Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

doi:10.1007/s13659-019-00218-z

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (5): 345-349.DOI: 10.1007/s13659-019-00218-z

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Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

Zaenal Sugiyanto^1,2, Benediktus Yohan³, Soeharyo Hadisaputro^2,4, Edi Dharmana^2,4, Catharina Suharti^2,4, Winarto^2,4, Kis Djamiatun⁴, Fifin L. Rahmi⁴, R. Tedjo Sasmono³

1 Faculty of Health Science, Dian Nuswantoro University, Jl. Imam Bonjol 270, Semarang 50131, Indonesia;
2 Doctoral Program in Medical and Health Sciences, Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto SH, Tembalang, Semarang 50275, Indonesia;
3 Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jl. Diponegoro 69, Jakarta 10430, Indonesia;
4 Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto SH, Tembalang, Semarang 50275, Indonesia

Received:2019-08-07 Revised:2019-09-10 Online:2019-10-30 Published:2019-10-24
Contact: R. Tedjo Sasmono
Supported by:
We would like to thank the donor involved in this study. Financial and managerial supports from Dian Nuswantoro University are greatly acknowledged.

Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

Zaenal Sugiyanto^1,2, Benediktus Yohan³, Soeharyo Hadisaputro^2,4, Edi Dharmana^2,4, Catharina Suharti^2,4, Winarto^2,4, Kis Djamiatun⁴, Fifin L. Rahmi⁴, R. Tedjo Sasmono³

1 Faculty of Health Science, Dian Nuswantoro University, Jl. Imam Bonjol 270, Semarang 50131, Indonesia;
2 Doctoral Program in Medical and Health Sciences, Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto SH, Tembalang, Semarang 50275, Indonesia;
3 Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jl. Diponegoro 69, Jakarta 10430, Indonesia;
4 Faculty of Medicine, Diponegoro University, Jl. Prof. Sudarto SH, Tembalang, Semarang 50275, Indonesia

通讯作者: R. Tedjo Sasmono
基金资助:
We would like to thank the donor involved in this study. Financial and managerial supports from Dian Nuswantoro University are greatly acknowledged.

Abstract

Abstract: Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin against dengue virus (DENV) infection in human peripheral blood mononuclear cells (PBMC) by the measurement of virus titer and TNF-α and IFN-γ cytokines concentration post infection. Increasing concentration of α-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24- and 48-h post infection. Our results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.

Key words: Dengue, Antiviral, Mangostin, Cytokine, PBMC

摘要： Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin against dengue virus (DENV) infection in human peripheral blood mononuclear cells (PBMC) by the measurement of virus titer and TNF-α and IFN-γ cytokines concentration post infection. Increasing concentration of α-mangostin inhibited virus replication and reduced inflammatory cytokines expression at 24- and 48-h post infection. Our results support the potential use of α-mangostin as anti-antiviral and anti-inflammatory therapies in the treatment of dengue.

关键词: Dengue, Antiviral, Mangostin, Cytokine, PBMC

Zaenal Sugiyanto, Benediktus Yohan, Soeharyo Hadisaputro, Edi Dharmana, Catharina Suharti, Winarto, Kis Djamiatun, Fifin L. Rahmi, R. Tedjo Sasmono. Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells[J]. Natural Products and Bioprospecting, 2019, 9(5): 345-349.

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Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

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