoethnopharmacolomics-an integrated approach to traditional medicine quality control. In: Mukherjee PK, editor. Evidence-based validation of herbal medicine. 2nd ed. New York: Elsevier; 2022. p. 629-49.
[48] Cordell GA. Sixty challenges - a 2030 perspective on natural products and medicines security. Nat Prod Commun. 2017;12:1371-9.
[49] Cordell GA, Colvard MD. Natural products in a world out-of-balance. ARKIVOC. 2006;2007:97-115.
[50] Gupta J, Hurley F, Grobicki A, Keating T, Stoett P, Baker E, et al. Communicating the health of the planet and its links to human health. Lancet Planet Health. 2019;3:e204-6.
[51] Sparviero S, Ragnedda M. Towards digital sustainability: the long journey to the sustainable development goals 2030. Digit Policy Reg Govern. 2021;23:216-28.
[52] Vollset SE, Goren E, Yuan C-W, Cao J, Smith AE, Hsiao T, et al. Fertility, mortality, migration, and population scenarios for 195 countries and territories from 2017 to 2100: a forecasting analysis for the Global Burden of Disease Study. Lancet. 2020;396:1285-306.
[53] Anonymous. Countries with declining population. 2023. https://worldpopulationreview.com/country-rankings/countries-with-declining-population. Accessed 28 December 2023.
[54] Anonymous. Pope Francis warns pets must not replace children in Italy. May 12, 2023. https://www.bbc.com/news/world-europe-65572153. Accessed 28 Dec 2023.
[55] Clar RL, Ogawa N, Kondo M, Matsukura R. Population decline, labor force stability, and the future of the Japanese economy. Eur J Popul. 2010;26:207-27.
[56] Rees WE. End game: the economy as eco-catastrophe and what needs to change. Real-world Econ Rev. 2019;87:132-48.
[57] Zimmerman JB, Anastas PT, Erythropel HC, Leitner W. Designing for a green chemistry future. Science. 2020;367:397-400.
[58] Cordell GA. Phytochemistry and traditional medicine - the revolution continues. Phytochem Lett. 2014;10:28-40.
[59] Cordell GA. Ecopharmacognosy-the responsibilities of natural product research to sustainability. Phytochem Lett. 2015;11:332-46.
[60] Cordell GA. Ecopharmacognosy. In: Heinrich M, Jäger A, editors. Ethnopharmacology - a reader. Chichester: Wiley Science Publishers; 2015. p. 53-62.
[61] Cordell GA. Ecopharmacognosy - why natural products matter - now and for the future. Thai Bull Pharm Sci. 2018;13:1-9.
[62] Cordell GA. Cyberecoethnopharmacolomics. J Ethnopharmacol. 2019;244: 112134.
[63] Gargalo CL, Rapazzo J, Carvalho A, Gernaey KV. Optimal conversion of organic wastes to value-added products: toward a sustainable integrated biorefinery in Denmark. Front Chem Eng. 2022;4: 837105.
[64] Wackernagel M, Schulz NB, Deumling D, Callejas Linares A, Jenkins M, Kapos V, et al. Tracking the ecological overshoot of the human economy. Proc Natl Acad Sci. 2002;99:9266-71.
[65] Regenesis MG. Feeding the world without devouring the planet. London: Penguin Books; 2022.
[66] Daley S-K, Cordell GA. Natural products, the fourth industrial revolution and the quintuple helix. Nat Prod Commun. 2021;16:1-31.
[67] Chan AYL, Chan VKY, Olsson S, Fan M, Jit M, Gong M, et al. Access and unmet needs of orphan drugs in 194 countries and 6 areas: a global policy review with content analysis. Value Health. 2020;23:1580-91.
[68] Gourd E. Cancer care critically affected by USA drug shortages. Lancet Oncol. 2023;24:727.
[69] Howard J. More than 90% of large cancer centers report shortages of life-saving chemo drugs in new survey. 7 June 2023. https://www.cnn.com/2023/06/07/health/cancer-center-chemo-drugs/index.html. Accessed 28 Dec 2023.
[70] Jewett C. Rising rate of drug shortages framed as a national security threat. NY Times. 2023;March 22. https://www.nytimes.com/2023/03/22/health/drug-shortages.html?searchResultPosition=3. Accessed 6 Dec 2023.
[71] Jewett C. Drug shortages near an all-time high, leading to rationing. NY Times. 2023;May 17. https://www.nytimes.com/2023/05/17/health/drug-shortages-cancer.html?searchResultPosition=4. Accessed 6 Dec 2023.
