Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus

doi:10.1007/s13659-023-00410-2

Natural Products and Bioprospecting ›› 2023, Vol. 13 ›› Issue (6): 46-46.DOI: 10.1007/s13659-023-00410-2

• ORIGINAL ARTICLE • Previous Articles Next Articles

Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus

Jing Fan¹, Pai Liu², Kuan Zhao³, He-Ping Chen¹

1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China;
2. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China;
3. College of Life Science, Jiangxi Science & Technology Normal University, Nanchang, 330013, China

Received:2023-08-29 Online:2023-12-26 Published:2023-12-24
Contact: Kuan Zhao,E-mail:1020160918@jxstnu.edu.cn;He-Ping Chen,E-mail:chenhp@mail.scuec.edu.cn
Supported by:
This work was financially supported by the National Natural Science Foundation of China (grant number 81903512) and the Fundamental Research Funds for the Central Universities, South-Central Minzu University (Grant Number CPT22033). The authors thank the Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central Minzu University for the spectra test.

Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus

Jing Fan¹, Pai Liu², Kuan Zhao³, He-Ping Chen¹

1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China;
2. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China;
3. College of Life Science, Jiangxi Science & Technology Normal University, Nanchang, 330013, China

通讯作者: Kuan Zhao,E-mail:1020160918@jxstnu.edu.cn;He-Ping Chen,E-mail:chenhp@mail.scuec.edu.cn
基金资助:
This work was financially supported by the National Natural Science Foundation of China (grant number 81903512) and the Fundamental Research Funds for the Central Universities, South-Central Minzu University (Grant Number CPT22033). The authors thank the Analytical & Measuring Center, School of Pharmaceutical Sciences, South-Central Minzu University for the spectra test.

Abstract

Abstract: Three previously undescribed compounds, cordycicadione (1), cordycicadin F (2), and 7-hydroxybassiatin (3), were isolated from the cultures of Cordyceps cicadae JXCH1, an entomopathogenic fungus. Their structures and relative configurations were elucidated primarily by NMR spectroscopic analysis. The absolute configurations of 1 and 2 were determined by ECD calculations. Single-crystal X-ray diffraction method was adopted to determine the absolute configuration of 3. Compound 2 is a polycyclic polyketide with an unusual enol ether moiety and a spiro ring. The compounds obtained in this study were subjected to screening their inhibition against the proliferation of the human lung cancer cell line A549 and the production of nitric oxide in murine macrophages RAW264.7.

Key words: Insect pathogenic fungus, Cordyceps cicadae, Steroid, Polyketide, Cyclic dipeptide

摘要： Three previously undescribed compounds, cordycicadione (1), cordycicadin F (2), and 7-hydroxybassiatin (3), were isolated from the cultures of Cordyceps cicadae JXCH1, an entomopathogenic fungus. Their structures and relative configurations were elucidated primarily by NMR spectroscopic analysis. The absolute configurations of 1 and 2 were determined by ECD calculations. Single-crystal X-ray diffraction method was adopted to determine the absolute configuration of 3. Compound 2 is a polycyclic polyketide with an unusual enol ether moiety and a spiro ring. The compounds obtained in this study were subjected to screening their inhibition against the proliferation of the human lung cancer cell line A549 and the production of nitric oxide in murine macrophages RAW264.7.

关键词: Insect pathogenic fungus, Cordyceps cicadae, Steroid, Polyketide, Cyclic dipeptide

Jing Fan, Pai Liu, Kuan Zhao, He-Ping Chen. Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus[J]. Natural Products and Bioprospecting, 2023, 13(6): 46-46.

Jing Fan, Pai Liu, Kuan Zhao, He-Ping Chen. Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus[J]. 应用天然产物, 2023, 13(6): 46-46.

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Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus

Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus

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