Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens

doi:10.1007/s13659-014-0007-5

Natural Products and Bioprospecting ›› 2014, Vol. 4 ›› Issue (2): 73-79.DOI: 10.1007/s13659-014-0007-5

• Original article • Previous Articles Next Articles

Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens

Jing-Jing Zhang^1,2, Xing-Wei Yang^1,2, Jun-Zeng Ma¹, Xia Liu¹, Li-Xin Yang¹, Sheng-Chao Yang³, Gang Xu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Received:2014-01-13 Revised:2014-02-24 Online:2018-02-11 Published:2014-04-24
Supported by:
The work was financially supported by the foundations from NSFC(20972167), the Young Academic Leader Raising Foundation of Yunnan Province(No. 2009CI073), and the foundation from CAS to Dr G. Xu.

Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens

Jing-Jing Zhang^1,2, Xing-Wei Yang^1,2, Jun-Zeng Ma¹, Xia Liu¹, Li-Xin Yang¹, Sheng-Chao Yang³, Gang Xu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

通讯作者: Sheng-Chao Yang,e-mail:shengchaoyang@163.com;Gang Xu,e-mail:xugang008@mail.kib.ac.cn
基金资助:
The work was financially supported by the foundations from NSFC(20972167), the Young Academic Leader Raising Foundation of Yunnan Province(No. 2009CI073), and the foundation from CAS to Dr G. Xu.

Abstract

Abstract: Four new polycyclic polyprenylated acylphloroglucinol type metabolites, hypercohones D-G(1-4), along with four known analogues(5-8), were isolated from the aerial parts of Hypericum cohaerens. The structures of these isolates were elucidated by extensive spectroscopic methods. The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

Key words: Guttiferae, Hypericum cohaerens, Acylphloroglucinol, Hypercohones D-G

摘要： Four new polycyclic polyprenylated acylphloroglucinol type metabolites, hypercohones D-G(1-4), along with four known analogues(5-8), were isolated from the aerial parts of Hypericum cohaerens. The structures of these isolates were elucidated by extensive spectroscopic methods. The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

关键词: Guttiferae, Hypericum cohaerens, Acylphloroglucinol, Hypercohones D–G

Jing-Jing Zhang, Xing-Wei Yang, Jun-Zeng Ma, Xia Liu, Li-Xin Yang, Sheng-Chao Yang, Gang Xu. Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens[J]. Natural Products and Bioprospecting, 2014, 4(2): 73-79.

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Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens

Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens

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