Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

doi:10.1007/s13659-019-00220-5

Abstract

Abstract: Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders.

Key words: Anti-leishmanial, Anti-inflammatory, Endophytes, Bioactive metabolites

摘要： Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders.

关键词: Anti-leishmanial, Anti-inflammatory, Endophytes, Bioactive metabolites

Rufin Marie Kouipou Toghueo. Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review[J]. Natural Products and Bioprospecting, 2019, 9(5): 311-328.

Rufin Marie Kouipou Toghueo. Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review[J]. 应用天然产物, 2019, 9(5): 311-328.

References

1. A.L. Harvey, R. Edrada-Ebel, R.J. Quinn, Nat. Rev. Drug Discov. 14, 111-129 (2015)
2. B. Shen, Cell 163, 1297-1300 (2015)
3. D.J. Newman, G.M. Cragg, J. Nat. Prod. 79, 629-661 (2016)
4. L. Katz, R.H. Baltz, J. Ind. Microbiol. Biotechnol. 43, 155-176 (2016)
5. N.P. Keller, Nat. Rev. Microbiol. (2018). https://doi.org/10.1038/s41579-018-0121-1
6. C.C. Thornburg, J.R. Britt, J.R. Evans, R.K. Akee, J.A. Whitt, S.K. Trinh, M.J. Harris, J.R. Thompson, T.L. Ewing, S.M. Shipley, P.G. Grothaus, D.J. Newman, J.P. Schneider, T. Grkovic, B.R. O'Keefe, A.C.S. Chem, Biol. (2018). https://doi.org/10.1021/acsch embio.8b003 89
7. G. Niu, W. Li, Trends Biochem. Sci. (2019). https://doi.org/10.1016/j.tibs.2019.05.005
8. G. Strobel, J. Fungi 4, 57 (2018)
9. M. Jia, L. Chen, H.-L. Xin, C.-J. Zheng, K. Rahman, T. Han, L.-P. Qin, Front. Microbiol. 7, 906 (2016)
10. H.F. Ji, X.J. Li, H.Y. Zhang, EMBO Rep. 10, 194-200 (2009). https://doi.org/10.1038/embor.2009.12
11. B. Joseph, R. MiniPriya, Am. J. Biochem. Mol. Biol. 3, 291-309 (2011)
12. K.R.M. Toghueo, Mycology. (2019). https://doi.org/10.1080/21501203.2019.16450 53
13. M.J. Allison, in Cambridge World History of Human Disease, ed. by K.F. Kiple (Cambridge University Press, Cambridge, 1993)
14. World Health Organization. Global Health Observatory (GHO) data. https://www.who.int/gho/neglected_diseases/leishmaniasis/en/(2018).
15. E. Hasker, S. Kansal, P. Malaviya, K. Gidwani, A. Picado, R.P. Singh, A. Chourasia, A.K. Singh, R. Shankar, J. Menten, M.E. Wilson, M. Boelaert, S. Sundar, PLoS Negl. Trop. Dis. 7(2), e2053 (2013)
16. S. Hewitt et al., Trans. R. Soc. Trop. Med. Hyg., 92, 273-274 (1998)
17. J. Alvar, P. Aparicio, A. Aseffa, M. Den Boer, C. Canavate, J.-P. Dedet, L. Gradoni, R. Ter Horst, R. Lopez-Velez, J. Moreno, Clin. Microbiol. Rev. 21, 334-359 (2008)
18. J. Alvar, I.D. Velez, C. Bern, M. Herrero, P. Desjeux, J. Cano, J. Jannin, M. den Boer, WHO Leishmaniasis Control Team. PLoS ONE 7, e35671 (2012)
