Abstract: Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2, 2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H(1, 3, 4), 17-epi-rauvotetraphylline F(2) and 21-epi-rauvotetraphylline H(5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.

Key words: Rauvolfia tetraphylla, Monoterpenoid indole alkaloid, Rauvotetraphylline

摘要： Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2, 2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F-H(1, 3, 4), 17-epi-rauvotetraphylline F(2) and 21-epi-rauvotetraphylline H(5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.

关键词: Rauvolfia tetraphylla, Monoterpenoid indole alkaloid, Rauvotetraphylline