[72] Cohen R, Pettoello-Mantovani M, Giardino I, Carrasco-Sanz A, Somekh E, Levy C. The shortage of amoxicillin: an escalating public health crisis in pediatrics faced by several Western countries. J Pediatr. 2023;257:13321.
[73] Tucker E. Why are stuck in a never-ending cycle of drug shortages? NY Times, Dec. 6, 2023 https://www.nytimes.com/2023/12/06/opinion/drug-shortages-pharmaceuticals.html?searchResultPosition=1. Accessed 6 Dec 2023.
[74] Pray WS. Ethical, scientific, and educational concerns with unproven medications. Am J Pharm Ed. 2006;70:141.
[75] Cordell GA. Alice, benzene, and coffee: the ABC’s of ecopharmacognosy. Nat Prod Commun. 2015;10:2195-202.
[76] Bessell TL, Anderson JN, Silagy CA, Sansom LN, Hiller JE. Surfing, self-medicating and safety: buying non-prescription and complementary medicines via the internet. BMJ Qual Saf. 2003;12:88-92.
[77] Dylst P, Vulto A, Simoens S. Demand-side policies to encourage the use of generic medicines: an overview. Exp Rev Pharm Out Res. 2013;13:59-72.
[78] World Population Clock. https://www.worldometers.info/world-population/. Accessed 28 Dec 2023.
[79] Anonymous. Life expectancy (from birth) in the United States, from 1860 to 2020. https://www.statista.com/statistics/1040079/life-expectancy-united-states-all-time/. Accessed 28 Dec 2023.
[80] American Geriatrics Society Beers Criteria^® Update Expert Panel. American Geriatrics Society 2019 updated AGS Beers Criteria^® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2019;2019(67):674-94.
[81] International Health Conference. Constitution of the World Health Organization, 1946. Bull World Health Org. 2002;80:983-98.
[82] World Health Organization. WHO Health Statistics 2022. https://www.who.int/news/item/20-05-2022-world-health-statistics-2022. Accessed 28 Dec 2023.
[83] United Nations Sustainable Development Goals. https://sdgs.un.org/goals. Accessed 28 Dec 2023.
[84] Newman DJ, Cragg GM. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod. 2020;83:770-803.
[85] Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, et al. Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv. 2015;33:1582-614.
[86] Cordell GA. Plant medicines key to global health. Chem Eng News. 2011. https://doi.org/10.1021/cen061611145657.
[87] Daley S-K, Cordell GA. Alkaloids in contemporary drug discovery to meet global disease needs. Molecules. 2021;26:03800.
[88] Yuan R, Hou Y, Sun W, Yu J, Liu X, Niu Y, et al. Natural products to prevent drug resistance in cancer chemotherapy: a review. Ann NY Acad Sci. 2017;1401:19-27.
[89] Goupil LS, McKerrow JH. Introduction: drug discovery and development for neglected diseases. Chem Rev. 2014;114:11131-7.
[90] Cheuka PM, Mayoka G, Mutai P, Chibale K. The role of natural products in drug discovery and development against neglected tropical diseases. Molecules. 2016;22:58.
[91] Guo D-A, Wu W-Y, Ye M, Liu X, Cordell GA. A holistic approach to the quality control of traditional Chinese medicines. Science. 2015;347:S29-31.
[92] Molokhia M, Majeed A. Current and future perspectives on the management of polypharmacy. BMC Fam Prac. 2017;18:1-9.
[93] Tannoury M, Attieh Z. The influence of emerging markets on the pharmaceutical industry. Curr Therap Res. 2017;86:19-22.
[94] Frenk J, Chen L. Overcoming gaps to advance global health equity: a symposium on new directions for research. Health Res Policy Syst. 2011;9:1-4.
[95] Kang S-Y, Bai G, DiStefano MJ, Socal MP, Yehia F, Anderson GF. Comparative approaches to drug pricing. Ann Rev Publ Health. 2020;41:499-512.
[96] Cordell GA. Sustainable drugs and global health care. Quim Nova. 2009;32:1356-64.
[97] Hwenda L. The business case for vaccine and drug manufacturing in middle-income countries. Lancet Glob Health. 2022;10:e944-5.
[98] United States Food and Drug Administration. Drug shortages. 2023 https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages. Accessed 28 Dec 2023.
[99] Yegros A, Tijssen R, Abad-Garcia M-F, Ràfols I. Drug research priorities at odds with global disease toll. Nat Index 2018;March 16.