19. S. Burza, R. Mahajan, P.K. Sinha, J. van Griensven, K. Pandey, M.A. Lima, M.G. Sanz, T. Sunyoto, S. Kumar, G. Mitra, PLoS Negl. Trop. Dis. 8, e3053 (2014)
20. S. Rijal, B. Ostyn, S. Uranw, K. Rai, N.R. Bhattarai, T.P.C. Dorlo, J.H. Beijnen, M. Vanaerschot, S. Decuypere, S.S. Dhakal, M.L. Das, P. Karki, R. Singh, M. Boelaert, J.-C. Dujardin, Clin. Infect. Dis. 56, 1530-1538 (2013). https://doi.org/10.1093/cid/cit102
21. T.P. Dorlo, et al., J. Infect. Dis. 210, 146-153 (2014)
22. M. Wasunna, S. Njenga, M. Balasegaram, N. Alexander, R. Omollo, T. Edwards, TP. Dorlo, B. Musa, MH. Ali, MY. Elamin, G. Kirigi, R. Juma, AE. Kip, GJ. Schoone, A.Hailu, J. Olobo, S. Ellis, R. Kimutai, S. Wells, E.A. Khalil, N. Strub Wourgaft, F. Alves, A. Musa, PLoS Negl. Trop. Dis. 10, e0004880 (2016)
23. J. Alvar, B. Arana, Drug Discovery for Leishmaniasis (The Royal Society of Chemistry, London, 2018)
24. S.J. Higginbotham, A.E. Arnold, A. Ibannez, C. Spadafora, P.D. Coley et al., PLoS ONE 8, e73192 (2013). https://doi.org/10.1371/journal.pone.0073192
25. H.L. Rosa, V.N. Gonçalves, RB. Caligiorne, T.M.A. Alves, A. Rabello, P.A. Sales, A.J. Romanha, M.E.G. Sobral, C.A. Rosa, CL. Zani, Braz. J. Microbiol. 41, 420-430 (2010)
26. S. Martínez-Luis, G. Della-Togna, P.D. Coley, T.A. Kursar, W.H. Gerwick, L. Cubilla-Rios, J. Nat. Prod. 71, 2011-2014 (2008). https://doi.org/10.1021/np800472q
27. H.E. Ortega, M. Teixeira Ede, A. Rabello, S. Higginbotham, L. Cubilla-Ríos, Nat. Prod. Commun. 9, 95-98 (2014)
28. E. Moreno, T. Varughese, C. Spadafora, A.E. Arnold, P.D. Coley, T.A. Kursar, W.H. Gerwick, L. Cubilla-Rios, Nat. Prod. Commun. 6, 835-840 (2011)
29. B.N. Lenta, J. Ngatchou, M. Frese, F. Ladoh-Yemeda, S. Voundi, F. Nardella, C. Michalek, D. Wibberg, S. Ngouela, E. Tsamo, M. Kaiser, J. Kalinowski, N. Sewald, Zeitschrift Für Naturforschung B 71, 1159-1167 (2016). https://doi.org/10.1515/znb-2016-0128
30. S.R. Ibrahim, H.M. Abdallah, G.A. Mohamed, S.A. Ross, Fitoterapia 112, 161-167 (2016)
31. E.S. Elkhayat, S.R. Ibrahim, G.A. Mohamed, S.A. Ross, Nat. Prod. Res. 30, 814-820 (2016)
32. F.F. Campos, L.H. Rosa, B.B. Cota, R.B. Caligiorne, A.L. Teles Rabello, et al., PLoS Negl. Trop. Dis. 2, e348 (2008). https://doi.org/10.1371/journal.pntd.0000348
33. A.M. do Nascimento, M.G. Soares, F.K. da Silva Torchelsen, J.A. de Araujo, P.S. Lage, M.C. Duarte, P.H. Andrade, T.G. Ribeiro, E.A. Coelho, World J. Microbiol. Biotechnol. 31, 1793-1800 (2015). https://doi.org/10.1007/s11274-015-1932-0
34. B.B. Cota, L.G. Tunes, D.N.B. Maia, J.P. Ramos, D.M. Oliveira, M. Kohlhoff, T.M.A. Alves, E.M. Souza-Fagundes, F.F. Campos, C.L. Zani, Mem. Inst. Oswaldo Cruz. 113, 102-110 (2018)
