Abstract: Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H (1), J (2), K (3), momorcharacoside A (4), goyaglycoside-L (5), and five known compounds (6-10), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their ¹³C NMR data with literature reported values. All compounds were evaluated for their inhibition against α-glucosidase, in which compounds 2, 5, 7, 8, 9 showed moderate inhibitory activities with IC₅₀ values ranging from 28.40 to 63.26 μM comparing with the positive control (acarbose, IC₅₀ 87.65±6.51 μM).

Key words: Momordica charantia, Cucurbitane-type triterpene glycosides, α-Glucosidase inhibitory activity

摘要： Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H (1), J (2), K (3), momorcharacoside A (4), goyaglycoside-L (5), and five known compounds (6-10), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their ¹³C NMR data with literature reported values. All compounds were evaluated for their inhibition against α-glucosidase, in which compounds 2, 5, 7, 8, 9 showed moderate inhibitory activities with IC₅₀ values ranging from 28.40 to 63.26 μM comparing with the positive control (acarbose, IC₅₀ 87.65±6.51 μM).

关键词: Momordica charantia, Cucurbitane-type triterpene glycosides, α-Glucosidase inhibitory activity