[100] World Health Organization. Access to medicines: making market forces serve the poor. 2017. https://www.who.int/publications/m/item/access-to-medicines-making-market-forces-serve-the-poor. Accessed 28 Dec 2023.
[101] Newton PN, Bond KC, 53 signatories. COVID-19 and risks to the supply and quality of tests, drugs, and vaccines. Lancet Glob Health. 2020;8:e754-5.
[102] Centers for Disease Control and Prevention. 2023. Neglected tropical diseases. https://www.cdc.gov/globalhealth/newsletter/2023/jan-30-2023.html. Accessed 28 Dec 2023.
[103] World Health Organization. Neglected tropical diseases. 2023. https://www.who.int/health-topics/neglected-tropical-diseases#tab=tab_1. Accessed 28 Dec 2023.
[104] Reed SL, McKerrow JH. Why funding for neglected tropical diseases should be a global priority. Clin Infect Dis. 2018;67:323-6.
[105] Hotez PJ. The poverty-related neglected diseases: why basic research matters. PLoS Biol. 2017;15:2004186.
[106] Zamecnik A. Neglected tropical diseases: non-profits lead the way as private sector lags. Pharmaceut Tech. 30 June 2022. https://www.pharmaceutical-technology.com/features/neglected-tropical-diseases-non-profits-lead-the-way-as-private-sectors-lags/#:~:text=The%20World%20Health%20Organization%20(WHO,of%20NTDs%20in%20this%20decade. Accessed 28 Dec 2023.
[107] Cordell GA. Pharmacognosy: far from dead. Am Drug. 1987;195:96-8.
[108] Newton PN, Bond KC, Oxford Statement signatories. Global access to quality-assured medical products: the Oxford Statement and call to action. Lancet. 2019;7: e1609.
[109] Walsh CT, Tang Y. Natural product biosynthesis. Chemical logic and enzymatic machinery. London: Royal Society of Chemistry; 2017.
[110] Gairola S, Shariff NM, Bhatt A, Kala CP. Influence of climate change on production of secondary chemicals in high altitude medicinal plants: issues needs immediate attention. J Med Plants Res. 2010;4:1825-9.
[111] Ahmed S, Brinkley S, Smith E, Sela A, Theisen M, Thibodeau C, et al. Climate change and coffee quality: systematic review on the effects of environmental and management variation on secondary metabolites and sensory attributes of Coffea arabica and Coffea canephora. Front Plant Sci. 2021;12:708013.
[112] Albert A, Sareedenchai V, Heller W, Seidlitz HK, Zidorn C. Temperature is the key to altitudinal variation of phenolics in Arnica montana L. cv. ARBO. Oecologia. 2009;160:1-8.
[113] Caldwell CR, Britz SJ, Mirecki RM. Effect of temperature, elevated carbon dioxide, and drought during seed development on the isoflavone content of dwarf soybean [Glycine max (L.) Merrill] grown in controlled environments. J Agric Food Chem. 2005;53:1125-9.
[114] Canvin DT. The effect of temperature on the oil content and fatty acid composition of the oils from several oil seed crops. Can J Bot. 1965;43:63-9.
[115] Thomas JMG, Boote KJ, Allen LH Jr, Gallo-Meagher M, Davis JM. Elevated temperature and carbon dioxide effects on soybean seed composition and transcript abundance. Crop Sci. 2003;43:1548-57.
[116] Dannehl D, Huber C, Rocksch T, Huyskens-Keil S, Schmidt U. Interactions between changing climate conditions in a semi-closed greenhouse and plant development, fruit yield, and health-promoting plant compounds of tomatoes. Sci Hort. 2012;138:235-43.
[117] Selmar D, Kleinwächter M. Influencing the product quality by deliberately applying drought stress during the cultivation of medicinal plants. Ind Crops Prod. 2013;42:558-66.
[118] Al-Gabbies A, Kleinwächter M, Selmar D. Influencing the contents of secondary metabolites in spice and medicinal plants by deliberately applying drought stress during their cultivation. Jordan J Biol Sci. 2015;8:1-10.
[119] Al-Huqail A, El-Dakak RM, Sanad MN, Badr RH, Ibrahim MM, Soliman D, et al. Effects of climate temperature and water stress on plant growth and accumulation of antioxidant compounds in sweet basil (Ocimum basilicum L.) leafy vegetable. Scientifica. 2020;2020:3808909.