35. S. Martínez-Luis, L. Cherigo, E. Arnold, C. Spadafora, W.H. Gerwick, L. Cubilla-Rios, Nat. Prod. Commun. 7, 165-168 (2012)
36. A.M. Metwaly, H.A. Kadry, A.A. El-Hela, A.I. Mohammad, G. Ma, S.J. Cutler, S.A. Ross, Phytochem. Lett. 7, 1-5 (2014)
37. W.J. Andrioli, R. Conti, M.J. Araújo, R. Zanasi, B.C. Cavalcanti, V. Manfrim, J.S. Toledo, D. Tedesco, M.O. de Moraes, C. Pessoa, A.K. Cruz, C. Bertucci, J. Sabino, D.N. Nanayakkara, M.T. Pupo, J.K. Bastos, J. Nat. Prod. 77, 70-78 (2014). https://doi.org/10.1021/np4006822
38. T.T. de Almeida, M.A.D.S. Ribeiro, J.C. Polonio, F.P. Garcia, C.V. Nakamura, E.C. Meurer, M.H. Sarragiotto, D.C. Baldoqui, J.L. Azevedo, J.A. Pamphile, Nat. Prod. Res. 32, 2783-2790 (2018). https://doi.org/10.1080/14786419.2017.1380011
39. A.M. Zaher, M.A. Makboul, A.M. Moharram, B.L. Tekwani, A.I. Calderón, J. Antibiot. (Tokyo). 68, 197-200 (2015)
40. D.R. Alves, S.M. Morais, F. Tomiotto-Pellissier, F.R. Vasconcelos, FDCO. Freire, INGD. Silva, A.H.D. Cataneo, M.M. Miranda-Sapla, G.A.S. Pinto, I. Conchon-Costa, A.A.A. Noronha, W.R. Pavanelli, PLoS ONE. 13, e0196796 (2018). https://doi.org/10.1371/journal.pone.0196796
41. A.H. Tarawneh, F. León, M.M. Radwan, L.H. Rosa, S.J. Cutler, Nat. Prod. Commun. 8, 1285-1288 (2013)
42. G. Majno, The Healing Hand:Man and Wound in the Ancient World (Harvard University Press, Cambridge 1975)
43. R. Medzhitov, Cell 140, 771-776 (2010)
44. L. Chen, H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Y. Li, X. Wang, L. Zhao, Oncotarget. 9, 7204-7218 (2017)
45. E.M. Carvalho, R. Badaró, S.G. Reed, T.C. Jones, W.D. Johnson, J. Clin. Invest. 76, 2066-2069 (1985)
46. O. Bacellar, A. D'Oliveira, S. Jerônimo, E.M. Carvalho, Cytokine 12, 1228-1231 (2000)
47. A.S.A. Costa, G.C. Costa, D.M.C. de Aquino, V.R.R. de Mendonça, A. Barral, M. Barral-Netto, A.J.M. de Caldas, Mem. Do Inst. Osw. Cruz 107(6), 735-739 (2012)
48. D.S. Lima-Junior, D.L. Costa, V. Carregaro, L.D. Cunha, A.L.N. Silva, T.W.P. Mineo, F.R.S. Gutierrez, M. Bellio, R.K. Bortoluci, A.R. Flavell, T.M. Bozza, S.J. Silva, D.S. Zamboni, Nat. Med. 19(7), 909-915 (2013). https://doi.org/10.1038/nm.3221
49. V. Peruhype-Magalhães, O.A. Martins-Filho, A. Prata, L.D.A. Silva, A. Rabello, A. Teixeira-Carvalho, R.M. Figueiredo, S.F. Guimarães-Carvalho, T.C.A. Ferrari, J. Van Weyenbergh, R. Correa-Oliveira, Clin. Exp. Immun. 146, 124-132 (2006)
50. I.P. Barcelos, R.M. Troxell, J.S. Graves, Biology (Basel). 8, E37 (2019)
51. D.H. Tsai, M. Riediker, A. Berchet, F. Paccaud, G. Waeber, P. Vollenweider, M. Bochud, Environ. Sci. Pollut. Res. Int. 26, 19697-19704 (2019)
52. P. Deepak, J.E. Axelrad, A.N. Ananthakrishnan, Gastrointest. Endosc. Clin. N. Am. 29, 447-470 (2019)
