Residual Dipolar Couplings in Structure Determination of Natural Products

doi:10.1007/s13659-018-0174-x

Abstract

Abstract: The determination of natural products stereochemistry remains a formidable task. Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for determination of the stereochemistry of organic molecule in solution. This review will provide a short introduction on RDCs-based methodology for the structural elucidation of natural products. Special attention is given to the current availability of alignment media in organic solvents. The applications of RDCs for structural analysis of some examples of natural products were discussed and summarized.

Key words: NMR spectroscopy, Residual dipolar couplings, Alignment media, Structural elucidation, Natural products

摘要： The determination of natural products stereochemistry remains a formidable task. Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for determination of the stereochemistry of organic molecule in solution. This review will provide a short introduction on RDCs-based methodology for the structural elucidation of natural products. Special attention is given to the current availability of alignment media in organic solvents. The applications of RDCs for structural analysis of some examples of natural products were discussed and summarized.

关键词: NMR spectroscopy, Residual dipolar couplings, Alignment media, Structural elucidation, Natural products

Gao-Wei Li, Han Liu, Feng Qiu, Xiao-Juan Wang, Xin-Xiang Lei. Residual Dipolar Couplings in Structure Determination of Natural Products[J]. Natural Products and Bioprospecting, 2018, 8(4): 279-295.

Gao-Wei Li, Han Liu, Feng Qiu, Xiao-Juan Wang, Xin-Xiang Lei. Residual Dipolar Couplings in Structure Determination of Natural Products[J]. 应用天然产物, 2018, 8(4): 279-295.

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