[120] Jochum GM, Mudge KW, Thomas RB. Elevated temperatures increase leaf senescence and root secondary metabolite concentrations in the understory herb Panax quinquefolius (Araliaceae). Am J Bot. 2007;4:819-26.
[121] Kaky E, Gilbert F. Predicting the distributions of Egypt’s medicinal plants and their potential shifts under future climate change. PLoS ONE. 2017;12: e0187714.
[122] Rana SK, Rana HK, Ghimire SK, Shrestha KK, Ranjitkar S. Predicting the impact of climate change on the distribution of two threatened Himalayan medicinal plants of Liliaceae in Nepal. J Mount Sci. 2017;14:558-70.
[123] Palit P, Mandal SC. Climate change, geographical location, and other allied triggering factors modulate the standardization and characterization of traditional medicinal plants: a challenge and prospect for phyto-drug development. In: Mandal SC, Chakraborty R, Sen S, editors. Evidence based validation of traditional medicines: a comprehensive approach. Singapore: Springer Nature; 2021.
[124] Tshabalala T, Mutanga O, Abdel-Rahman EM. Predicting the geographical distribution shift of medicinal plants in South Africa due to climate change. Conservation. 2022;2:694-708.
[125] Wu J, Li X, Huang L, Meng X, Hu H, Luo L, et al. A new GIS model for ecologically suitable distributions of medicinal plants. Chin Med. 2019;14:4.
[126] Pompe S, Hanspach J, Badeck F, Klotz S, Thuiller W, Kühn I. Climate and land use change impacts on plant distributions in Germany. Biol Lett. 2008;2008(4):564-7.
[127] Guo Y, Wei H, Lu C, Gao B, Gu W. Predictions of potential geographical distribution and quality of Schisandra sphenanthera under climate change. PeerJ. 2016;4: e2554.
[128] Zhao Q, Li R, Gao Y, Yao Q, Guo X, Wang W. Modeling impacts of climate change on the geographic distribution of medicinal plant Fritillaria cirrhosa D. Don Plant Biosyst. 2018;152:349-55.
[129] You J, Qin X, Ranjitkar S, Lougheed SC, Wang M, Zhou W, et al. Response to climate change of montane herbaceous plants in the genus Rhodiola predicted by ecological niche modelling. Sci Rep. 2018;8:5879.
[130] Abdelaal M, Fois M, Fenu G, Bacchetta G. Using MaxEnt modeling to predict the potential distribution of the endemic plant Rosa arabica Crép. in Egypt. Ecol Inform. 2019;50:68-75.
[131] Chen IC, Hill JK, Ohlemüller R, Roy DB, Thomas CD. Rapid range shifts of species associated with high levels of climate warming. Science. 2011;333:1024-6.
[132] Telwala Y, Brook BW, Manish K, Pandit MK. Climate-induced elevational range shifts and increase in plant species richness in a Himalayan biodiversity epicentre. PLoS ONE. 2013;8: e57103.
[133] Lamprecht A, Semenchuk PR, Steinbauer K, Winkler M, Pauli H. Climate change leads to accelerated transformation of high-elevation vegetation in the central Alps. New Phytol. 2018;220:447-59.
[134] Maharjan SK, Sterck FJ, Raes N, Zhao Y, Poorter L. Climate change induced elevational range shifts of Himalayan tree species. Biotropica. 2023;55:53-69.
[135] Kudo G, Ida TY. Early onset of spring increases the phenological mismatch between plants and pollinators. Ecology. 2013;94:2311-20.
[136] Phondani PC, Bhatt ID, Negi VS, Kothyari BP, Bhatt A, Maikhuri RK. Promoting medicinal plants cultivation as a tool for biodiversity conservation and livelihood enhancement in Indian Himalaya. J Asia-Pac Biodiv. 2016;9:39-46.
[137] Kharouba HM, Ehrlén J, Gelman A, Bolmgren K, Allen JM, Travers SE. Global shifts in the phenological synchrony of species interactions over recent decades. Proc Natl Acad Sci. 2018;115:5211-6.
[138] Huang J, Wang P, Niu Y, Yu H, Ma F, Xiao G, et al. Changes in C:N: P stoichiometry modify N and P conservation strategies of a desert steppe species Glycyrrhiza uralensis. Sci Rep. 2018;8:12668.
[139] Zhang J-T, Xu B, Li M. Diversity of communities dominated by Glycyrrhiza uralensis, an endangered medicinal plant species, along a precipitation gradient in China. Bot Stud. 2011;52:493-501.