53. R. Pahwa, I. Jialal, https://www.ncbi.nlm.nih.gov/books/NBK493173/(2019)
54. L.J. Crofford, Arthritis Res. Ther. 15, S2 (2013). https://doi.org/10.1186/ar4174
55. S. Wongrakpanich, A. Wongrakpanich, K. Melhado, J. Rangaswami Aging Dis. 9, 143-150 (2018). https://doi.org/10.14336/AD.2017.0306
56. A. Venieraki, M. Dimou, P. Katinakis, Hellenic Plant Prot. J. 10, 51-66 (2017)
57. C. Su, Q.L. Ming, K. Rahman, T. Han, L. Qin, Chin. J. Nat. Med. 13, 163-182 (2015)
58. W. Chen, G. Chen, Danshen Curr. Pharm. Des. 23, 5125-5135 (2017)
59. G.W. Fan, X.M. Gao, H. Wang, Y. Zhu, J. Zhang, L.M. Hu et al., J. Steroid Biochem. 113, 275-280 (2009). https://doi.org/10.1016/j.jsbmb.2009.01.011
60. Z. Jiang, W. Gao, L. Huang, Front. Pharm. (2019). https://doi.org/10.3389/fphar.2019.00202
61. Q. Ming, T. Han, W. Li, Q. Zhang, H. Zhang, C. Zheng, F. Huang, K. Rahman, L. Qin, Phytomedicine 19, 330-333 (2012). https://doi.org/10.1016/j.phyme d.2011.09.076
62. Q. Ming, C. Su, C. Zheng, M. Jia, Q. Zhang, H. Zhang, K. Rahman, T. Han, L. Qin, J. Exp. Bot. 64, 5687-5694 (2013). https://doi.org/10.1093/jxb/ert342
63. J.H. Ho, C.Y. Hong, J. Biomed. Sci. 18, 30 (2011). https://doi.org/10.1186/1423-0127-18-30
64. X. Li, X. Zhai, Z. Shu, R. Dong, Q. Ming, L. Qin, C. Zheng, Curr. Microbiol. 73(1), 31-37 (2016). https://doi.org/10.1007/s00284-016-1023-y
65. A.M. Mujumdar, J.N. Dhuley, V.K. Deshmukh, P.H. Raman, S.R. Naik, Jpn. J. Med. Sci. Biol. 43, 95-100 (1990)
66. J.R. Stohr, P.G. Xiao, R. Bauer, J. Ethnopharmacol. 75, 133-139 (2001)
67. J.S. Bang, D.H. Oh, H.M. Choi, B.J. Sur, S.J. Lim, J.Y. Kim, H.I. Yang, M.C. Yoo, D.H. Hahm, K.S. Kim, Arthritis Res. Ther. 11, R49 (2009). https://doi.org/10.1186/ar2662
68. S. Chithra, B. Jasim, P. Sachidanandan, M. Jyothis, E.K. Radhakrishnan, Phytomedicine 21, 534-540 (2014). https://doi.org/10.1016/j.phymed.2013.10.020
69. V. Mahajan, N. Sharma, S. Kumar, V. Bhardwaj, A. Ali, R.K. Khajuria, Y.S. Bedi, R.A. Vishwakarma, S.G. Gandhi, Pharm. Biol. 53, 446-450 (2015)
70. S.K. Jain, S.B. Bharate, R.A. Vishwakarma, Mini-Rev. Med. Chem. 12, 632-649 (2012)
71. U.K. Schmerwitz, G. Sass, A.G. Khandoga, J. Joore, B.A. Mayer, N. Berberich, F. Totzke, F. Krombach, G. Tiegs, S. Zahler, A.M. Vollmar, R. Fürst, Arterioscler. Thromb. Vasc. Biol. 3, 280-288 (2011)
72. P. Mohana Kumara, S. Zuehlke, V. Priti, B.T. Ramesha, S. Shweta, G. Ravikanth, R. Vasudeva, T.R. Santhoshkumar, M. Spiteller, R. Uma Shaanker, Antonie Van Leeuwenhoek 101, 323-329 (2012) https://doi.org/10.1007/s10482-011-9638-2
73. P.M. Kumara, K.N. Soujanya, G. Ravikanth, R. Vasudeva, K.N.Ganeshaiah, R. Uma Shaanker, Phytomedicine 21, 541-546 (2014)
