Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

doi:10.1007/s13659-012-0018-z

Natural Products and Bioprospecting ›› 2012, Vol. 2 ›› Issue (2): 70-75.DOI: 10.1007/s13659-012-0018-z

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Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

Yan LI^a, Chang-Wei LI^a, Cheng-Bin CUI^a, Xing-Zhong LIU^b, Yong-Sheng CHE^,a

a Division of Natural Products Chemistry, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China;
b State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China

Received:2012-03-01 Revised:2012-03-08 Online:2018-02-11 Published:2012-04-24
Supported by:
We gratefully acknowledge financial support from the National Natural Science Foundation of China(30925039), the Beijing Natural Science Foundation(5111003), the Ministry of Science and Technology of China(2009CB522300 and 2010ZX09401-403), and the Chinese Academy of Sciences(KSCX2-EW-G-6).

Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

Yan LI^a, Chang-Wei LI^a, Cheng-Bin CUI^a, Xing-Zhong LIU^b, Yong-Sheng CHE^,a

a Division of Natural Products Chemistry, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China;
b State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China

通讯作者: Cheng-Bin CUI,E-mail:cuicb@126.com;Yong-Sheng CHE,E-mail:cheys@im.ac.cn
基金资助:
We gratefully acknowledge financial support from the National Natural Science Foundation of China(30925039), the Beijing Natural Science Foundation(5111003), the Ministry of Science and Technology of China(2009CB522300 and 2010ZX09401-403), and the Chinese Academy of Sciences(KSCX2-EW-G-6).

Abstract

Abstract: Three new caryophyllene sesquiterpenoids, cytosporinols A-C(1-3), have been isolated from solid cultures of Cytospora sp. The structures of 1-3 were elucidated primarily by NMR spectroscopy, and 3 was further confirmed by X-ray crystallography. The absolute configurations of the C-11 secondary alcohol in 1 and the 6, 8-diol moiety in 3 were deduced using the modified Mosher and Snatzke's method, respectively. Compounds 2 and 3 showed moderate cytotoxicity against HeLa cells.

Key words: caryophyllene sesquiterpenoid, cytosporinol, Cytospora sp.

摘要： Three new caryophyllene sesquiterpenoids, cytosporinols A-C(1-3), have been isolated from solid cultures of Cytospora sp. The structures of 1-3 were elucidated primarily by NMR spectroscopy, and 3 was further confirmed by X-ray crystallography. The absolute configurations of the C-11 secondary alcohol in 1 and the 6, 8-diol moiety in 3 were deduced using the modified Mosher and Snatzke's method, respectively. Compounds 2 and 3 showed moderate cytotoxicity against HeLa cells.

关键词: caryophyllene sesquiterpenoid, cytosporinol, Cytospora sp.

Yan LI, Chang-Wei LI, Cheng-Bin CUI, Xing-Zhong LIU, Yong-Sheng CHE. Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.[J]. Natural Products and Bioprospecting, 2012, 2(2): 70-75.

Yan LI, Chang-Wei LI, Cheng-Bin CUI, Xing-Zhong LIU, Yong-Sheng CHE. Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.[J]. 应用天然产物, 2012, 2(2): 70-75.

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Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

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