[140] Brinckmann JA. Geographical indications for medicinal plants: globalization, climate change, quality and market implications for geo-authentic botanicals. World J Tradit Chin Med. 2015;1:16-23.
[141] Bentz BJ, Régnière J, Fettig CJ, Hansen EM, Hayes JL, Hicke JA, et al. Climate change and bark beetles of the Western United States and Canada: direct and indirect effects. Bioscience. 2010;60:602-13.
[142] Amberson JT, Keville MP, Nelson CR. Effects of disturbance on tree community dynamics in whitebark pine (Pinus albicaulis. Engelm) ecosystems. Forests. 2018;9:566.
[143] Martens WJ, Niessen LW, Rotmans J, Jetten TH, McMichael AJ. Potential impact of global climate change on malaria risk. Environ Health Persp. 1995;103:458-64.
[144] Ogden NH, Lindsay LR. Effects of climate and climate change on vectors and vector-borne diseases: ticks are different. Trends Parasitol. 2016;32:646-56.
[145] Caminade C, McIntyre KM, Jones AE. Impact of recent and future climate change on vector-borne diseases. Ann NY Acad Sci. 2019;1436:157-73.
[146] Rocklöv J, Dubrow R. Climate change: an enduring challenge for vector-borne disease prevention and control. Nat Immunol. 2020;21:479-83.
[147] Onyango EA, Sahin O, Awiti A, Chu C, Mackey B. An integrated risk and vulnerability assessment framework for climate change and malaria transmission in East Africa. Malaria J. 2016;15:1-12.
[148] Ren Z, Wang D, Ma A, Hwang J, Bennett A, Sturrock HJW, et al. Predicting malaria vector distribution under climate change scenarios in China: challenges for malaria elimination. Sci Rep. 2016;6:20604.
[149] Eikenberry SE, Gumel AB. Mathematical modeling of climate change and malaria transmission dynamics: a historical review. J Math Biol. 2018;77:857-933.
[150] Ryan SJ, Lippi CA, Zermoglio F. Shifting transmission risk for malaria in Africa with climate change: a framework for planning and intervention. Malaria J. 2020;19:1-14.
[151] Mace KE, Lucchi NW, Tan KR. Malaria surveillance-United States, 2017. MMWR Surv Summ. 2021;70:1-35.
[152] Turner NJ, Clifton H. “It?s so different today”: Climate change and indigenous lifeways in British Columbia, Canada. Glob Environ Change. 2009;19:180-90.
[153] Ruelle ML, Kassam K-AS. Diversity of plant knowledge as an adaptive asset: a case study with Standing Rock elders. Econ Bot. 2011;65:295-307.
[154] Williams J. The impact of climate change on indigenous people-the implications for the cultural, spiritual, economic and legal rights of indigenous people. Int J Human Rights. 2012;16:648-88.
[155] Cajete GA. Indigenous science, climate change, and indigenous community building: a framework of foundational perspectives for indigenous community resilience and revitalization. Sustainability. 2020;12:9569.
[156] Cahyaningsih R, Phillips J, Magos Brehm J, Gaisberger H, Maxted N. Climate change impact on medicinal plants in Indonesia. Glob Ecol Conserv. 2021;30: e01752.
[157] Tangjitman K, Trisonthi C, Wongsawad C, Jitaree S, Svenning JC. Potential impact of climatic change on medicinal plants used in the Karen women’s health care in Northern Thailand. Songklanakarin J Sci Technol. 2015;37:369-79.
[158] Sentinella AT, Warton DI, Sherwin WB, Offord CA, Moles AT. Tropical plants do not have narrower temperature tolerances, but are more at risk from warming because they are close to their upper thermal limits. Glob Ecol Biogeogr. 2020;29:13871398.
[159] Braun LA, Tiralongo E, Wilkinson JM, Spitzer O, Bailey M, Poole S, et al. Perceptions, use and attitudes of pharmacy customers on complementary medicines and pharmacy practice. BMC Complem Altern Med. 2010;10:1-7.
[160] Tangkiatkumjai M, Boardman H, Walker D-M. Potential factors that influence usage of complementary and alternative medicine worldwide: a systematic review. BMC Complem Med Ther. 2020;20:1-15.
[161] Zörgő S, Peters G-JY, Mkhitaryan S. Attitudes underlying reliance on complementary and alternative medicine. Integr Cancer Ther. 2020. https://doi.org/10.1177/1534735420910472.