74. X. You, S. Feng, S. Luo, D. Cong, Z. Yu, Z. Yang, J. Zhang, Fitoterapia 85, 161-168 (2013)
75. A. Harun, S. Vidyadaran, S.M. Lim, A.L. Cole, K. Ramasamy, BMC Complement Altern. Med. 15, 166 (2015). https://doi.org/10.1186/s12906-015-0685-5
76. N. Abutaha, A. Semlali, A. Baabbad, M. Al-Shami, M. Alanazi, M.A. Wadaan, Pak. J. Pharm. Sci. 31, 421-427 (2018)
77. M. Govindappa, R. Channabasava, D. Sowmya, J. Meenakshi, M. Shreevidya, A. Lavanya, T. Sadananda, Pharmacognosy J. 3, 82-90 (2011)
78. S. Shoba, M. Sathiavelu, Indian J. Pharm. Edu. Res 52, 2747-3283 (2018)
79. B.S. de Barros, J.P. da Silva, J.N. de Souza Ferro, I.K. Agra, F. de Almeida Brito, E.D. Albuquerque, LC. Caetano, E. Barreto, J. Nat. Med. 65, 526-531 (2011)
80. A.M. Abdel-Azeem, S.M. Zaki, W.F. Khalil, N.A. Makhlouf, L.M. Farghaly, Front. Microbiol. 7, 1477 (2016)
81. K. Ruma, K. Sunil, H.S. Prakash, Pharm. Biol. 52, 665-676 (2014)
82. Q. Zhang, R. Luan, H. Li, Y. Liu, P. Liu, L. Wang, D. Li, M. Wang, Q. Zou, H. Liu, K. Matsuzaki, F. Zhao, Exp. Ther. Med. 16, 1538-1546 (2018). https://doi.org/10.3892/etm.2018.6294
83. G. Ding, Y. Li, S. Fu, S. Liu, J. Wei, Y. Che, J. Nat. Prod. 72, 182-186 (2009)
84. R. Lin, H. Kim, J. Hong, Q.J. Li, A.C.S. Med, Chem. Lett. 5, 485-490 (2014)
85. W.-G. Lee, W.-S. Kim, S.-G. Park, H. Kim, J. Hong, H. Ko, Y.-C. Kim, ChemMedChem 7, 218-222 (2011). https://doi.org/10.1002/cmdc.201100409
86. A. Pretsch, M. Nagl, K. Schwendinger, B. Kreiseder, M. Wiederstein, D. Pretsch, M. Genov, R. Hollaus, D. Zinssmeister, A. Debbab, H. Hundsberger, A. Eger, P. Proksch, C. Wiesner, PLoS ONE 9, e97929 (2014). https://doi.org/10.1371/journal.pone.0097929
87. D.S. El-Agamy, S.R.M. Ibrahim, N. Ahmed, S. Khoshhal, H.M. Abo-Haded, M.A. Elkablawy, N. Aljuhani, G.A. Mohamed, Int. Immunopharmacol. 72, 429-436 (2019)
88. F. Guo, Z. Li, X. Xu, K. Wang, M. Shao, F. Zhao, H. Wang, H. Hua, Y. Pei, J. Bai, Fitoterapia 113, 44-50 (2016). https://doi.org/10.1016/j.fitote.2016.06.014
89. H. Xue, Q. Xu, C. Lu, Y. Shen, Drug Discov. Ther. 8, 208-211 (2014)
90. C. Qi, W. Gao, J. Wang, M. Liu, J. Zhang, C. Chen, Z. Hu, Y. Xue, D. Li, Q. Zhang, Y. Lai, Q. Zhou, H. Zhu, Y. Zhang, Fitoterapia 130, 134-139 (2018)
91. Y.S. Shi, Y. Zhang, X.Z. Chen, N. Zhang, Y.B. Liu, Molecules 20, 10793-10799 (2015)
92. S.K. Deshmukh, P.D. Mishra, A. Kulkarni-Almeida, S. Verekar, M.R. Sahoo, G. Periyasamy, H. Goswami, A. Khanna, A. Balakrishnan, R. Vishwakarma, Chem. Biodivers. 6, 784-789 (2009)
93. X. Wang, D.E. Wedge, S.J. Cutler, Nat. Prod. Commun. 11, 1595-1600 (2016)
94. D. Weber, O. Sterner, T. Anke, S. Gorzalczancy, V. Martino, C. Acevedo, J. Antibiot. 57, 559-563 (2004)
