Integrative Biology Journals
Natural Products and Bioprospecting

Natural Products and Bioprospecting ›› 2014, Vol. 4 ›› Issue (2): 101-105.DOI: 10.1007/s13659-014-0010-x

• Original article • Previous Articles     Next Articles

Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus

Hamisi M. Malebo1, Stephan A. Jonker2, Reiner Waibel3, Mayunga H. H. Nkunya2   

  1. 1. Department of Traditional Medicine Research, National Institute for Medical Research, P. O. Box 9653, Dar es Salaam, Tanzania;
    2. Department of Chemistry, University of Dar es Salaam, P. O. Box 35061, Dar es Salaam, Tanzania;
    3. Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Erlangen, Schuhstrasse 19, 91052 Erlangen, Germany
  • Received:2014-02-17 Revised:2014-03-16 Online:2018-02-11 Published:2014-04-24
  • Supported by:
    The Norwegian Agency for International Development(NORAD) through the NORAD Chemistry Project is appreciated for supporting this work through a scholarship grant to H. M. M. The National Institute for Medical Research(NIMR), The Department of Chemistry at the University of Dar es Salaam in Tanzania and the Department of Pharmaceutical Chemistry in the Institute of Pharmacy at Erlangen University in Germany are thanked for supporting the research project.

Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus

Hamisi M. Malebo1, Stephan A. Jonker2, Reiner Waibel3, Mayunga H. H. Nkunya2   

  1. 1. Department of Traditional Medicine Research, National Institute for Medical Research, P. O. Box 9653, Dar es Salaam, Tanzania;
    2. Department of Chemistry, University of Dar es Salaam, P. O. Box 35061, Dar es Salaam, Tanzania;
    3. Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Erlangen, Schuhstrasse 19, 91052 Erlangen, Germany
  • 通讯作者: Hamisi M.Malebo,e-mail:Malebo@hotmail.com
  • 基金资助:
    The Norwegian Agency for International Development(NORAD) through the NORAD Chemistry Project is appreciated for supporting this work through a scholarship grant to H. M. M. The National Institute for Medical Research(NIMR), The Department of Chemistry at the University of Dar es Salaam in Tanzania and the Department of Pharmaceutical Chemistry in the Institute of Pharmacy at Erlangen University in Germany are thanked for supporting the research project.

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Abstract: New hexalobine type alkaloid, 5-(2", 3"-epoxy-3"-methylbutyl)-3-(3'-hydroxy-3'-methyl-1'-acetyloxy-but-2'-yl) indole(1) alongside the known hexalobines 3-(2', 3'-dihydroxy-3'-methylbutyl)-5-(3"-methylcrotonoyl) indole(2), 3, 5-hexalobine C(3) and 3, 5-hexalobine D(4) were isolated from fruits of Hexalobus monopetalus. Compounds 3 and 4 exhibited antifungal activity against Candida albicans.

Key words: Hexalobus monopetalus, Hexalobines, Indole alkaloids, Candida albicans

摘要： New hexalobine type alkaloid, 5-(2", 3"-epoxy-3"-methylbutyl)-3-(3'-hydroxy-3'-methyl-1'-acetyloxy-but-2'-yl) indole(1) alongside the known hexalobines 3-(2', 3'-dihydroxy-3'-methylbutyl)-5-(3"-methylcrotonoyl) indole(2), 3, 5-hexalobine C(3) and 3, 5-hexalobine D(4) were isolated from fruits of Hexalobus monopetalus. Compounds 3 and 4 exhibited antifungal activity against Candida albicans.

关键词: Hexalobus monopetalus, Hexalobines, Indole alkaloids, Candida albicans

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