Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata

doi:10.1007/s13659-019-0213-2

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (4): 297-302.DOI: 10.1007/s13659-019-0213-2

• ORIGINAL ARTICLES • Previous Articles Next Articles

Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata

Si-Yue Chen^1,2, Chang-An Geng¹, Yun-Bao Ma¹, Ji-Jun Chen^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China

Received:2019-04-23 Revised:2019-05-22 Online:2019-08-09 Published:2019-08-24
Contact: Ji-Jun Chen
Supported by:
This work was supported by the Program of Yunling Scholar, the Youth Innovation Promotion Association, CAS (2013252), and the Applied Basic Research Programs of Yunnan Province (2017FB137).

Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata

Si-Yue Chen^1,2, Chang-An Geng¹, Yun-Bao Ma¹, Ji-Jun Chen^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China

通讯作者: Ji-Jun Chen
基金资助:
This work was supported by the Program of Yunling Scholar, the Youth Innovation Promotion Association, CAS (2013252), and the Applied Basic Research Programs of Yunnan Province (2017FB137).

Abstract

Abstract: Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (1-3) were isolated from the EtOAc extract of G. elata. Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound 1 showed agonistic effects on MT₁ and MT₂ receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC₅₀ value of 76.24 μM on MT₂ receptor.

Key words: Gastrodia elata, Gastropolybenzylols, Melatonin receptors

摘要： Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (1-3) were isolated from the EtOAc extract of G. elata. Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound 1 showed agonistic effects on MT₁ and MT₂ receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC₅₀ value of 76.24 μM on MT₂ receptor.

关键词: Gastrodia elata, Gastropolybenzylols, Melatonin receptors

Si-Yue Chen, Chang-An Geng, Yun-Bao Ma, Ji-Jun Chen. Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata[J]. Natural Products and Bioprospecting, 2019, 9(4): 297-302.

Si-Yue Chen, Chang-An Geng, Yun-Bao Ma, Ji-Jun Chen. Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata[J]. 应用天然产物, 2019, 9(4): 297-302.

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Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata

Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata

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