95. B.C. Yan, W.G. Wang, D.B. Hu, X. Sun, L.M. Kong, X.N. Li, X. Du, S.H. Luo, Y. Liu, Y. Li, H.D. Sun, J.X. Pu, Org. Lett. 18, 1108-1111 (2016). https://doi.org/10.1021/acs.orglett.6b00214
96. Z. Hu, Y. Wu, S. Xie, W. Sun, Y. Guo, X.N. Li, J. Liu, H. Li, J. Wang, Z. Luo, Y. Xue, Y. Zhang, Org. Lett. 19, 258-261 (2017). https://doi.org/10.1021/acs.orglett.6b03557
97. W. Li, C. Lee, S.H. Bang, J.Y. Ma, S. Kim, Y.S. Koh, S.H. Shim, J. Nat. Prod. 80, 205-209 (2017)
98. D. Zhang, H. Ge, J.H. Zou, X. Tao, R. Chen, J. Dai, Org. Lett. 16, 1410-1413 (2014)
99. K.L. Handore, P.D. Jadhav, B. Hazra, A. Basu, D.S. Reddy, A.C.S. Med, Chem. Lett. 6, 1117-1121 (2015). https://doi.org/10.1021/acsmedchemlett.5b00241
100. M.B. Gallo, M.J. Falso, F. Balem, D. Menezes, N. Rocha, R. Balachandran, T.S. Sturgeon, M.T. Pupo, B.W. Day, Planta Med. 80, 473-481 (2014). https://doi.org/10.1055/s-0034-1368301
101. J.R. Gubiani, M.L. Zeraik, C.M. Oliveira, V.F. Ximenes, C.R. Nogueira, L.M. Fonseca, D.H. Silva, V.S. Bolzani, A.R. Araujo, J. Nat. Prod. 77, 668-672 (2014). https://doi.org/10.1021/np400825s
102. J.W. Kim, H.G. Choi, J.H. Song, K.S. Kang, S.H. Shim, J. Antibiot. (2018). https://doi.org/10.1038/s41429-018-0131-2
103. U.J. Youn, T. Sripisut, E.J. Park, T.P. Kondratyuk, N. Fatima, C.J. Simmons, M.M. Wall, D. Sun, J.M. Pezzuto, L.C. Chang, Bioorg. Med. Chem. Lett. 25, 4719-4723 (2015)
104. K. Pudhom, T. Teerawatananond, J. Nat. Prod. 77, 1962-1966 (2014). https://doi.org/10.1021/np500068y
105. M. Zhao, L.Y. Yuan, D.L. Guo, Y. Ye, Z.M. Da-Wa, X.L. Wang, F.W. Ma, L. Chen, Y.C. Gu, L.S. Ding, Y. Zhou, Phytochemistry 148, 97-103 (2018)
106. W. Liu, S. Chen, J. Li, X. Yang, C. Yan, H. Liu, Nat. Prod. Res. 33, 354-359 (2019)
107. H.S. Chang, C.H. Lin, Y.S. Chen, H.C. Wang, H.Y. Chan, S.Y. Hsieh, H.C. Wu, M.J. Cheng, G.F. Yuan, S.Y. Lin, Y.J. Lin, I.S. Chen, Int. J. Mol. Sci. 17, E1512 (2016). https://doi.org/10.3390/ijms17091512
108. Y. Liu, M.H. Yang, X.B. Wang, T.X. Li, L.Y. Kong, Fitoterapia 109, 119-124 (2016)
109. C. Yan, W. Liu, J. Li, Y. Deng, S. Chen, H. Liu, RSC Adv. 8, 14823-14828 (2018)
110. J.L. Zhao, M. Zhang, J.M. Liu, Z. Tan, R.D. Chen, K.B. Xie, J.G. Dai, J. Asian Nat. Prod. Res. 19, 1028-1035 (2017). https://doi.org/10.1080/10286020.2017.1285908
111. A.D. Souza, E. Rodrigues-Filho, A.Q. Souza, J.Q. Pereira, A.K. Calgarotto, V. Maso, S. Marangoni, S.L. Da Silva, Toxicon 51, 240-250 (2008)
112. S. Mahapatra, D. Banerjee, Carbohydr. Polym. 90, 683-689 (2012)
113. M. Govindappa, H. Farheen, C.P. Chandrappa, Channabasava, R.V. Rai, V.B. Raghavendra, Adv. Nat. Sci 7, 035014 (2016). https://doi.org/10.1088/2043-6262/7/3/035014
114. W.C. Chi, K.L. Pang, W.L. Chen, G.J. Wang, T.H. Lee, Bot. Stud. 60, 4 (2019)
