Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina

doi:10.1007/s13659-018-0167-9

Natural Products and Bioprospecting ›› 2018, Vol. 8 ›› Issue (5): 347-353.DOI: 10.1007/s13659-018-0167-9

• ORIGINAL ARTICLES • Previous Articles Next Articles

Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina

Xiong-Wu Yang^1,3, Zhi Dai^2,3, Bei Wang^1,3, Ya-Ping Liu^1,4, Xu-Dong Zhao², Xiao-Dong Luo^1,4

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
4 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China

Received:2018-04-02 Revised:2018-05-07 Online:2018-09-19 Published:2018-10-24
Contact: Xu-Dong Zhao, Xiao-Dong Luo
Supported by:
The authors are grateful to the Natural Science Foundation of China (31770388, 81225024) and the "Ten Thousand Plan", a National High-level Talents Special Support Plan for partial financial support.

Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina

Xiong-Wu Yang^1,3, Zhi Dai^2,3, Bei Wang^1,3, Ya-Ping Liu^1,4, Xu-Dong Zhao², Xiao-Dong Luo^1,4

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
4 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China

通讯作者: Xu-Dong Zhao, Xiao-Dong Luo
基金资助:
The authors are grateful to the Natural Science Foundation of China (31770388, 81225024) and the "Ten Thousand Plan", a National High-level Talents Special Support Plan for partial financial support.

Abstract

Abstract: The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China. As a part of our continuous effort to search for bioactive molecules from the plant, the fruits of A. marina were investigated, which has led to one new triterpenoid saponin (1) and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data. The new triterpenoid saponin showed cytotoxicity against GSC-3# and GSC-18# with the IC₅₀ values were 12.21 and 5.53 μg/mL respectively, and most of the known compounds had significant antioxidant capacity with the IC₅₀ values ranging from 0.36 to 13.07 μg/mL.

Key words: Avicennia marina, Triterpenoid saponin, GSCs, DPPH

摘要： The fruits of Avicennia marina are widely used for both medicine and food in Guangxi of China. As a part of our continuous effort to search for bioactive molecules from the plant, the fruits of A. marina were investigated, which has led to one new triterpenoid saponin (1) and 29 known compounds been isolated and their structures were established by using spectroscopic methods and comparing with literature data. The new triterpenoid saponin showed cytotoxicity against GSC-3# and GSC-18# with the IC₅₀ values were 12.21 and 5.53 μg/mL respectively, and most of the known compounds had significant antioxidant capacity with the IC₅₀ values ranging from 0.36 to 13.07 μg/mL.

关键词: Avicennia marina, Triterpenoid saponin, GSCs, DPPH

Xiong-Wu Yang, Zhi Dai, Bei Wang, Ya-Ping Liu, Xu-Dong Zhao, Xiao-Dong Luo. Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina[J]. Natural Products and Bioprospecting, 2018, 8(5): 347-353.

Xiong-Wu Yang, Zhi Dai, Bei Wang, Ya-Ping Liu, Xu-Dong Zhao, Xiao-Dong Luo. Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina[J]. 应用天然产物, 2018, 8(5): 347-353.

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Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina

Antitumor Triterpenoid Saponin from the Fruits of Avicennia marina

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