Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

doi:10.1007/s13659-015-0083-1

Natural Products and Bioprospecting ›› 2016, Vol. 6 ›› Issue (1): 31-39.DOI: 10.1007/s13659-015-0083-1

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Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

Qingxi Su¹, Peggy J. Brodie¹, Yixi Liu¹, James S. Miller², Naina M. Andrianjafy³, Rabodo Antsiferana⁴, Vincent E. Rasamison⁵, David G. I. Kingston¹

1. Department of Chemistry, Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg VA, 24061, USA;
2. Missouri Botanical Garden, P. O. Box 299, St. Louis, MO 63166-0299, USA;
3. Missouri Botanical Garden, B. P 3391, 101 Antananarivo, Madagascar;
4. Centre National d'Application des Recherches Pharmaceutiques, B. P 702, 101 Antananarivo, Madagascar

Received:2015-10-12 Revised:2015-12-19 Online:2018-02-08 Published:2016-02-24

Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

Qingxi Su¹, Peggy J. Brodie¹, Yixi Liu¹, James S. Miller², Naina M. Andrianjafy³, Rabodo Antsiferana⁴, Vincent E. Rasamison⁵, David G. I. Kingston¹

1. Department of Chemistry, Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg VA, 24061, USA;
2. Missouri Botanical Garden, P. O. Box 299, St. Louis, MO 63166-0299, USA;
3. Missouri Botanical Garden, B. P 3391, 101 Antananarivo, Madagascar;
4. Centre National d'Application des Recherches Pharmaceutiques, B. P 702, 101 Antananarivo, Madagascar

通讯作者: David G. I. Kingston,e-mail:dkingston@vt.edu

Abstract

Abstract: Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1-3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1-3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC₅₀ values of 2.8, 10.2 and 2.0 lM, respectively.

Key words: Antiproliferative activity, Triterpenoid saponins, Leptaulus citroides (Cardiopteridacea)

摘要： Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1-3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1-3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC₅₀ values of 2.8, 10.2 and 2.0 lM, respectively.

关键词: Antiproliferative activity, Triterpenoid saponins, Leptaulus citroides (Cardiopteridacea)

Qingxi Su, Peggy J. Brodie, Yixi Liu, James S. Miller, Naina M. Andrianjafy, Rabodo Antsiferana, Vincent E. Rasamison, David G. I. Kingston. Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest[J]. Natural Products and Bioprospecting, 2016, 6(1): 31-39.

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Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

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