115. M.S. Lee, S.W. Wang, G.J. Wang, K.L. Pang, C.K. Lee, Y.H. Kuo, H.J. Cha, R.K. Lin, T.H. Lee, J. Nat. Prod. 79, 2983-2990 (2016). https://doi.org/10.1021/acs.jnatprod.6b00407
116. S. Chen, M. Ding, W. Liu, X. Huang, Z. Liu, Y. Lu, H. Liu, Z. She, Phytochemistry 146, 8-15 (2018). https://doi.org/10.1016/j.phytochem.2017.11.011
117. Y. Chen, Z. Liu, H. Liu, Y. Pan, J. Li, L. Liu, Z. She, Mar. Drugs 16, 54 (2018)
118. H. Chen, M. Huang, X. Li, L. Liu, B. Chen, J. Wang, Y. Lin, Fitoterapia 124, 103-107 (2018)
119. Z. Liu, P. Qiu, J. Li, G. Chen, Y. Chen, H. Liu, Z. She, Tetrahedron 74, 746-751 (2018)
120. Z. Liu, H. Liu, Y. Chen, Z. She, Nat. Prod. Res. 32, 2652-2656 (2018)
121. H. Cui, Y. Liu, J. Li, X. Huang, T. Yan, W. Cao, H. Liu, Y. Long, Z. She, J. Org. Chem. 83, 11804-11813 (2018). https://doi.org/10.1021/acs.joc.8b01738
122. H. Cui, Y. Liu, T. Li, Z. Zhang, M. Ding, Y. Long, Z. She, Fitoterapia 124, 177-181 (2018). https://doi.org/10.1016/j.fitote.2017.11.006
123. S. Chen, Z. Liu, H. Liu, Y. Long, D. Chen, Y. Lu, Z. She, Org. Biomol. Chem. 15, 6338-6341 (2017). https://doi.org/10.1039/c7ob01657c
124. C. Lee, S. Kim, W. Li, S. Bang, H. Lee, H.-J. Lee, E-Y. Noh, J-E. Jung-Eun Park, W.Y. Bang, S.H. Shim, J. Antibiot. 70, 737-742 (2017). https://doi.org/10.1038/ja.2017.39
125. M. Zhang, J.L. Zhao, J.M. Liu, R.D. Chen, K.B. Xie, D.W. Chen, K.P. Feng, D. Zhang, J.G. Dai, J. Asian Nat. Prod. Res. 19, 651-658 (2017). https://doi.org/10.1080/10286020.2016.1251908
126. Z.R. Ju, X. Qin, X.P. Lin, J.F. Wang, K. Kaliyaperumal, Y.Q. Tian, J. Liu, F. Liu, Z. Tu, S.H. Xu, Y. Liu, Nat. Prod. Res. 30, 192-198 (2016). https://doi.org/10.1080/14786419.2015.1050670
127. T.H. Quang, D.C. Kim, P. Van Kiem, C. Van Minh, N.X. Nhiem, B.H, Tai, P.H. Yen, N. Thi Thanh Ngan, H.J. Kim, H. Oh, J. Antibiot. 71, 826-830 (2018) https://doi.org/10.1038/s41429-018-0073-8.
128. H. Dou, Y. Song, X. Liu, W. Gong, E. Li, R. Tan, Y. Hou, Biol. Pharm. Bull. 34, 1864-1873 (2011)
129. T. Taechowisan, C. Lu, Y. Shen, S. Lumyong, Nat. Prod. Res. 21, 1104-1113 (2007)
130. T. Taechowisan, C. Lu, Y. Shen, S. Lumyong, Ann. Microbiol. 55, 63 (2005)
131. L. Rahman, Z.K. Shinwari, I. Iqrar, L. Rahman, F. Tanveer, Ann. Clin. Microbiol. Antimicrob. 16, 53 (2017). https://doi.org/10.1186/s12941-017-0228-7

[1]	Qiang Yin, Jianying Han, Guixiang Yang, Zhijun Song, Keke Zou, Kangjie Lv, Zexu Lin, Lei Ma, Miaomiao Liu, Yunjiang Feng, Ronald J. Quinn, Tom Hsiang, Lixin Zhang, Xueting Liu, Guoliang Zhu, Jingyu Zhang. New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus Bipolaris sorokiniana 11134 [J]. Natural Products and Bioprospecting, 2025, 15(3): 29-29.
