α-C(sp3)-H Arylation of Cyclic Carbonyl Compounds

doi:10.1007/s13659-021-00312-1

Natural Products and Bioprospecting ›› 2021, Vol. 11 ›› Issue (4): 379-404.DOI: 10.1007/s13659-021-00312-1

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α-C(sp³)-H Arylation of Cyclic Carbonyl Compounds

Mei Wang¹, Wei Wang¹, Dashan Li¹, Wen-Jing Wang¹, Rui Zhan², Li-Dong Shao¹

1 Yunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650050, China;
2 School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China

Received:2021-04-07 Accepted:2021-05-24 Online:2021-07-30 Published:2021-08-24
Contact: Rui Zhan, Li-Dong Shao
Supported by:
We gratefully acknowledge financial support from the National Science of Foundation of China (81960631), the Yunnan Fundamental Research Project (202001AS070038), the Top Young Talent of Ten Thousand Talents Program of Yunnan Province (R. Zhan and L.-D Shao), and the Start-up Fund of Yunnan University of Chinese Medicine (2019YZG03).

α-C(sp³)-H Arylation of Cyclic Carbonyl Compounds

Mei Wang¹, Wei Wang¹, Dashan Li¹, Wen-Jing Wang¹, Rui Zhan², Li-Dong Shao¹

1 Yunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650050, China;
2 School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China

通讯作者: Rui Zhan, Li-Dong Shao
基金资助:
We gratefully acknowledge financial support from the National Science of Foundation of China (81960631), the Yunnan Fundamental Research Project (202001AS070038), the Top Young Talent of Ten Thousand Talents Program of Yunnan Province (R. Zhan and L.-D Shao), and the Start-up Fund of Yunnan University of Chinese Medicine (2019YZG03).

Abstract

Abstract: α-C(sp³)-H arylation is an important type of C-H functionalization. Various biologically significant natural products, chemical intermediates, and drugs have been effectively prepared via C-H functionalization. Cyclic carbonyl compounds comprise of cyclic ketones, enones, lactones, and lactams. The α-C(sp³)-H arylation of these compounds have been exhibited high efficiency in forming C(sp³)-C(sp²) bonds, played a crucial role in organic synthesis, and attracted majority of interests from organic and medicinal communities. This review focused on the most significant advances including methods, mechanism, and applications in total synthesis of natural products in the field of α-C(sp³)-H arylations of cyclic carbonyl compounds in recent years.

Key words: C-H functionalization, α-C(sp³)-H arylation, Cyclic carbonyl compounds

摘要： α-C(sp³)-H arylation is an important type of C-H functionalization. Various biologically significant natural products, chemical intermediates, and drugs have been effectively prepared via C-H functionalization. Cyclic carbonyl compounds comprise of cyclic ketones, enones, lactones, and lactams. The α-C(sp³)-H arylation of these compounds have been exhibited high efficiency in forming C(sp³)-C(sp²) bonds, played a crucial role in organic synthesis, and attracted majority of interests from organic and medicinal communities. This review focused on the most significant advances including methods, mechanism, and applications in total synthesis of natural products in the field of α-C(sp³)-H arylations of cyclic carbonyl compounds in recent years.

关键词: C-H functionalization, α-C(sp³)-H arylation, Cyclic carbonyl compounds

Mei Wang, Wei Wang, Dashan Li, Wen-Jing Wang, Rui Zhan, Li-Dong Shao. α-C(sp³)-H Arylation of Cyclic Carbonyl Compounds[J]. Natural Products and Bioprospecting, 2021, 11(4): 379-404.

Mei Wang, Wei Wang, Dashan Li, Wen-Jing Wang, Rui Zhan, Li-Dong Shao. α-C(sp³)-H Arylation of Cyclic Carbonyl Compounds[J]. 应用天然产物, 2021, 11(4): 379-404.

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α-C(sp³)-H Arylation of Cyclic Carbonyl Compounds

α-C(sp³)-H Arylation of Cyclic Carbonyl Compounds

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