Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile

doi:10.1007/s13659-020-00245-1

Natural Products and Bioprospecting ›› 2020, Vol. 10 ›› Issue (3): 163-170.DOI: 10.1007/s13659-020-00245-1

• ORIGINAL ARTICLES • Previous Articles

Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile

Hui-Min Zhou^1,2, Yan-Song Ye^1,2, Na-Na Jiang^1,2, Rong-Fang Mu^1,2, Qian Wang^1,2, Jing Hu¹, Xia Liu³, Wan-Ying Qin^1,2, Gang Xu^1,2, Wen-Yong Xiong^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Department of Pharmacy, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China

Received:2020-04-03 Revised:2020-05-16 Online:2020-06-02 Published:2020-06-24
Contact: Gang Xu, Wen-Yong Xiong
Supported by:
The work was supported by Yunnan Provincial Science and Technology Department, China (2017FA044), and Chongqing Municipal Natural Science Foundation (cstc2018jcyjAX0388).

Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile

Hui-Min Zhou^1,2, Yan-Song Ye^1,2, Na-Na Jiang^1,2, Rong-Fang Mu^1,2, Qian Wang^1,2, Jing Hu¹, Xia Liu³, Wan-Ying Qin^1,2, Gang Xu^1,2, Wen-Yong Xiong^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Department of Pharmacy, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China

通讯作者: Gang Xu, Wen-Yong Xiong
基金资助:
The work was supported by Yunnan Provincial Science and Technology Department, China (2017FA044), and Chongqing Municipal Natural Science Foundation (cstc2018jcyjAX0388).

Abstract

Abstract: Adamantane polycyclic polyprenylated acylphloroglucinols (PPAPs) with caged architecture, a special class of hybrid natural products, is specifically rich in the plant family Guttiferae, especially Hypericum or Garcinia genus. Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile. Here we have chosen, screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation. Particularly, the compound, hypersampsone P, blunted the adipocyte differentiation dose-dependently. Moreover, hypersampsone P down-regulated the expressions of several key regulators for adipogenesis, including PPARγ and FABP4. The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.

Key words: Adipogenesis, LKB1, AMPK, Hypericum subsessile, Hypersampsone P

摘要： Adamantane polycyclic polyprenylated acylphloroglucinols (PPAPs) with caged architecture, a special class of hybrid natural products, is specifically rich in the plant family Guttiferae, especially Hypericum or Garcinia genus. Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile. Here we have chosen, screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation. Particularly, the compound, hypersampsone P, blunted the adipocyte differentiation dose-dependently. Moreover, hypersampsone P down-regulated the expressions of several key regulators for adipogenesis, including PPARγ and FABP4. The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.

关键词: Adipogenesis, LKB1, AMPK, Hypericum subsessile, Hypersampsone P

Hui-Min Zhou, Yan-Song Ye, Na-Na Jiang, Rong-Fang Mu, Qian Wang, Jing Hu, Xia Liu, Wan-Ying Qin, Gang Xu, Wen-Yong Xiong. Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile[J]. Natural Products and Bioprospecting, 2020, 10(3): 163-170.

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Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile

Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile

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