Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

doi:10.1007/s13659-016-0086-6

Natural Products and Bioprospecting ›› 2016, Vol. 6 ›› Issue (1): 57-61.DOI: 10.1007/s13659-016-0086-6

• Original article • Previous Articles

Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

Bing-Dong Lin, Bin Zhou, Lei Dong, Yan Wu, Jian-Min Yue

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China

Received:2015-12-16 Revised:2016-01-04 Online:2018-02-08 Published:2016-02-24
Supported by:
Financial support from the National Natural Science Foundation (Grant No.U1302222;81321092) of the People's Republic of China is gratefully acknowledged.We thank Prof.S.-M.Huang of Hainan University for the identification of the plant material

Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

Bing-Dong Lin, Bin Zhou, Lei Dong, Yan Wu, Jian-Min Yue

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China

通讯作者: Jian-Min Yue,e-mail:jmyue@simm.ac.cn
基金资助:
Financial support from the National Natural Science Foundation (Grant No.U1302222;81321092) of the People's Republic of China is gratefully acknowledged.We thank Prof.S.-M.Huang of Hainan University for the identification of the plant material

Abstract

Abstract: Three new halimane-type diterpenoids formosins A-C (1-3), and three clerodane-type diterpenoids formosins D-F (4-6), were isolated from the twigs of Excoecaria formosana. Their structures were assigned on the basis of spectroscopic data analysis. Compounds 1 and 4 showed moderate anti-microbial activities against Bacillus subtilis (MIC=50 and 50 lg/mL, respectively). Compound 6 exhibited moderate anti-microbial activities against two strains of Helicobacter pylori (Hp-SS1 and ATCC 43504) with MIC values of 50 and 50 lg/mL, respectively.

Key words: Excoecaria formosana, Halimane-type, Clerodane-type, Diterpenoid, Anti-microbial

摘要： Three new halimane-type diterpenoids formosins A-C (1-3), and three clerodane-type diterpenoids formosins D-F (4-6), were isolated from the twigs of Excoecaria formosana. Their structures were assigned on the basis of spectroscopic data analysis. Compounds 1 and 4 showed moderate anti-microbial activities against Bacillus subtilis (MIC=50 and 50 lg/mL, respectively). Compound 6 exhibited moderate anti-microbial activities against two strains of Helicobacter pylori (Hp-SS1 and ATCC 43504) with MIC values of 50 and 50 lg/mL, respectively.

关键词: Excoecaria formosana, Halimane-type, Clerodane-type, Diterpenoid, Anti-microbial

Bing-Dong Lin, Bin Zhou, Lei Dong, Yan Wu, Jian-Min Yue. Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana[J]. Natural Products and Bioprospecting, 2016, 6(1): 57-61.

Bing-Dong Lin, Bin Zhou, Lei Dong, Yan Wu, Jian-Min Yue. Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana[J]. 应用天然产物, 2016, 6(1): 57-61.

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Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

Formosins A-F: Diterpenoids with Anti-microbial Activities from Excoecaria formosana

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