[162] Li Y, Shen Y, Yao C-l, Guo D-A. Quality assessment of herbal medicines based on chemical fingerprints combined with chemometrics approach: a review. J Pharm Biomed Anal. 2020;2020(185): 113215.
[163] Cohen PA, Avula B, Wang Y-H, Katragunta K, Khan I. Quantity of melatonin and CBD in melatonin gummies sold in the US. J Amer Med Assoc. 2023;329:1401-2.
[164] Gafner S, Blumenthal M, Foster S, Cardellina JH, Khan IA, Upton R. Botanical ingredient forensics: detection of attempts to deceive commonly used analytical methods for authenticating herbal dietary and food ingredients and supplements. J Nat Prod. 2023;86:460-72.
[165] World Health Organization. 1 in 10 medical products in developing countries is substandard or falsified. November 2017. https://www.who.int/news/item/28-11-2017-1-in-10-medical-products-in-developing-countries-is-substandard-or-falsified. Accessed 28 Dec 2023.
[166] Ichim MC. The DNA-based authentication of commercial herbal products reveals their globally widespread adulteration. Front Pharmacol. 2019;10:1227.
[167] Ichim MC, Booker A. Chemical authentication of botanical ingredients: a review of commercial herbal products. Front Pharmacol. 2021;12: 666850.
[168] Gunningham N. Environment, self-regulation, and the chemical industry: assessing responsible care. Law Policy. 1995;17:57-109.
[169] Grande D. Limiting the influence of pharmaceutical industry gifts on physicians: self-regulation or government intervention? J Gen Intern Med. 2010;25:79-83.
[170] Sharma LL, Teret SP, Brownell KD. The food industry and self-regulation: standards to promote success and to avoid public health failures. Am J Publ Health. 2010;100:240-6.
[171] Lall R. From failure to failure: the politics of international banking regulation. Rev Internat Polit Econ. 2012;19:609-38.
[172] Ackermann K, Stehle JH. Melatonin synthesis in the human pineal gland: advantages, implications, and difficulties. Chronobiol Int. 2006;23:369-79.
[173] Smith T, Resetar H, Morton C. US sales of herbal supplements increase by 9.7% in 2021. HerbalGram. 2022;136:42-69.
[174] World Health Organization. Traditional and modern medicine. Harmonizing the two approaches. Geneva: World Health Organization; 2000.
[175] Zhao W, Jin Y, Karinshak E. Building trust and empowering informed decisions: effects of risk disclosure and call to action on young adults’ responses to dietary supplement advertising. Int J Pharm Hlthcare Mark. 2023;17:249-64.
[176] Angraal S, Krumholz HM, Schulz L. Blockchain technology: applications in health care. Cardiovasc Qual Out. 2017;10: e003800.
[177] Javaid M, Haleem A, Singh RP, Khan S, Suman R. Blockchain technology applications for Industry 4.0: a literature-based review. Blockchain Res Appl. 2021;2: 100027.
[178] Lim MK, Li Y, Wang C, Tseng M-L. A literature review of blockchain technology applications in supply chains: a comprehensive analysis of themes, methodologies and industries. Comput Ind Eng. 2021;154:107133.
[179] Galati A, Vrontis D, Giorlando B, Giacomarra M, Crescimanno M. Exploring the common blockchain adoption enablers: the case of three Italian wineries. Int J Wine Bus Res. 2021;33:578-96.
[180] Silvestri R, Adamashvili N, Fiore M, Galati A. How blockchain technology generates a trust-based competitive advantage in the wine industry: a resource based view perspective. Eur Bus Rev. 2023. https://doi.org/10.1108/EBR-10-2022-0217/full/html.
[181] Feng H, Wang X, Duan Y, Zhang J, Zhang X. Applying blockchain technology to improve agri-food traceability: a review of development methods, benefits and challenges. J Clean Prod. 2020;260:121031.
[182] Xu J, Guo S, Xie D, Yan Y. Blockchain: a new safeguard for agri-foods. Art Int Agr. 2020;2020(4):153-61.
[183] Larkman T. Block chain traceability for tea tree oil. Part 2. Wagga Wagga: Agrifutures Australia; 2020.
[184] Heinrich M, Scotti F, Booker A, Fitzgerald M, Kum KY, Löbel K. Unblocking high-value botanical value chains: is there a role for blockchain systems? Front Pharmacol. 2019;10:396.
[185] Saberi S, Kouhizadeh M, Sarkis J, Shen L. Bloc