[2]	Hongyan Wen, Sheng Li, Yu Zhang. Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities [J]. Natural Products and Bioprospecting, 2025, 15(3): 26-26.
[3]	Yuru Shi, Xiaoqian Zhang, Shengji Pei, Yuhua Wang. Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway [J]. Natural Products and Bioprospecting, 2024, 14(5): 36-36.
[4]	Shi-Yan Feng, Na Jiang, Jia-Ying Yang, Lin-Yao Yang, Jiang-Chao Du, Xuan-Qin Chen, Dan Liu, Rong-Tao Li, Jin-Dong Zhong. Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim [J]. Natural Products and Bioprospecting, 2024, 14(3): 26-26.
[5]	Orawan Jongsomjainuk, Jutatip Boonsombat, Sanit Thongnest, Hunsa Prawat, Paratchata Batsomboon, Sitthivut Charoensutthivarakul, Saroj Ruchisansakun, Kittipong Chainok, Jitnapa Sirirak, Chulabhorn Mahidol, Somsak Ruchirawat. Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis [J]. Natural Products and Bioprospecting, 2023, 13(6): 55-55.
[6]	Yang Yu, Yang Wang, Gui-Chun Wang, Cheng-Yong Tan, Yi Wang, Jin-Song Liu, Guo-Kai Wang. Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity [J]. Natural Products and Bioprospecting, 2023, 13(5): 31-31.
[7]	Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan, Gui-Hua Tang, Sheng Yin. New halimane and clerodane diterpenoids from Croton cnidophyllus [J]. Natural Products and Bioprospecting, 2023, 13(3): 21-21.
[8]	Cheng-Yong Tan, Bao-Bao Shi, Mei-Fen Bao, Xiang-Hai Cai. Anti-inflammatory maistemonine-class alkaloids of Stemona japonica [J]. Natural Products and Bioprospecting, 2023, 13(2): 8-8.
[9]	Sitian Zhang, Shuyuan Mo, Fengli Li, Yaxin Zhang, Jianping Wang, Zhengxi Hu, Yonghui Zhang. Drimane sesquiterpenoids from a wetland soil-derived fungus Aspergillus calidoustus TJ403-EL05 [J]. Natural Products and Bioprospecting, 2022, 12(4): 27-27.
[10]	Yue-Hu Wang. Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review [J]. Natural Products and Bioprospecting, 2021, 11(5): 465-487.
[11]	Marsya Yonna Nurrachma, Deamon Sakaraga, Ahmad Yogi Nugraha, Siti Irma Rahmawati, Asep Bayu, Linda Sukmarini, Akhirta Atikana, Anggia Prasetyoputri, Fauzia Izzati, Mega Ferdina Warsito, Masteria Yunovilsa Putra. Cembranoids of Soft Corals: Recent Updates and Their Biological Activities [J]. Natural Products and Bioprospecting, 2021, 11(3): 243-306.
[12]	Ning-Ning Wang, Chun-Yu Liu, Tian Wang, Yue-Lan Li, Ke Xu, Hong-Xiang Lou. Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity [J]. Natural Products and Bioprospecting, 2021, 11(1): 105-110.
[13]	Xiao-Li Cheng, Han-Xiang Li, Juan Chen, Ping Wu, Jing-Hua Xue, Zhong-Yu Zhou, Nia-He Xia, Xiao-Yi Wei. Bioactive Diarylheptanoids from Alpinia coriandriodora [J]. Natural Products and Bioprospecting, 2021, 11(1): 63-72.
[14]	Hongjuan Wang, Dezhi Yang, Li Li, Shiying Yang, Guanhua Du, Yang Lu. Anti-inflammatory Effects and Mechanisms of Rhein, an Anthraquinone Compound, and Its Applications in Treating Arthritis: A Review [J]. Natural Products and Bioprospecting, 2020, 10(6): 445-452.
[15]	Mohammad Sanad Abu-Darwish, Célia Cabral, Zulfigar Ali, Mei Wang, Shabana I. Khan, Melissa R. Jacob, Surendra K. Jain, Babu L. Tekwani, Fazila Zulfiqar, Ikhlas A. Khan, Hatem Taifour, Lígia Salgueiro, Thomas Efferth. Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities [J]. Natural Products and Bioprospecting, 2020, 10(5): 307-316.