Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

doi:10.1007/s13659-019-00225-0

Natural Products and Bioprospecting ›› 2019, Vol. 9 ›› Issue (6): 411-418.DOI: 10.1007/s13659-019-00225-0

• ORIGINAL ARTICLES • Previous Articles Next Articles

Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

G. R. Nalin Rathnayake¹, N. Savitri Kumar¹, Lalith Jayasinghe¹, Hiroshi Araya², Yoshinori Fujimoto^1,2

1 National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka;
2 School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan

Received:2019-07-01 Revised:2019-11-03 Online:2019-12-11 Published:2019-12-24
Contact: Lalith Jayasinghe
Supported by:
Financial support from the National Research Council (Research Grant NRC 12-032) is gratefully acknowledged.

Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

G. R. Nalin Rathnayake¹, N. Savitri Kumar¹, Lalith Jayasinghe¹, Hiroshi Araya², Yoshinori Fujimoto^1,2

1 National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka;
2 School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan

通讯作者: Lalith Jayasinghe
基金资助:
Financial support from the National Research Council (Research Grant NRC 12-032) is gratefully acknowledged.

Abstract

Abstract: An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1-5, 7 and 8 from P. microspora are reported here for the first time.

Key words: Pestalotiopsis microspora, Manilkara zapota, Endophyte, Pitholide E, Pestalotin

摘要： An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1-5, 7 and 8 from P. microspora are reported here for the first time.

关键词: Pestalotiopsis microspora, Manilkara zapota, Endophyte, Pitholide E, Pestalotin

G. R. Nalin Rathnayake, N. Savitri Kumar, Lalith Jayasinghe, Hiroshi Araya, Yoshinori Fujimoto. Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora[J]. Natural Products and Bioprospecting, 2019, 9(6): 411-418.

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Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

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